epidermal barrier
Sphingolipids are required for mammalian epidermal barrier function Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation
... the epidermal permeability ...in epidermal barrier function lead to a rapid increase in cholesterol and fatty acid synthesis which parallels the early stages of the repair ...the barrier, the ...
9
Current evidence of epidermal barrier dysfunction and thymic stromal lymphopoietin in the atopic march
... compromised barrier function is associated with skin inflammation and ...previously, epidermal barrier dysfunction could be a result of multiple abnormalities [12, 13]; therefore, it is not ...
7
Akt dependent Pp2a activity is required for epidermal barrier formation during late embryonic development
... developmental barrier acquisition, rat epidermal keratinocyte organotypic cultures were grown on de-epidermized dermis at the air-liquid interface for 5 and 10 days (Baden and Kubilus, 1983; Marjukka et ...
9
Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat Acceleration by estrogen and delay by testosterone
... from barrier lipids, both secretory sys- tems deliver lipid to their respective extracellular domains (1–3, ...the epidermal and lung lamellar secretory systems exhibit striking similarities in their ...
10
Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development
... development, epidermal stem cells undergo a particular differentiation program and generate a stratified epidermis ...The epidermal stem cells in the basal layer maintain a balance between quiescence and ...
20
The effect of Psoroptes ovis infestation on ovine epidermal barrier function
... the epidermal barrier. Integrity of the skin barrier is critical in preventing exces- sive transepidermal water loss (TEWL) and in skin defence by reducing penetration of exogenous molecules ...
11
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
... on epidermal barrier dysfunction as a causative ...skin’s barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid bar- rier), and the ...
9
Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response
... significant epidermal changes, including keratinocyte hyperproliferation, incomplete differentiation, and impaired ...impaired epidermal barrier can promote an inflammatory ...in epidermal ...
12
Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses☆
... the epidermal barrier ...the epidermal barrier ...impaired epidermal barrier, including numerous skin diseases (atopic dermatitis, psoriasis, ichthyo- ses), as well as aged skin ...
7
Epidermal barrier formation and recovery in skin disorders
... semipermeable epidermal barrier prevents both the escape of moisture and the entry of infectious or toxic ...congenital barrier defects underscore the skin’s essential role in a terrestrial ...
10
Surface Electrical Capacitance as a Noninvasive Beside Measure of Epidermal Barrier Maturation in the Newborn Infant
... These findings indicate rapid maturation of epidermal barrier function during the first 5 postnatal days in this group of very premature infants (n = 4). (I)[r] ...
7
Large scale identification of human genes implicated in epidermal barrier function
... mis barrier function (for example, KRT1, DMKN, LEP7, FLG, KRT2A, SPRR2E, CASP14, CDSN, hKRP, SBSN) and, inter- estingly, new candidates for this function (TSPAN5, DUOX2, TMEM14C, SERPINA12, SLC22A5, FLG2, ...
23
A nervous breakdown in the skin: stress and the epidermal barrier
... protective barrier function, psychological stress, and HPA axis activity is limited because of the fundamental dif- ferences in skin physiology and pathology between rodents and ...of epidermal and adnexal ...
5
Hypercholesterolemia in young adult APOE−/− mice alters epidermal lipid composition and impairs barrier function
... The epidermal FFA composition of the APOE −/− mice greatly dif- fered from that of the WT controls. Therefore, the expression of genes involved in lipid synthesis and uptake from circulation was assessed by ...
9
Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier
... of barrier function or epider- mal ...accelerated epidermal de- velopment, resulting in mature lamellar membranes, a mul- tilayered SC, and a competent barrier after 2 d of incuba- ...accelerated ...
9
A GRHL3 regulated repair pathway suppresses immune mediated epidermal hyperplasia
... whether epidermal factors play a primary role in the development of these ...during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult ...
15
Role of Integrin-linked kinase in epidermal integrity and barrier function
... Tight junctions function as gates in the epidermis, to modulate diffusion of small soluble molecules. Tight junctions contain occludin, claudin and junctional adhesion molecules called JAMs, which are connected to ...
235
The aged epidermal permeability barrier Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model
... contact dermatitis, and often severe xerosis, suggesting compromise of the aged epidermal barrier. To delineate the functional, structural, and lipid biochemical basis of epidermal aging, we compared ...
11
Current Perspectives Series: Filaggrin in Atopic Dermatitis
... Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.. Weidinger S, Illig T, Baurecht H, Irvine AD, Rodriguez[r] ...
17
mTORC1 loss impairs epidermal adhesion via TGF β/Rho kinase activation
... whether epidermal thinning in Rheb-cKO mice might be due to decreased net ...the epidermal barrier defect, we examined expression of Ki-67 in the basal pro- liferative epidermal compartment at ...
18