High-throughput drug screening
Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening
... used drug, ribavirin, has limited efficacy and can cause severe side ...for high-throughput screening ...enables screening of small-molecule libraries under biosafety con- tainment ...
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Development of a high throughput drug screening assay to identify compounds that protect oligodendrocyte viability and differentiation under inflammatory conditions
... Other hits have been evaluated or will soon be tested in human MS trials. QTP (Seroquel XR ® ), an antipsychotic approved for schizophrenia is currently in clinical trials to determine tolerability to people with RRMS ...
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High Throughput Screening For Drug Discovery In Head And Neck Squamous Cell Carcinoma
... of drug on day 1 of high throughput drug screening and the 48 hour incubation period, alamarBlue was added to each well (5%) (Beckman BioMek FX) and allowed to incubate for 4 hours ...
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A microfluidic spheroid culture device with a concentration gradient generator for high-throughput screening of drug efficacy
... maintained high-cell ...for high-throughput spheroid formation, culture assessments, and drug efficacy tests ...a high-throughput drug screening brain cancer chip ...
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A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
... a high-throughput, reproducible fashion with minimal effort and training ...to high throughput screening of a range of developmental stages of different human and livestock helminth ...
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Exploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer
... There are two highly specific PI3Kα inhibitors, GDC- 0032 (Genetech) and BYL719 (Novartis) that have dem- onstrated superior inhibition of PIK3CA mutant and amplified cell lines as well as tumor xenografts [27,28]. ...
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High-throughput screening to enhance oncolytic virus immunotherapy
... impact of 2,640 bioactive compounds across three pharma- cologically active libraries on the replication index of the oncolytic HSV-1, G47 Δ (Table 1). From this library, 15 drugs were identified that amplified viral ...
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The discovery of potent ribosomal S6 kinase inhibitors by high- throughput screening and structure-guided drug design
... a high-throughput screening (HTS) campaign against S6K1 using an amplified luminescent proximity homogeneous assay, and the subsequent hit evaluation for the three hit series we ...
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Identification of new drug candidates against <em>Borrelia burgdorferi</em> using high-throughput screening
... During screening, the last two rows in the 384-well plate were taken as control by not adding any ...The screening was repeated for seven times with a titration range from ...each drug is tested at ...
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High-Throughput Screening: Effective Tool in Drug Discovery
... glycosylation all affect chromatographic behavior. The modified peptides must be separated from the native peptides for a peptide mapping method to be useful. The presence of a modified peptide in the map of a sample ...
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Molecular docking and High throughput screening of potent inhibitor to gp46SU involved in ATLL through drug design studies
... computational drug designing and docking studies on HSPG binding domain of gp46SU of env ...out high throughput screening and molecular docking on 446 molecules from scaffolds ...selected. ...
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Identification of novel ‘inks’ for 3D printing using high throughput screening: bioresorbable photocurable polymers for controlled drug delivery
... printability screening, an ink predicted to not be printable from the high throughput test (BA3 in Table 1) was checked for dispensing, and was found not to be printable on the Dimatix DMP 2800 by ...
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Development of automatic image analysis methods for high-throughput and high-content screening
... In order to validate the sensitivity of our algorithm for perturbation of the biological system, a pilot experiment was performed by pre-exposing the HepG2/GFP-p65 cells for 2 hours with increasing concentrations of an ...
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Clinical application of high throughput molecular screening techniques for pharmacogenomics
... and Drug Administration (FDA)- cleared as showing substantial equivalence to a previously approved device or fully approved by the FDA as new in vitro diagnostic ...
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High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§
... In this study, workflows, methods and software have been developed to allow efficient high-volume compound screening of 25 proteins by SPECT/CT of a tumour xeno- graft mouse model. The main interest of this ...
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6203.pdf
... In order to successfully predict and model biological endpoints, data is needed to anchor and validate toxicities predicted by computational toxicology. Although a recent transformation for the field of regulatory ...
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A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening
... in drug targets that are known to be used for the treatment of rheumatoid arthritis ...for drug target identification, their relatively low coverage, due to low-throughput screening and/or low ...
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Energy-Optimized Pharmacophore Coupled Virtual Screening in the Discovery of Quorum Sensing Inhibitors of LasR Protein of Pseudomonas aeruginosa
... the high-throughput virtual screening, pharmacophore screening, and molecular docking method recognized seven molecules as potential ...further drug designing and discovery against ...
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High-throughput virtual screening with e-pharmacophore and molecular simulations study in the designing of pancreatic lipase inhibitors
... conformational changes in both the protein and ligand. Changes in the confirmations of the molecules were due to the low fitness in the binding pocket, and even the hydroxyl group of Ser152 residue changed its ...
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Identification of Mannich Base as a Novel Inhibitor of Mycobacterium Tuberculosis Isocitrate by High-Throughput Screening
... public health. And this once optimism was relent- lessly pulverized. Intense investigations on ICL in- hibitor have revealed variety of drug leads promising to proceed into next stage[8]. Many have put on a ...
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