fine mapping
Bayesian Association-Based Fine Mapping in Small Chromosomal Segments
... for fine mapping is presented, which deals with multiallelic markers (with two or more alleles), unknown phase, missing data, multiple causal variants, and both continuous and binary ...
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Fine-mapping of the 1p11.2 breast cancer susceptibility locus
... To fine-map this locus, we genotyped 92 SNPs in a 900kb region (120,505,799 – 121,481,132) flanking rs11249433 in 45,276 breast cancer cases and 48,998 controls of European, Asian and African ancestry from 50 ...
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Fine mapping of satellite DNA sequences along the Y chromosome of Drosophila melanogaster: relationships between satellite sequences and fertility factors.
... a heavy signal at the translocation breakpoint and multiple sites of labeling on the long arm; the Y-distal element shows a heavy labeling on.. For the fine mapping of the [r] ...
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Fine Mapping of the Friend Retrovirus Resistance Gene, Rfv3, on Mouse Chromosome 15
... further mapping of these regions of the human chromosomes may uncover addi- tional candidate ...current fine mapping is that identification of Rfv3 by physical means is now ...
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Simultaneous Fine Mapping of Multiple Closely Linked Quantitative Trait Loci Using Combined Linkage Disequilibrium and Linkage With a General Pedigree
... QTL intensities from the multiple-QTL analysis are clearly highest at the true QTL positions, compared to the neighboring regions. The three QTL are clearly distinguishable and mapped at the correct positions. However, ...
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A strategy for QTL fine mapping using a dense SNP map
... is fine-mapped applying two variance com- ponent approaches combining both linkage analysis and linkage disequilibrium ...for fine-mapping linked and epistatic ...
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Fine mapping inflammatory bowel disease loci to single variant resolution
... the fine-mapping ...to fine-map it, we assumed that the association has only two causal variant candidates, and we defined the signal as successfully fine-mapped if the ratio of Bayes factors ...
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Multitrait Fine Mapping of Quantitative Trait Loci Using Combined Linkage Disequilibria and Linkage Analysis
... A novel multitrait fine-mapping method is presented. The method is implemented by a model that treats QTL effects as random variables. The covariance matrix of allelic effects is proportional to the IBD ...
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Coalescent-Based Association Mapping and Fine Mapping of Complex Trait Loci
... approach also produces a posterior probability that each We have described a new unified method, LATAG, for chromosome carries a disease mutation. This can be association mapping and fine mapping ...
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Comparing Linkage Disequilibrium-Based Methods for Fine Mapping Quantitative Trait Loci
... on a single marker is an effective method for LD-based by violations of these assumptions such as altering effec- fine mapping of QTL if a dense marker map is available. tive population size and the number ...
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QTL analysis for chalkiness of rice and fine mapping of a candidate gene for qACE9
... Up to now, many rice mutants associated with chalki- ness have been identified and a few genes have been cloned. Although only one QTL for chalkiness was cloned, many QTLs have been reported related to the trait. The ...
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Fine Mapping of a Quantitative Trait Locus for Twinning Rate Using Combined Linkage and Linkage Disequilibrium Mapping
... the fine-scale mapping of genes affecting complex traits, which combines linkage and linkage-disequilibrium information, is ...to fine map a QTL for twinning rate in cattle, previously mapped on ...
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Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain.
... The p2 region of the Rous sarcoma virus (RSV) Gag polyprotein contains an assembly domain, which is required late in replication for efficient budding of virus-like particles from cells (J. W. Wills, C. E. Cameron, C. B. ...
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Fine mapping of qBK1, a major QTL for bakanae disease resistance in rice
... Results: The genotypes/phenotypes of recombinants selected from backcrossed recombinant inbred lines of two rice varieties, Shingwang (resistant) and Ilpum (susceptible), indicated that [r] ...
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Fine mapping of antigenic site II of herpes simplex virus glycoprotein D.
... To determine which continuous epitopes are immunogenic in the native protein, synthetic peptides mimicking many regions of gD were screened with polyclonal sera prepared against purified[r] ...
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Fine-Mapping Of 1p36 Deletion, Related To The Manifestation Of Hirsutism
... Abstract: Rearrangements of 1p36 resulting in deletion are observed in 1 in 5,000 live births. Molecular characterisation of deletions, along with phenotypic correlations, have yielded regions in which to search for ...
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Fine mapping of genes within the IDDM8region in rheumatoid arthritis
... to fine map the IDDM8 region on chromosome 6q27, focusing on the genes in the region, to identify polymorphisms that may contribute to susceptibility to RA and potentially to other autoimmune ...
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Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
... The majority of susceptibility loci for breast and other cancers have been detected using studies of predominantly European an- cestry. However, confirmation of associations in populations with different ethnicity from ...
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Fine mapping of genes within the IDDM8 region in rheumatoid arthritis
... The total dataset analyzed in this study (354 cases and 372 controls) had the power to detect an effect size or odds ratio greater than 1.6; therefore, if the IDDM8 region conferred a risk similar to that of PTPN22 in RA ...
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Joint Linkage and Linkage Disequilibrium Mapping of Quantitative Trait Loci in Natural Populations
... nome mapping because the linkage disequilibrium de- ating the log-likelihood of Equation 5 with respect to each tected is ...the fine mapping of ...
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