error prone DNA repair
18 F-fluorothymidine uptake in follicular lymphoma and error-prone DNA repair
... of DNA replication and repair markers in FL suggests that the disproportional increase of 18 F-FLT uptake might be due to error-prone DNA repair, responsible for SHM/CSR in FL ...
7
Selection-Enhanced Mutagenesis of lac Genes Is Due to Their Coamplification with dinB Encoding an Error-Prone DNA Polymerase
... The behavior of the Cairns–Foster system has been widely interpreted as evidence that all cells possess evolved mecha- nisms that sense growth limitation and respond by increasing their general mutation rate (Torkelson ...
13
a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects.
... For srs2 null diploids, also affected in the error-prone repair pathway, we show that their G I U V sensitivity, likely due to lethal recombination events, is partly su[r] ...
10
Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer
... of DNA double-stand breaks ...erroneous repair of DSBs can lead to chromosomal rearrangements and loss of heterozygosity, which in turn can also cause cancer and cell ...the repair of DSBs is crucial ...
8
Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma
... inducing DNA damage. A cell’s DNA damage response (DDR) involves a complex interplay of pathways designed to recognise and repair lesions occurring during normal cellular processes and those induced ...
13
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
... induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their ...either error-prone repair pathways that induce random ...
26
Studies on protein:protein interactions in mammalian DNA base-excision repair
... highly error prone as a genetic template - its structure is exposed to hydrolysis due to the presence of the 2 -OH group of ...stable DNA occurred via reduction of the 2 -OH ribose, making DNA ...
210
The Saccharomyces cerevisiae RAD6 Group Is Composed of an Error-Prone and Two Error-Free Postreplication Repair Pathways
... of DNA damage. Although RAD30 functions in an error-free manner, the rad30 mutation is not synergistic with rev mutations (McDonald et ...UmuC DNA poly- merase superfamily proteins (Nelson et ...
9
A Role for DNA Mismatch Repair Protein Msh2 in Error-Prone Double-Strand-Break Repair in Mammalian Chromosomes
... nascent DNA strand is joined via NHEJ to a DNA terminus the loss of a functional MMR machinery, such as is from the other side of the ...the repair process. In this figure, DNA segments ...
10
Role of Saccharomyces cerevisiae Chromatin Assembly Factor-I in Repair of Ultraviolet Radiation Damage in Vivo
... onto DNA templates after ...yeast repair gene mutations to show that deletion of the CAC1 gene increases the UV sensitivity of cells mutant in genes from each of the known DNA repair epistasis ...
13
Size and shape analysis of error prone shape data
... measurement error among all estima- tors involved in matching ...measurement error models formulated in Section 2, followed by estimating equations based on these ...using error-contaminated data (Y, ...
10
A comparative evaluation of hybrid error correction methods for error prone long reads
... high error rate is inherent to the low signal-to-noise ratio in single-molecule sequencing technologies, it will be hard to achieve the accuracy of SGS in the near fu- ture ...Thus, error correction prior ...
17
Clinical study to compare the short term outcomes in six months follow up period with Respect to open mesh and non mesh repair based on randomization
... Open hernia is begun with a straight or curvilinear incision approximately two finger breadths above inguinal ligament. Dissection is carried through the subcutaneous tissues, and the external oblique fascia is incised. ...
10
Human Papillomaviruses Preferentially Recruit DNA Repair Factors to Viral Genomes for Rapid Repair and Amplification
... (2). DNA lysates were harvested from undifferentiated and differentiated cells and examined by Southern blot analysis following ...smaller DNA fragments, DNAs were first digested with XhoI, which lacks ...
18
The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway.
... SRS2 suppresses the DNA repair but not the UV mutagenesis and sporulation defects of the rud6A mutation: rad6 mutants are defective in DNA repair, induced mutagenesis a[r] ...
15
The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia
... incomplete DNA repair mechan- isms are responsible for the formation of chromosomal ...the DNA repair pathway as a form of treatment is relatively new, and although it has been shown to be ...
9
Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
... mismatch repair [MMR] pathway predicted to be required to repair damage to single bases arising from errors in DNA replication) resulted in increased proliferation in a lung assay of cryptococcosis ...
18
Advances in using PARP inhibitors to treat cancer
... of DNA integrity as part of the base excision pathway of DNA ...to repair DNA damage may have antitumor activity in itself, as well as enhance the antineoplastic potential of cytotoxic ...
5
Retrovirus recombination depends on the length of sequence identity and is not error prone.
... The rate of recombination between two partially identical RNA molecules never reached that of recombination between essentially homologous molecules even when there was extensive sequenc[r] ...
6
Exploring the evolvability of resistance determinants in bacteria : a dissertation submitted in partial fulfilment for the degree of Doctor of Philosophy in Biochemistry at Massey University, Albany, New Zealand
... 4.1 INTRODUCTION 4.1.1 DIRECTED EVOLUTION ON YEJG 4.1.2 YEJG 4.2 RESULTS 4.2.1 YEJG ERROR-PRONE PCR LIBRARY 4.2.2 SELECTING YEJG ‘WINNERS’ TOBRAMYCIN 4.2.3 DNA SEQUENCING OF YEJG MUTANTS[r] ...
17