geographic atrophy
Geographic atrophy in patients with advanced dry age-related macular degeneration: current challenges and future prospects
... Abstract: Geographic atrophy (GA) of the retinal pigment epithelium (RPE) is a devastating complication of age-related macular degeneration (AMD). GA may be classified as drusen- related (drusen-associated ...
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Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules
... The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and ...
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Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO)
... Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO).. A [r] ...
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<p>Multimodal Evaluation of Visual Function in Geographic Atrophy versus Normal Eyes</p>
... As the aging population continues to grow, geographic atrophy, the advanced form of dry AMD, looms large as a major cause of severe, central vision loss. Given the lack of treatment options to prevent GA, ...
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Visual rehabilitation via microperimetry in patients with geographic atrophy: a pilot study
... no definitive treatment to reverse geographic atrophy progression [3]. Recent clinical trials investigated or are developing therapies through multiple modalities including complement system and ...
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Potential role of lampalizumab for treatment of geographic atrophy
... in geographic area from baseline to month 18 on fundus ...in geographic area assessed by color fundus photographs, and mean change from baseline in Early Treat- ment Diabetic Retiropathy Study (ETDRS) best ...
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Type 1 neovascularization may confer resistance to geographic atrophy amongst eyes treated for neovascular age-related macular degeneration
... graphic atrophy (GA) in one eye receiving frequent intravitreal injections of anti‑vascular endothelial growth factor (anti‑ VEGF) therapy for type 1 neovascularization (NV) was slower than that of the fellow eye ...
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<p>Burden of Illness in Geographic Atrophy: A Study of Vision-Related Quality of Life and Health Care Resource Use</p>
... Methods: This cross-sectional study with a retrospective chart review involved patients aged ≥ 70 years with physician-con fi rmed bilateral symptomatic GA due to age-related macular dege[r] ...
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Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review
... Studies have suggested that the alternative comple- ment pathway and membrane attack complex (MAC) in the choroid also play key roles in the pathogenesis of AMD and GA [32]. Mullins et al. postulated that the de- ...
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Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye
... without geographic atrophy (five), exudative AMD (three), retinal vein occlusion (two), diabetic retinopathy (one), retinoschisis (one), myopic degeneration (one), pattern dystrophy (one), and epiretinal ...
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Spotlight on reticular pseudodrusen
... 72. Querques G, Souied EH. Correspondence. Retina. 2015;35(1):e4–e6. 73. Steinberg JS, Auge J, Jaffe GJ, Fleckenstein M, Holz FG, Schmitz- Valckenberg S; GAP Study Group. Longitudinal analysis of reticular drusen ...
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Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration
... Ten patients were identified; three had a prior RPE rip and were excluded from the study. Thus, seven eyes from 7 patients (5 females) met the inclusion criteria. Demo- graphic characteristics, ocular manifestation and ...
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Original Article A distinct form of retinitis pigmentosa with retinal vascular occlusion
... surement of VEP showed that optic nerve func- tion was seriously compromised. Third, RPE atrophy was prominent and occurred with or without the presence of fine pigmented spots; there were no deposits resembling ...
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Onset and Progression of Pathologic Atrophy in Huntington Disease: A Longitudinal MR Imaging Study
... Caudate atrophy rates were linear, with no evidence of acceleration, and were ap- proximately 10-fold higher in patients than in ...caudate atrophy rates among patients regardless of their disease ...
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MR changes in transverse myelitis
... icits does not meet current DAT diagnostic criteria. By definition, elderly subjects who receive GDS scores of 3 or scores of 0.5 on the Clinical Dementia Rating (7) are considered to have MCI. Prior longitudinal work in ...
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Rotigotine is safe and efficacious in Atypical Parkinsonism Syndromes induced by both a-synucleinopathy and tauopathy
... Recently there has been growing attention in trying to identify a possible therapy for sporadic APS conditions. The monoamine oxidase-B inhibitor rasagiline (1 mg/day) was administered for 48 weeks in 174 patients with ...
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Diffusion and Perfusion MR Imaging in Cases of Alzheimer's Disease: Correlations with Cortical Atrophy and Lesion Load
... METHODS: Thirty-nine participants were studied: 18 patients with moderate cognitive im- pairment with probable Alzheimer’s disease, 16 patients with mild impairment with possible or probable Alzheimer’s disease, and 15 ...
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Key words
... no atrophy was observed and in only one animal it was completely ...(+) atrophy, the distance between mus- cle fiber increased minimally and the diameters were similar to each other ...(++) atrophy ...
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Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study
... cortical atrophy in the HC ...cortical atrophy is modestly related to microstructural changes of the SDGM in HC ...matter atrophy in MS groups but not with cortical ...
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The mucopolysaccharidoses: characterization by cranial MR imaging
... Cribriform changes Supraventricular brain Corpus callosum Basal ganglia Total score Atrophy and ventricular enlargement Atrophy Ventricular enlargement Total score Myelination delay and [r] ...
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