free virions
A hunter virus that targets both infected cells and HIV free virions: Implications for therapy
... The design of ‘ hunter ’ viruses aimed at destroying human immunodeficiency virus (HIV) infected cells is an active area of research that has produced promising results in vitro. Hunters are designed to target exposed ...
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1 Pathogen at the Gates: HCMV Entry and Cell
... membrane fusion may explain why the trimer is required for the infectivity of cell-free virions in cellsA. 112.[r] ...
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Cholesterol Dependence of Varicella-Zoster Virion Entry into Target Cells
... In order to determine whether the cholesterol-dependent step occurs early in infection (compatible with entry), we rea- soned that the inhibitory effect of M  CD should be lost as the drug is added at progressively ...
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Quantitative molecular monitoring of human immunodeficiency virus type 1 activity during therapy with specific antiretroviral compounds
... cell-free virions showed that circulating viral variants bearing at least two mutations compatible with azidothymidine or ddI resistance were detectable in the patients who exhibited a rebound in ...
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Changes in anti-viral effectiveness of interferon after dose reduction in chronic hepatitis c patients: a case control study
... ion production ( ε ). Changes in other parameters, such as blocking de-novo infection (H) loss rate of infected cells ( δ ) and clearance rate of free virions (c), without a change in blocking production, ...
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Adaptability in herpesviruses: glycoprotein D-independent infectivity of pseudorabies virus.
... of free infectious virus are extremely ...of virions from in- fected cells and/or enhances the infectivity of cell-free virions is ...Pass, free virions could be isolated with ...
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Tetherin Inhibits Cell-Free Virus Dissemination and Retards Murine Leukemia Virus Pathogenesis
... In the present study, we reexamined the effects of tetherin on the spread of two enveloped viruses (MoMLV and vesicular stomatitis virus [VSV]) in vitro by using a novel live-cell imaging analysis of the simplest model ...
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Structure and Development of Viruses as Observed in the Electron Microscope
... Although moderate phagocysiderably fewer attached viral particles at the cell tosis and occasional free virions in the cytoplasm surface and only moderate numbers within were observed, t[r] ...
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Role of TAR RNA splicing in translational regulation of simian immunodeficiency virus from rhesus macaques.
... The ability of these splicing mutations to reduce the accumulation of both viral RNA and protein as well as the production of cell-free virions is most simply explained by a decrease in [r] ...
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Fuzzy Logic Approach for Solving an Optimal Control Problem of an Uninfected Hepatitis B Virus Dynamics
... increase of uninfected hepatocytes to its higher value during the first month of the beginning of the process be- fore decreasing to reach the wanted equilibrium value. This behaviour is due to action of therapeutic ...
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Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1
... MHC-negative virions stimulated an ex- cess of growth over apoptosis, whereas the MHC-positive viri- ons produced a net apoptotic depletion of ...into virions (5, ...MHC-negative virions, this result ...
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Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms
... of virions is important to understand, as this final step in the virus replication cycle produces infectious extracellular particles capable of spreading to the next round of host ...
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Selective Packaging of Host tRNA's by Murine Leukemia Virus Particles Does Not Require Genomic RNA
... The model was tested by comparing the free 4S RNA composition of normal murine leukemia virus MuLV particles and noninfectious virions from actinomycin D ActD-treated cells, which are de[r] ...
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Truncations of the simian immunodeficiency virus transmembrane protein confer expanded virus host range by removing a block to virus entry into cells.
... Virions containing the wild-type and mutant glycoproteins were capable of efficient replication in macaque peripheral blood lymphocytes and CEMX174 cells; in contrast, only virions that [r] ...
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Egress of varicella-zoster virus from the melanoma cell: a tropism for the melanocyte.
... VZV virions and the formation of cytoplasmic vacuoles by a combination of TEM, pulse-chase analysis, autoradiography, and cross-fire probability matrix analysis to identify individual subcellular ...
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Defective Virions of Reovirus
... Clones derived from stock virus should produce only H particles as should clones derived from H particles; if a plaque of stock virus were produced by an aggregate containing infectious [r] ...
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Binding of tryptophanyl-tRNA to the reverse transcriptase of replication-defective avian sarcoma viruses.
... The ability of the into virions is a temperature-sensitive process, mutant viruses to absorb the monospecific IgG and virions produced at 420C contain less re- can then be estimated by a[r] ...
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Factors affecting composition and thermostability of mengovirus virions.
... This report demonstrates that mengovirus virions produced at 31.50C have a detectable amount of two high-molecular-weight polypeptides that are not present in virions produced at 37.0 or[r] ...
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Phosphoprotein Component of Vaccinia Virions
... Tryptic peptides derived from the purified in vivo-labeled virion phosphoprotein and the purified in vitro reaction product of the viral protein kinase were analyzed on thin-layer cellul[r] ...
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Generation of H9 T cells stably expressing a membrane bound form of the cytoplasmic tail of the Env glycoprotein: lack of transcomplementation of defective HIV 1 virions encoding C terminally truncated Env
... released virions, the respective virions were concentrated by ultracentrifuga- tion from the media of infected H9-CT cells or H9-GFP cells and lysates of infected cells and virions examined in ...
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