Gene regulatory network
Wnt6 activates endoderm in the sea urchin gene regulatory network
... Experiments with -catenin first suggested that the canonical Wnt pathway is involved in activation of the endomesoderm GRN (Emily-Fenouil et al., 1998; Wikramanayake et al., 1998; Logan et al., 1999). Exploring this ...
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Gene regulatory network state estimation from arbitrary correlated measurements
... feedback gene regulatory network [17, 18]. The p53 gene codes for the tumor suppressor protein p53 in humans, and its activation plays a critical role in cellular responses to various stress ...
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Mean field analysis of a spatial stochastic model of a gene regulatory network
... In future work we will consider investigating higher order moments in order to quantify the variance for each model species. It is often the case that transcription factors can not function in monomer form (as we have ...
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Multilayer Perceptron based Model of Large Scale Gene Regulatory Network
... large Gene Regulatory Network ...constructing gene regulatory network unlike creating hypothetical connections by using conditional combinations of gene as input or using ...
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Sub circuits of a gene regulatory network control a developmental epithelial mesenchymal transition
... Transcriptional regulatory state changes must ultimately coordinate the timing and execution of these cell biological ...characterized gene regulatory network (GRN) in the sea urchin embryo ...
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A direct role for murine Cdx proteins in the trunk neural crest gene regulatory network
... Numerous studies in chordates and arthropods currently indicate that Cdx proteins have a major ancestral role in the organization of post- head tissues. In urochordate embryos, Cdx loss-of-function has been shown to ...
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Investigating the transcriptional mechanisms controlling Sfpi1, a critical regulatory node within multiple lineage specifying subcircuits of the hematopoietic gene regulatory network
... Runx1 is a pivotal regulator of blood development. As discussed in chapter 1, Runx1 deficiency results in a lack of definitive hematopoiesis. That deficiency is due at least in part to lack of PU.1 expression. While ...
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Regulative deployment of the skeletogenic gene regulatory network during sea urchin development
... the network in transfating cells in greater detail, we first focused on the activation of two other early genes in the network: delta and ...skeletogenic gene regulatory network ...
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Genome wide analysis of the skeletogenic gene regulatory network of sea urchins
... genomic regulatory control of morphogenesis. A transcriptional gene regulatory network (GRN) that underlies the specification of skeletogenic cells (primary mesenchyme cells, or PMCs) has ...
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Role of Feedback and Dynamics of a Gene Regulatory Network
... galactose gene-regulatory network (GAL) in Saccharomyces cere- visiae ...galactose regulatory network is a very well analyzed eukaryotic gene circuit that provides cells with the ...
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Learning Gene Regulatory Network from Microarrays Based on Bayesian Network
... Bayesian network for lung ...important gene in the disease of lung ...microarray gene expression data and construct clean and straightforward gene regulatory network with high ...
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Modeling multiple time units delayed gene regulatory network using dynamic Bayesian network.
... mine gene regulatory network from gene expression ...between gene pairs with a high mutual information above a ...Boolean network was first applied to model gene ...
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A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis
... tree-like regulatory hierarchy of binary cell fate decisions between cell lineages or rather a more network-like situation where a particular cell lineage can arise in alternative pathways from different ...
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A branching gene regulatory network dictating different aspects of a neuronal cell identity
... Fig. 1. Co-misexpression of col and lbe results in ectopic Tv1 cells. (A) Nplp1-CRM-myrRFP (RFP false coloured in green) and FasII expression at stage AFT reveal the axon projections of the Nplp1-positive neurons. myrRFP ...
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Statistical and Gene Regulatory Network Analysis of Monolignol Biosynthetic Genes in Populus trichocarpa.
... single gene PtrCCR2 is active in monolignol biosynthesis in SDX of ...target gene expression, observed as reduced transcript ...target gene results in a modification in the expression of other genes ...
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Inferring Drosophila gap gene regulatory network: pattern analysis of simulated gene expression profiles and stability analysis
... The long-term dynamics of the circuits should show if the model is able to predict the disappearance of the gap gene domains, and provide information about the asymptotic stability of the model and potentially ...
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Lessons from a gene regulatory network: echinoderm skeletogenesis provides insights into evolution, plasticity and morphogenesis
... the regulatory genes of the skeletogenic GRN are normally expressed both by PMCs and NSM cells, including ets1, erg, tel, hex, snail, foxN2/3 and foxO, which suggests that there are many similarities in the ...
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NIMEFI: gene regulatory network inference using multiple ensemble feature importance algorithms
... a network instead of a ranking while others leave the decision to the ...the network at various threshold levels. Some parts of the network can have a weaker signal in the gene expression set, ...
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A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos
... We sought to determine the role that each of these genes has in establishing these domains. Our goal is to understand how these territories in turn may regulate neurogenesis. We first examined the role of foxq2 in ...
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Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus
... transcriptional regulatory network for podocyte ...single gene regulated the entire differentiation ...podocyte gene expression within the glomus ...podocyte gene expression ...
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