HIV-long terminal repeat
NF-κB cis-Acting Motifs of the Human Immunodeficiency Virus (HIV) Long Terminal Repeat Regulate HIV Transcription in Human Macrophages
... the HIV p24 levels gener- ated in the culture supernatants of THP1 cells infected with HXB- ⌬ B at different days following HIV infection ...ulating HIV replication, we first attempted to inhibit ...
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Effect of the Internal Promoter on Insertional Gene Activation by Lentiviral Vectors with an Intact HIV Long Terminal Repeat
... We have identified expression from the 5 ⬘ LTR, followed by splicing to an adjacent gene, as the main mechanism of insertional gene activation by lentiviral vectors in the Bcl-15 cell assay. However, transcription from ...
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Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKCα and PKCθ
... eradicating HIV from infected ...reactivate HIV from latency in a protein kinase C (PKC)-dependent manner; however, it is unknown which specific PKC isoforms are required for this ...induce HIV ...
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Methylation as a modulator of expression of human immunodeficiency virus.
... 1253 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest When Vero or murine cells were stably transfected with the human immunodeficiency virus HIV long terminal repeat LT[r] ...
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Kaposi's Sarcoma-Associated Herpesvirus ORF45 Mediates Transcriptional Activation of the HIV-1 Long Terminal Repeat via RSK2
... stimulates HIV-1 reactivation in coinfection experiments, and several studies indicate that HIV-1 and KSHV may target similar populations of cells in vivo, suggesting that this interplay is biologically ...
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5' long terminal repeat (LTR) selective methylation of latently infected HIV 1 provirus that is demethylated by reactivation signals
... Nevertheless, our results demonstrate that in the setting of full reactivation of viral gene expression by TNF- α stimu- lation, the provirus LTR showed only a partial demethyla- tion at scattered sites (Fig. 4). This ...
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Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.
... to HIV-1 or heterologous genes driven by the HIV-1 LTR, since other retroviral promoters which are not Tat responsive ...the HIV-1 LTR and requires sequences within the Sp1 motifs of the LTR (Table ...
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Adeno-associated virus Rep protein inhibits human immunodeficiency virus type 1 production in human cells.
... Constructs containing the AAV2 rep gene pHIVrep or a CAT gene pBennCAT expressed from the 5' HIV-1 long terminal repeat were inducible for Rep78 and Rep68 or CAT expression, respectively[r] ...
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Bovine leukemia virus long terminal repeat variability: identification of single nucleotide polymorphisms in regulatory sequences
... bp long sequence present at the 3′ end of the R region, which contributes to the enhancement of viral gene expression ...in HIV-1-infected cells, progesterone and estradiol regulate HIV-1 replication ...
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Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins.
... By assaying each mutant protein separately on the HTLV-I long terminal repeat LTR and the human immunodeficiency virus type 1 HIV-1 LTR in parallel, we were able to identify regions of T[r] ...
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Grossly Defective nef Gene Sequences in a Human Immunodeficiency Virus Type 1-Seropositive Long-Term Nonprogressor
... measure HIV-1 RNA in the peripheral mononuclear cells obtained from this subject have invariably ...the HIV-1 quasispecies infecting this patient by PCR amplification of two proviral regions, the 5 * ...
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Mycobacterium tuberculosis enhances human immunodeficiency virus 1 replication by transcriptional activation at the long terminal repeat
... three HIV+ ...of HIV-1. Mononuclear phagocyte cell lines U937 and THP-1 infected with HIV-1JR-CSF, in vitro and stimulated with live ...the HIV-1 long terminal repeat with ...
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Inhibition of Replication of Reactivated Human Immunodeficiency Virus Type 1 (HIV-1) in Latently Infected U1 Cells Transduced with an HIV-1 Long Terminal Repeat-Driven PKR cDNA Construct
... inhibiting HIV-1 replication utilized in this laboratory has been to employ the interferon (IFN)-associated antiviral defense ...viruses, HIV-1, and papillomavirus ...including HIV-1, have developed ...
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Transcriptional Targeting of Lentiviral Vectors by Long Terminal Repeat Enhancer Replacement
... their long-term repopulation and differentiation ...viral long terminal repeat (LTR) enhancer with cell lineage-specific, genomic control ...the HIV type 1 (HIV-1) ...
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Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat.
... Chicken ovalbumin upstream region promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type I long terminal repeat.. Regulation of HIV-[r] ...
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Functional properties of the HIV 1 long terminal repeat containing single nucleotide polymorphisms in Sp site III and CCAAT/enhancer binding protein site I
... of HIV-1-susceptible ...full-length HIV-1 LAI virus has the ability to infect all three cell line models used in this ...different HIV-1 backbones were used to infect the HPCs, monocytes, and T ...
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Macrophage signaling in HIV 1 infection
... of HIV-1 proteins (Nef, Tat, Vpr, and gp120) in modulating macrophage signaling has been recently ...structural HIV- 1 proteins interact with signaling pathways in infected ...of HIV-1 infected ...
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Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function.
... The NFKB binding sites in the human immunodeficiency virus type 1 long terminal repeat are not required for virus infectivity.. HIV-l Tat protein trails-activates transcription in vitro.[r] ...
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Variable role of the long terminal repeat Sp1-binding sites in human immunodeficiency virus replication in T lymphocytes.
... 1414 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The long terminal repeat LTR of the human immunodeficiency virus HIV contains three binding sites for the transcrip[r] ...
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Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
... two HIV proviruses, one lacking Tat’s ATG initiation codon, and the other containing Tat’s H13L mutation which weakens its interaction with P-TEFb [58, ...[71]. Long-term treatment of U1 cells with 10 nM of ...
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