Family-based association analysis
Family based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
... genome-wide association study using SAGE (the Study of Addiction: Genetics and Environment) and COGA (Collaborative Study on the Genetics of Alcoholism) found five SNPs within the KIAA0040 gene significantly ...
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A Powerful Nonparametric Statistical Framework for Family-Based Association Analyses
... For family-based association studies, the most widely adopted statistical method is the transmission disequilib- rium test (TDT) (Spielman et ...for family triads with dichotomous ...a ...
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Recommendations for using standardised phenotypes in genetic association studies
... Genetic association studies of complex traits often rely on standardised quantitative phenotypes, such as percen- tage of predicted forced expiratory volume and body mass index to measure an underlying trait of ...
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A comparison of whole genome sequencing with exome sequencing for family based association studies
... decreases, association studies based on whole genome sequencing are now becoming ...for family-based association analysis using data from Genetic Analysis Workshop ...
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Genetic association tests: a method for the joint analysis of family and case-control data
... genome-wide association studies and complex model- ling, the need for large sample sizes to detect small effects and to allow for the estimation of many parameters within a model continues to ...of ...
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Application of family based tests of association for rare variants to pathways
... of association. Historically, gene-based tests of asso- ciation aggregated a small number of SNVs within a gene into a single test statistic, whereas pathway-based tests operated in 2 stages ...
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Implicit Hypotheses Are Hidden Power Droppers in Family Based Association Studies of Secondary Outcomes
... (genome-wide) association studies at the ...netic association study designs are derived from usual case-control retrospective epidemiological studies ...and analysis of families. Such ...
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Accounting for relatedness in family based association studies: application to Genetic Analysis Workshop 18 data
... In the last few years, a bewildering variety of methods/software packages that use linear mixed models to account for sample relatedness on the basis of genome-wide genomic information have been proposed. We compared ...
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Statistical Methods for Family-Based Association Studies for Complex Human Diseases: Single-Locus and Haplotype Methods
... haplotype analysis to reduce the number of ...haplotype analysis, haplotypes with variance less than 5 are ...haplotype analysis is to collapse rare haplotypes into one ...
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Comparing family based rare variant association tests for dichotomous phenotypes
... the analysis with population-based samples suffers from genetic ...variant association analysis with population-based samples might suffer from the genetic heterogeneity between ...
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Family based Bayesian collapsing method for rare variant association study
... [10], have been proposed for RV association detection. Because of the large scale of model space and matrix cal- culation, these approaches suffer from impractical com- putational time if a full joint posterior ...
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A multistep approach to single nucleotide polymorphism–set analysis: an evaluation of power and type I error of gene based tests of association after pathway based association tests
... pathway-based association tests can offer improvements in power for detecting association with phenotypes of interest, a significant pathway-based asso- ciation test does not indicate which of ...
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Quantifying the Relationship Between Gene Expressions and Trait Values in General Pedigrees
... the family-based microarray data ...the association of gene expres- and LR use full data in pedigrees; and (2) the FEXAT sions with multifactorial phenotypes of ...interest. Family- does not ...
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Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families
... for association analysis of dichotomous phenotypes with family-based samples [17, ...genetic association with family-based samples is tested by building a genotype ...
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Exploration and comparison of methods for combining population and family based genetic association using the Genetic Analysis Workshop 17 mini exome
... Epstein et al. [6] generalized this work by relaxing the assumptions of HWE, random mating, and the assumed multiplicative mode of inheritance. In addition, they described a formal test for the appropriateness of combin- ...
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A comparative analysis of family based and population based association tests using whole genome sequence data
... Both family-based and population-based analyses of whole genome sequencing data were evaluated for their power to detect associations with a simulated phenotype with variants in the MAP4 gene and on ...
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Diplotyper: diplotype-based association analysis
... haplotype-based association analysis in population and family samples using single nucleotide polymorphism (SNP) data ...haplotype association analysis in unrelated individuals ...
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Combining multiple family based association studies
... that association studies of some diseases, such as rheumatoid arthritis (RA), are being per- formed by more than one group of investigators, giving rise to multiple data sets ...linkage analysis, it is ...
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On family based genome wide association studies with large pedigrees: observations and recommendations
... One of the major challenges in these analyses was the computational time, especially for the MGA, where gen- ome-wide analyses are infeasible. MGA analysis took approximately 30 seconds per SNP, while the FBAT ...
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Association between social and family support and antenatal depression: a hospital based study in Chengdu, China
... is based on in- formation from the survey and related medical ...from analysis due to “20% blank” in the questionnaires or failure of completing questionnaire at both trimesters, leaving 996 women with ...
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