human Islet Amyloid Polypeptide
Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide
... ABSTRACT. Amyloid aggregation of human islet amyloid polypeptide (IAPP) is a hallmark of type 2 diabetes (T2D), a metabolic disease and a global ...of amyloid-β (associated with ...
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Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein
... Human islet amyloid polypeptide (IAPP) and alpha synuclein (αS) are two major classes of amyloid proteins serving both functional and pathogenic roles in ...and amyloid fibrils ...
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Profiling the serum protein corona of fibrillar human islet amyloid polypeptide
... in amyloid coronae identified by either CC (AF) or QCM (AE) methods, structural information available in the order of whole sequences, the sequence homologs, or sub-sequences was obtained by searching the protein ...
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Autophagy defends pancreatic β cells from human islet amyloid polypeptide induced toxicity
... form amyloid fibrils, we used thioflavin S, a dye that binds to amyloid fibrils but not to soluble monomers (21), to investigate the interaction between p62 and insoluble IAPP fibrils within the cytosolic ...
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Amyloid Formation in Response to β Cell Stress Occurs In Vitro, but Not In Vivo, in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide
... Therefore, transgenic mice (over)expressing the human IAPP gene, might provide a useful model for studying the mechanisms leading to amyloid deposition in the islets and the possible rol[r] ...
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Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus
... Abstract: Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted with insulin from insulin-secreting pancreatic ...pancreatic amyloid deposits ...
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Mechanical Deformation Mechanisms and Properties of Prion Fibrils Probed by Atomistic Simulations
... of amyloid fibrils have been probed by a force spectroscopy based on optical tweezer or AFM, which allows for characterizing the mechanical behavior of protein materials in response to a force ...of human ...
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β Cell–specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity
... mice, islet p62 levels were markedly increased com- pared with WT (21, 39) (Figure 6, A and C), and p62 accumulation was evident as immunoreactive inclu- sions in β cells (Figure ...for human calpastatin ...
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Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo
... different human diseases, including Huntington’s disease, Parkin- son’s disease (PD), Alzheimer’s disease (AD) and ...beta amyloid in AD pa- ...into amyloid fibrils in pancreatic islets, eventually ...
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Effects of Free Fatty Acid on Polymerization of Islet Amyloid Polypeptide (IAPP) In Vitro and on Amyloid Fibril Formation in Cultivated Isolated Islets of Transgenic Mice Overexpressing Human IAPP
... Because amyloid fibril formation is a nucleation- dependent process, the very initial fibril formation is important to study to understand the develop- ment of amyloid ...
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Islet Amyloid Development in a Mouse Strain Lacking Endogenous Islet Amyloid Polypeptide (IAPP) but Expressing Human IAPP
... develop islet amyloid at any age, not even when crossed into an ob/ob mouse strain or made insulin-resistant by treatment with cor- ticosteroid ...some islet amyloid deposits appeared af- ter ...
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IL 1 produced and released endogenously within human islets inhibits beta cell function
... by human islets, and IRAP prevents both the inhibitory effects of TNF 1 LPS 1 IFN- g on insulin secretion and the stimulatory effects on iNOS expression and nitric ox- ide ...by human islet ...
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Gelsolin related amyloidosis Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin
... neuropathy. Amyloid fibrils were isolated from the kidney and heart of a patient with Finnish ...the amyloid proteins were fractionated by gel filtration and purified ...
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Characterisation, monitoring and treatment of systemic amyloidosis
... Twenty six cases o f systemic amyloidosis associated with Castleman’s disease have been reported previously. Seventeen o f these had confirmed reactive systemic, AA, amyloidosis (Table 6.2)^"^®’ Two were confirmed as ...
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Profile of gantenerumab and its potential in the treatment of Alzheimer's disease
... extracellular amyloid plaques composed largely of amyloid-beta peptide (A β ) and neu- rofibrillary tangles (NFTs), which are intracellular aggregates of hyperphosphorylated tau ...
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Evidence of a developmental origin for β cell heterogeneity using a dual lineage tracing technology
... Diabetes is characterized by inadequate functional pancreatic β -cells, which are required for the maintenance of normal blood- glucose levels (Ackermann and Gannon, 2007). Although β -cells are typically regarded as a ...
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Processing of Alzheimer's amyloid precursor protein in cultured cells
... increase in APP secretion. There is no increase in either APP695 protein or mRNA. There is, however an increase in APP770 mRNA, and a large increase in APP751 mRNA. This indicates that the up-regulation of APP production ...
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Islet cell transplantation for the treatment of type 1 diabetes: recent advances and future challenges
... successful islet isolation and ...the islet mass transplanted does not unequivocally correlate with islet graft ...for islet transplantation and hence allocation rules (pancreas for whole ...
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The autophagy related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
... analyzed with NIH Image version 1.63 (http://rsb.info.nih.gov/nih-image/) to determine the percent area of the neuropil occupied by MAP-2–immu- noreactive dendrites or synaptophysin-immunoreactive presynaptic termi- ...
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Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-<em>scid IL2rγ<sup>null</sup></em> mice treated with alogliptin
... One day post-transplant, diabetic mice that received islets from a single donor were randomized into two groups of five mice each and treated daily by oral gavage with 30 mg/kg/day alogliptin (provided by Takeda ...
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