Gene interactions
Combining least absolute shrinkage and selection operator (LASSO) and principal components analysis for detection of gene gene interactions in genome wide association studies
... Eleven gene-gene interactions were suggested from the LASSO-SNP method, while three of these gene-gene interactions were suggested from the LASSO-PCA ...significant ...
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Detecting gene-gene interactions using a permutation-based random forest method
... the interactions have been used [35]. Early methods to detect interactions include the logistic regression model with interaction terms, joint tests of association and exhaustive searches, but, with good ...
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Tumor dormancy in population of cancer stem cells: gene interactions by bioinformatics
... of gene interaction of cancer stem cells and tumor dormancy, as well as to evaluate the gene interactions carried out by genes related to tumor dormancy in the cancer stem cell ...
7
Detecting gene-gene interactions in prostate disease in African American men
... direct gene-gene interactions were found, however the most significant interactions were observed on chro- mosome 1 and chromosome ...ABCD3 gene involvement in African Ameri- can ...
10
Functional dyadicity and heterophilicity of gene-gene interactions in statistical epistasis networks
... Our methodology itself has great application potential in genetic association studies. It can be used to analyze and interpret the gene-gene interactions for a wide range of phe- notypes or diseases. ...
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Grammatical evolution decision trees for detecting gene-gene interactions
... including gene-gene ...model gene-gene ...representing gene-gene interaction models of a range of effect ...detect interactions with and without main ...
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Quantile regression analysis reveals widespread evidence for gene-environment or gene-gene interactions in myopia development
... A genetic contribution to refractive error has been confirmed by the discovery of more than 150 associated variants in genome-wide association studies (GWAS). Environmental factors such as education and time outdoors also ...
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Identification of multiple gene-gene interactions for ordinal phenotypes
... causal gene-gene interactions are searched for complex traits in a genome-wide ...of gene-gene interactions in OMDR as well as MDR ...for gene-gene ...
9
An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics
... In this study we have examined how gene-gene interactions can affect the ability to detect trait-associated loci in cell-based, dose-response association studies. We have presented a novel ...
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ITPKC and SLC11A1 Gene Polymorphisms and Gene Gene Interactions in Korean Patients with Kawasaki Disease
... ciated gene, and solute carrier 11a1 (SLC11A1), which is associated with the hypersensitive reaction to the BCG strain in ...evaluated. Gene-gene interactions between ITPKC and SLC11A1 in KD ...
9
Artificial neural networks for linkage analysis of quantitative gene expression phenotypes and evaluation of gene × gene interactions
... selected gene expression phenotypes from 14 CEPH (Centre d'Etude du Polymorphisme Humain) pedigrees provided for Genetic Analysis Workshop 15 (GAW15), we analyzed quantitative traits with artificial neural ...
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Two stage strategies to detect gene × gene interactions in case control data
... of gene × gene interactions in such studies is a sensible method of capturing important genetic ...Most interactions detected resulted from SNP pairs within 1000 kb of each ...
5
Gene-gene interactions in gastrointestinal cancer susceptibility
... multi-layer interactions between diverse genetic and environmental ...showing gene-gene interactions, also known as epistases, affecting genetic susceptibility in colorectal, gastric and ...
14
LDGIdb: a database of gene interactions inferred from long range strong linkage disequilibrium between pairs of SNPs
... human gene interactions ...uncharacterized gene interactions, in which the functional associations between the LDGI genes may not be explicitly indicated in other biological ...
8
Original Article Association of estrogen receptor alpha gene polymorphisms and its gene-gene interactions with knee osteoarthritis susceptibility in Chinese Han population
... (ESR1) gene polymorphisms and its gene-gene interactions with knee osteoarthritis (OA) ...ESR1 gene and knee OA risk and additional gene- gene interaction between ...
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THE MUTATIONAL LOAD WITH EPISTATIC GENE INTERACTIONS IN FITNESS
... The situation is intermediate for a random mating population of a hypothetical organism having only one pair of chromosomes within which no crossing over takes place.-The m[r] ...
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Spatially Uniform ReliefF (SURF) for computationally-efficient filtering of gene-gene interactions
... single- gene effects is difficult however, and methods to exhaustively analyze sets of these variants for interactions are combinatorial in nature thus making them computationally ...
9
Allelic based gene gene interactions in rheumatoid arthritis
... of gene-gene interaction has been challenging due to an issue of high dimensionality from multi-locus combinations that require a large sample ...detect gene-gene interaction influencing RA ...
7
Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes
... [7] gene filtration technique to detect the patterns of k -way GxG interaction among m genes (SNPs) and re- move noisy genes (SNPs) with little interactive effects to determine the optimal number of SNPs for the ...
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A model of gene-gene and gene-environment interactions and its implications for targeting environmental interventions by genotype
... no gene-gene interactions (epistasis); (ii) there are no gene-environment interac- tions; (iii) the effects of environmental factors shared by twins are independent of zygosity (the 'equal ...
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