gene inactivation
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation
... to inactivation of the shelterin gene Acd, encoding ...Acd inactivation, HSCs expressed p53 target genes, underwent cell cycle arrest, and were severely depleted within days, leading to hematopoietic ...
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The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila
... Transgenes in the same region (e.g., the abovementioned 11127 and 20102) (Figure 3, region C) can be inactivated or not, respectively, and we suppose that heterochromatin for- mation proceeds autonomously on a transgene ...
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Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma
... TP53 gene (IVS6-36G > C) is located in in- tron 6 of the ...in gene coding sequence leads to the survival of cells after chemotherapy and inhibits apop- tosis for a long period ...
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Vacuolar ATPase of Neurospora crassa: electron microscopy, gene characterization and gene inactivation/mutation
... 2 Genes encoding three of the major subunits of the vacuolar ATPase and the homologous subunits of the mitochondrial FATPase have been isolated.. The exon/intron structures of the genes [r] ...
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Defining Gene Phenotype Relationships in Acinetobacter baumannii through One Step Chromosomal Gene Inactivation
... Construction of a recombineering system for A. baumannii. The purpose of this study was to develop a recombineering system in A. baumannii and show its utility in elucidating gene- phenotype relationships. We ...
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MECHANISMS OF CHROMOSOMAL AND GENE INACTIVATION IN DROSOPHILA
... If position-effect variegation involves suppres- sion of transcription, then one should obtain variegated transcription of the rDNA which is located in the heterochromatic region at [r] ...
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EVIDENCE FOR GENE INACTIVATION IN THE VIRUS-INDUCED ABERRANT RATIO PHENOMENON IN MAIZE
... One might also note that, in cross 1, the segregation from the reciprocal paired-plant crosses between AR parents is close to the normally expected ratio of 1 A : l a ; with t[r] ...
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Plasminogen activator inhibitor 1 gene deficient mice II Effects on hemostasis, thrombosis, and thrombolysis
... (PAI-1) gene inactivation on hemostasis, thrombosis and thrombolysis were studied in homozygous PAI-1-deficient (PAI-1-/-) mice, generated by homologous recombination in D3 embryonic stem ...
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Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer
... recessive gene, inactivation of an allele does not necessarily compromise its function entirely, as it can express itself partially ...as inactivation due to methylation of promoter areas is one of ...
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Bacterial Evolution Through the Selective Loss of Beneficial Genes: Trade-Offs in Expression Involving Two Loci
... or gene activities during evolution. Gene inactivation is strate a fitness advantage when competed ...against gene occupy different niches in stationary-phase ...
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Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster
... nocamycin gene cluster Saccharothrix syringae NRRL B-16468 genome was shotgun sequenced by Hiseq4000 technologies and the sequence reads were assembled into ...PKS-NRPS gene cluster designated as Ncm seems ...
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Four Non-functional FUT1 Alleles Were Identified in Seven Chinese Individuals with Para-Bombay Phenotypes
... The inactivation of the FUT1 gene happened af- ter FUT2 gene inactivation, as all of the Bombay and nonsecretor para-Bombay individuals had the same inactivated FUT2 allele but possessed dis- ...
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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
... muscle-specific inactivation of the insulin receptor gene (muscle-specific insulin receptor knockout [MIRKO] mice) and demonstrated more than a 95% decrease in muscle insulin ...
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Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy
... X inactivation patterns in the proband showed that her paternal X chromosome was always active and that her maternal X chromosomes carrying the 173 allele (with M1 and the 163-104-173-202-135 haplo- types) were ...
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The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
... RAD52 gene seems to be involved in all HR events including single-strand annealing and gene conversion ...this gene compared to other mutants of the same group ...
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Condensin Depletion Causes Genome Decompaction Without Altering the Level of Global Gene Expression in Saccharomyces cerevisiae
... global gene expression program is largely unaffected by condensin depletion in cycling ...in gene expression in ycs4-2 and ycg1-2 ...of gene expres- sion during quiescence (Swygert et ...
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Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type
... SMARCA4 gene appear to be associ- ated with various cancers including malignant melanoma, non-small cell lung cancer, head and neck and pancreatic cancer ...the gene locus in this ...SMARCA4 gene ...
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Adenovirus type 2 VAI RNA transcription by polymerase III is blocked by sequence-specific methylation.
... We used the Ad2 VAI region as a model to demonstrate that the sequence-specific methylation of an RNA polymerase ITT-transcribed gene leads to transcriptional inactivation upon transfect[r] ...
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Epithelial innate immunity mediates tubular cell senescence after kidney injury
... senescence might be induced in the kidney after injury and that this might contribute to progressive organ fibrosis. Testing this hypothesis, we found that tubular epithelial cells (TECs) in mice senesce within a few ...
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Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell
... candidate gene fulfilling this function should start to be expressed in a subpopulation of venous ECs at ...functional inactivation should result in the absence of LECs, and it would probably not be ...
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