globin gene expression
Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence
... β- globin gene. Increasing the expression of the γ -globin gene has great benefits in reducing complications associated with these ...γ-globin gene. The human γ ...
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Globin gene expression in erythroid human fetal liver cells
... human globin mRNAs in liver samples from several mid-gestational ...alpha globin genes were present in fetal liver samples isolated from 10-25-wk ...human globin mRNAs declined in older fetuses, ...
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Compensatory increase in alpha 1 globin gene expression in individuals heterozygous for the alpha thalassemia 2 deletion
... normal individuals and in individuals heterozygous for the common 3.7-kilobase deletion within the alpha-globin gene cluster that removes the alpha 2-globin gene (the rightward type ...
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Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
... between gene-rich zones I and III in both lymphoid and erythroid ...alpha-globin gene domain (zone III of the studied region) with the USP7-ABAT locus (zone I), and the spatial separation of the ...
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Original Article β-thalassemia for translating human β-globin gene and RNA interference of α-globin gene expression by lentivirus vectors
... and gene silencing function will be more stable and continuously expressed in vitro and in vivo tests, which is more benefit to use in the gene therapy with better safety than the previous ...and ...
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Changing Pattern of Histone H3 Methylation following treatment of erythroid progenitors derived from cord blood CD133+ cells with sodium butyrate and thalidomide
... the gene-switching phenomenon during the developmental stages from embryonic to maturity is important in order to change the type and amount of hemoglobin in each stage of development and thus perform associated ...
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Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation
... α- globin chains in erythroid precursors, resulting in betterment of the imbalance between α and β chains ...of globin gene ...alter globin gene expression by affecting the ...
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Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene
... -globin gene cluster lead to specific syndromes characterized by increased production of fetal hemoglobin in adult life and provide a useful model to delineate novel cis-acting elements involved in the ...
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PubMedCentral-PMC4739742.pdf
... -like globin mRNA in mouse embryonic erythroid ...bin gene. The amount of KLF1 expression strongly positively correlates with β -globin mRNA and weakly positively correlates with BCL11A ...
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Spatial organization of the chicken beta-globin gene domain in erythroid cells of embryonic and adult lineages
... β-globin gene domain [4] suggested that the expression of one of the embryonic genes (ρ) is controlled by the LCR, while the expression of the other embryonic gene (ε) is controlled by ...
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Molecular basis of alpha-thalassemia
... Other mutations may alter the structure of the globin chain a ff ecting the stability of the αβ-dimer or tetramer. A few examples of highly unstable Hb variants are Hb Evora, Hb Heraklion, Hb Dartmouth, Hb Quong ...
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Activation of the human beta globin promoter in K562 cells by DNA sequences 5' to the fetal gamma or embryonic zeta globin genes
... beta-globin gene in these ...beta-globin gene. The gene appeared to be inducible with hemin. A zeta-globin 5' flanking fragment also activated the beta ...resistance gene, ...
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Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts.
... 2368 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We constructed nondefective herpes simplex virus type 1 recombinants bearing the intact rabbit beta-globin inserted[r] ...
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The expression of embryonic globin mRNA in a severely anemic mouse model induced by treatment with nitrogen-containing bisphosphonate
... hemoglobin expression have been identified [5, ...embryonic globin. These results indicate that KLF1 and KLF2 regulate the expression of β-like embryonic ...the expression of Gata1 and Bcl11a ...
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Common Beta-Thalassemia Mutation and virological study of Beta -thalassemic patients. Review Article
... Beta-thalassemia is a group of inherited blood disorder characterize by compact or absent beta globin chain synthesis, resulting in chronic hemolytic anemia and unproductive erythropoiesis. Persons with ...
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Development and validation of a high throughput, closed tube method for the determination of haemoglobin alpha gene (HBA1 and HBA2) numbers by gene ratio assay copy enumeration PCR (GRACE PCR)
... reference gene, followed by melting analysis has been described for the Adenomatous Polyposis Coli (APC) gene ...novel gene ratio assay copy enu- meration (GRACE) screening test for the simultaneous ...
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Coordinate expression of heme and globin is essential for effective erythropoiesis
... in expression of both heme synthesis and degradation genes during erythroid differentiation compared with control ...the expression of func- tional Flvcr1 isoforms (those containing exon 3) are ablated in ...
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Developmental regulation of hemoglobin synthesis in the green anole lizard Anolis carolinensis
... of gene duplication and divergence have given rise to families of - and - like globin genes that are ontogenetically regulated, such that functionally distinct Hb isoforms (isoHbs) are synthesized in ...
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New amber mutation in a beta thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo
... beta-thalassemia gene that carries a novel nonsense mutation in a Chinese ...the expression of this cloned gene in a transient expression system demonstrated a 65% decrease in levels of ...
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Polymorphism and Gene Conversion in Mouse α-Globin Haplotypes
... coding regions.. G., 1974 Rodent hemoglobin structure: a comparison of several species of mice. Assignment of orthol- ogous relationships among mammalian a-globin genes by ex- a[r] ...
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