Epidermal Differentiation
DEFECTIVE KERNEL 1 promotes and maintains plant epidermal differentiation
... is epidermal cell separation, suggesting that DEK1 might regulate this zone of cell-cell contact (Ahn et ...between epidermal cells is perturbed, further supporting this ...thus epidermal ...
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p63 and Brg1 control developmentally regulated higher order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells
... and differentiation of multipotent stem cells into specialised cell types remains poorly ...the epidermal differentiation complex (EDC), a keratinocyte lineage-specific gene locus on mouse chromosome ...
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Rapid and widespread suppression of self renewal by microRNA 203 during epidermal differentiation
... miR-203 is thought to have an important role during epidermal differentiation (Yi et al., 2008). However, the precise dynamics of the upregulation of miR-203 remain unclear. We set out to determine the ...
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Evidence for local control of gene expression in the epidermal differentiation complex
... Figure 5. Differential epidermal differentiation complex (EDC) gene expression in various cell types, and in normal vs. psoriatic skin. Each lane was loaded with 40 mg total RNA. Replicate blots (three in ...
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BMP4 dependent expression of Xenopus Grainyhead like 1 is essential for epidermal differentiation
... in epidermal differentiation. (A) Defective epidermal structures observed in tadpoles (arrowheads) in ∆ 227XGrhl1-injected ( ∆ 227) but not wild-type (wt) ...normal epidermal structure with ...
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Desmoglein 1/Erbin interaction suppresses ERK activation to support epidermal differentiation
... These data led us to investigate the DSG1 C terminus as a poten- tial scaffold for intracellular signaling events. A subset of patients with striate palmoplantar keratoderma (SPPK) are DSG1 deficient, with keratinization ...
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Thrombomodulin expression by human keratinocytes Induction of cofactor activity during epidermal differentiation
... Stimulation of keratinocyte differentiation with 1.4 mM calcium chloride for 48 h produced 3.5-, 3.2-, and 5.6-fold increases in thrombomodulin cofactor activity, antigen, and mRNA, respectively. These ...
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Epidermal differentiation: trichomes in Arabidopsis as a model system
... A group of eight genes, that are collectively referred to as "distorted" mutants share a common trichome phenotype: tri- chomes develop fairly normal until the branches have been initi- ated and with the onset of ...
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Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds
... epidermal migration and proliferation in a rabbit ear model of excisional wound repair. In this model, recombinant human NDF-alpha 2 (rhNDF-alpha 2), applied once at the time of wounding, induced a highly ...
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Transcription Factor Sp2 Regulates Growth, Differentiation, and Tumorigenesis of Epidermal Stem Cells.
... arrested differentiation of the interfollicular ...for epidermal differentiation, paraffin-embedded whole skin sections were prepared from Sp2-A homozygotes and wild- type littermates on successive ...
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MALDI MSI for the analysis of a 3D tissue engineered psoriatic skin model
... the epidermal differentiation of Labskin, a living skin equivalent (LSE), successfully modeled psoriasis in ...of epidermal differentiation between the untreated and IL-22 treated psoriatic ...
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Filaggrin in the frontline: role in skin barrier function and disease
... Eczema is a very common, highly heritable and distressing inflammatory skin disease that affects around 20% of children in the developed world. Eczema is associated with asthma in around 30% of cases, as well as with a ...
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MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model
... the epidermal differentiation of Labskin, a living skin equivalent (LSE), successfully modeled psoriasis in ...of epidermal differentiation between the untreated and IL-22 treated psoriatic ...
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Phytosphingosine Stimulates the Differentiation of Human Keratinocytes and Inhibits TPA-Induced Inflammatory Epidermal Hyperplasia in Hairless Mouse Skin
... regulating epidermal cell growth, terminal differentiation, and inflammatory response, we examined the effect of PS on normal human epidermal keratinocytes (NHEKs) and mouse ...controls. ...
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The co repressor hairless has a role in epithelial cell differentiation in the skin
... HR action as a co-repressor fits well with the role of transcriptional regulatory proteins in mediating hair and skin development and function. As a co-repressor, HR does not directly regulate transcriptional activity ...
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Epithelial barrier repair and prevention of allergy
... keratinocyte differentiation process is under tight regulation. During epidermal differentiation, keratinocytes sequentially switch gene expression programs, resulting in terminal ...
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Commensal microbiota modulate gene expression in the skin
... “keratinocyte differentiation” was significantly enriched in DEGs (FDR corrected p value ...the epidermal differentiation complex (EDC), a cluster of genes found on murine chromosome 3 encoding ...
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Pathophysiology of osteoarthritis: canonical NF κB/IKKβ dependent and kinase independent effects of IKKα in cartilage degradation and chondrocyte differentiation
... failed epidermal differentiation, which disrupted normal epidermal – mesodermal ...terminal epidermal cell ...chondrocyte differentiation towards ...
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The role of the skin barrier in modulating the effects of common skin microbial species on the inflammation, differentiation and proliferation status of epidermal keratinocytes
... display limited proinflammatory and cytotoxic effects in some replicates when tested at high concentrations. However, it is unlikely that concentrations of S. aureus would reach these values on top of human skin in vivo ...
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Toxic Epidermal Necrolysis in Childhood: Differentiation from Staphylococcal Scalded Skin Syndrome
... Melish ME, Glasgow LA: Staphylococcal scalded skin syn- drome: The expanded clinical syndrome. Wiley BB, Ailman S, Rogolsky M: Staphylococcal scalded[r] ...
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