Gene-Environment Interaction
Gene-Environment Interaction in Chronic Disease
... The identification of genetic or epigenetic asso- ciations with disease phenotypes facilitates risk stratification and can therefore help to guide mon- itoring and prevention. In order to convert these observations into ...
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Extraction of Gene Environment Interaction from the Biomedical Literature
... the gene-disease relation is sen- sitive to external factors, their identifica- tion is important to study a ...called Gene-Environment interaction (GxE), have been considered as impor- tant ...
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Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study
... of gene-environment interaction studies of lung function or lung function has fo- cused on gene by smoking interaction ...describe gene by occupational exposure ...by gene ...
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Effects of genetic and environmental factors and gene environment interaction on expression variations of genes related to stroke in rat brain
... and gene-environment interaction impact on the expression variations of genes related to stroke, we conducted microarray experiments using two ho- mozygous rat strains SHRSR and SHRSP fed with high ...
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A powerful statistical method identifies novel loci associated with diastolic blood pressure triggered by nonlinear gene environment interaction
... factors. Gene-environment interaction is assumed to play an important role in determining individual blood pressure ...which gene shows sensitivity to aging in its effect on blood pressure is ...
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Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study
... a gene-environment interaction between iron metabolism genotype and MBL by regressing log-transformed values of UCBL on similarly- transformed values of ...respective interaction with MBL, ...
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Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
... the gene– environment interaction analysis, the TLR2 rs3804099/ Toxoplasma interaction shows a trend in that the TLR2 genetic variation may modulate the relationship between Toxoplasma gondii ...
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Gene–Environment Interaction Effects of Peer Deviance, Parental Knowledge and Stressful Life Events on Adolescent Alcohol Use
... The purpose of this study was to address two methodological issues that have called into question whether previously reported gene–environment interaction (GxE) effects for adolescent alcohol use are ...
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Gene environment interaction impacts on heart development and embryo survival
... a gene-environment interaction (GxE) between genetic predisposition to vertebral segmentation defects and short- term gestational hypoxia (Sparrow et ...
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Gene environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis
... and result in exaggerated risks. Nevertheless, this was unlikely to have affected our findings since the TGF b 1 polymorphisms we examined did not deviate from Hardy- Weinberg Equilibrium (HWE) in the control population. ...
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Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures
... potential gene – environment ...and gene – environment inter- ...and gene – environment interaction effects by combining the advantages of both longitudinal studies for ...
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Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants
... homozygous models, were not examined because of the limited information in the meta-analysis of individuals in the presence of radiation exposure. Therefore, the gene- environment interaction in ...
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Gene environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis
... and result in exaggerated risks. Nevertheless, this was unlikely to have affected our findings since the TGF b 1 polymorphisms we examined did not deviate from Hardy- Weinberg Equilibrium (HWE) in the control population. ...
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Gene-Environment Interaction in Type II Diabetes
... is gene-environment ...the interaction between genetic and environment ...that interaction between the genetic and environment factors have been significantly associated with ...
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ASSOCIATION AND GENE-ENVIRONMENT INTERACTION EFFECT OF VEGFR-2 GENE POLYMORPHISM WITH MENTAL HEALTH ON METABOLIC RISK FACTORS OF CARDIOVASCULAR DISEASE IN CHINESE MALAYSIAN FEMALE ADULTS
... candidate gene and related polymorphism, our previous study on the genetic associations involving VEGFR-2 gene rs2071559 polymorphism has shown significant results on the metabolic risk factors of CVD, ...
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Genetic association analysis of coronary heart disease by profiling gene environment interaction based on latent components in longitudinal endophenotypes
... The repeated measures of multiple coronary heart disease (CHD)-related phenotypes from Genetic Analy- sis Workshop (GAW) 16 Problem 2 are ideal for testing this approach to identify genetic variants that interact with ...
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Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example
... in asthma, the response to oxidative stress is of major interest: the amount of biological evidence of the role of oxidative stress in asthma is increasing [7], and tobacco smoke is related to oxidative stress. Tobacco ...
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Gene environment interaction in the conversion of a mild to severe phenotype in a patient homozygous for a Ser172 >Cys mutation in the lipoprotein lipase gene
... LPL gene causing complete LPL deficiency have been described, but naturally occurring mutations that result in defective LPL with partial activity have not yet been ...
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Pattern based mining strategy to detect multi locus association and gene × environment interaction
... described in this report, we applied the pattern-based method on the chromosome 18 data set on rheumatoid arthritis (RA) ascertained by the North American Rheuma- toid Arthritis Consortium (NARAC) that was made avail- ...
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Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice
... GXE interaction may increase AD risk, there is little direct evidence supporting this hypoth- ...GXE interaction between lead and ApoE4 on cognitive ...
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