Germline stem-cells
Effete mediated degradation of Cyclin A is essential for the maintenance of germline stem cells in Drosophila
... It has been shown that APC/C activity is required for the asymmetric localization of Miranda and its cargo proteins during neuroblast division (Slack et al., 2007). In Drosophila ovary, previous studies have demonstrated ...
10
Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary
... study stem cell maintenance and differentiation because all of the steps unfold in well-defined ...three germline stem cells (GSCs) are attached by adherens junctions to niche cap cells ...
6
Mei P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling
... maintain germline stem cells (GSCs) in an undifferentiated ...promoting germline cyst development. Within undifferentiated germ cells, Mei-P26 associates with miRNA pathway components ...
10
The centrosome orientation checkpoint is germline stem cell specific and operates prior to the spindle assembly checkpoint in Drosophila testis
... male germline stem cells (GSCs) possess a checkpoint mechanism that coordinates cell polarity and cell division (Cheng et ...hub cells, which constitute the major component of the stem ...
8
PAX7 expression defines germline stem cells in the adult testis
... of stem cell numbers in the donor ...rare) stem progenitors in the adult ...of stem progenitors (1, 8, ...mirror stem cell functionality in the undisturbed testis. Donor germ cells are ...
17
Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
... more cells, and there were slightly more single germ cells with a spectrosome around the hub cells ...germ cells (data not ...germ cells during early gonadal development. Extra single ...
11
Without children is required for Stat mediated zfh1 transcription and for germline stem cell differentiation
... cap cells (CC) are at the anterior (left). Germline stem cells (GSCs) and their daughters (cystoblasts, CBs) carry spherical fusomes ...(yellow). Germline cysts contain branched fusomes ...
9
Rapid population wide declines in stem cell number and activity during reproductive aging in C elegans
... the germline declines early in adult life, we applied state-of-the-art techniques to characterize the cellular and molecular changes that underlie age-related functional decline using sperm- replete animals before ...
15
Human endometrial mesenchymal stem cells restore ovarian function through improving the renewal of germline stem cells in a mouse model of premature ovarian failure
... germ cells and the surrounding somatic cells, however, chemother- apy could destruct the ovarian niches, decrease granu- losa cell function and induce ovarian toxicity ...transplanted stem ...
13
Germline stem cells and sex determination in Hydra
... of germline stem cells (GSCs) in Hydra is determined in a cell-autonomous ...sperm-restricted stem cells (SpSCs), while females have egg-restricted stem cells ...
10
Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling
... of stem cell homeostasis; however, the underlying mechanisms of this regulation are not fully ...ovarian germline stem cells (GSCs) by promoting the extension of niche escort cell (EC) ...
13
The control of sexual identity in the Drosophila germline
... discuss germline sexual identity within the context of the different stages of germline sexual development and the decisions that germ cells face along the way (see Box 1 for a discussion of ...of ...
9
Self maintained escort cells form a germline stem cell differentiation niche
... ovary, germline stem cells (GSCs) in the niche continuously self-renew and generate differentiated germ cells that interact physically with escort cells ...escort stem ...
11
Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche
... testis, germline stem cells (GSCs) and somatic cyst stem cells (CySCs) are arranged around a group of postmitotic somatic cells, termed the hub, which produce a variety of growth ...
7
Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche
... Cap cells and the terminal filament (TF) are shown in magenta and pink, ...suboptimal stem cell (GSC, gray) located next to an optimal stem cell (GSC, white) is forced to ...optimal stem cell ...
12
Germline stem cells in the Drosophila ovary descend from pole cells in the anterior region of the embryonic gonad
... the stem cell fate is initially determined during germline development remains ...cap cells become GSCs in pupal and adult ovaries (Deng and Lin, 1997; King, 1970; Zhu and Xie, 2003), and it remains ...
11
Kmt2b conveys monovalent and bivalent H3K4me3 in mouse spermatogonial stem cells at germline and embryonic promoters
... the cells were transferred onto mitomycin C-inactivated mouse embryonic fibroblasts (MEFs) and maintained in GS medium or serum-free ...floating cells were collected to remove MEFs and used for counting ...
10
Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary
... the germline is not only necessary to maintain a stable population of GSCs, but is also sufficient to specify stem cell ...support cells to preserve GSCs, most probably by regulating dpp (but not ...
8
The glypican Dally is required in the niche for the maintenance of germline stem cells and short range BMP signaling in the Drosophila ovary
... on germline stem cell (GSC) self-renewal, which is also restrained to its proper position to avoid the risk of ...(TF) cells, cap cells and escort stem cells (ESCs) (Decotto and ...
9
A Pak regulated cell intercalation event leading to a novel radial cell polarity is involved in positioning of the follicle stem cell niche in the Drosophila ovary
... negative cells as well as ectopic LanA in Pak mutant ...follicle cells produced by the ‘ unused ’ FSCs contributing to formation of the aberrant stalk ...
10