human telomerase reverse transcriptase promoter
Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... of kidney cancer, reporting a positive rate of 78.9% in RCC tumor tissues and 0% in adjacent tissues. These results iden- tify hTERT expression as a specific characteristic of RCC cells, a finding consistent with the ...
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Promoter trapping method: transcription factor purification using human telomerase reverse transcriptase promoter
... (FT) has a similar pattern with similar intensity as the NE, indicative of the low abundance of promoter specific proteins involved in regulating a single promoter. The washes were also collected (data not ...
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
... the promoter and exon 1 regions are unmethylated ...the human gene promoters contain CpG islands, and there- fore DNA methylation has been thought to play an import- ant role in gene expression [128, ...
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Diverse regulatory manners of human telomerase reverse transcriptase
... hTERT promoter re- gion during telomerase ...hTERT promoter without affecting that of the WT pro- moter, indicating that GABPA is the hTERT-regulating ETS factor that acts in a mutation-specific ...
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Alternative splicing and extra-telomeric role of telomerase reverse transcriptase isoforms in human embryonic stem cells
... the promoter region. HSP90 (whose involvement is important for telomerase DNA binding and association with hTERC [113], [123, 124] was found to interact with the hTERT promoter in immortalized and ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... recurrence group. DNA methylation is one of the mecha- nisms that can instigate gene silencing in the process of carcinogenesis, especially in tumor suppressor genes [35]. Expression of hTERT still remains as one of the ...
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Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma
... of human gen- ome with important regulatory effects on the gene expres- sion in cancer ...the promoter region of telomerase reverse transcriptase (TERT) gene in about 85% of ...
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Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites
... High-risk human papillomaviruses (HPVs) immortalize keratinocytes by disrupting the retinoblastoma protein (Rb)/p16 pathway and activating ...induces telomerase activity in human ...activates ...
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Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... hTERT promoter by the upstream stimulatory factor (USF) in tumor cells ...in human sarcomas, and these results may suggest that p38 MAPK plays a role in ...
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Original Article The functional TERT MNS16A polymorphic tandem repeat minisatellite contributes to gliomas development
... Abstract: Background: MNS16A, located on chromosome 5p15.33 downstream of the human telomerase reverse transcriptase (hTERT) gene, was demonstrated to have some promoter activity and ...
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Photoactivatable RNAi for cancer gene therapy triggered by near-infrared-irradiated single-walled carbon nanotubes
... targeting human telomerase reverse transcriptase through RNAi, with the gene-knockdown activity capable of being switched off by extinguishing the ...in human malignant ...
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Original Article Screening and identification of antisense accessible sites of the human telomerase reverse transcriptase gene in prostate cancer cell lines
... Human prostate cancer cell lines, androgen- independent PC-3 cells [21] and DU145 cells were obtained from the American Type Culture Collection and maintained in RPMI 1640 medi- um for PC-3 cells or DMEM for DU145 ...
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Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis
... TERT promoter muta- tions were more frequent in aggressive histological types of thyroid ...TERT promoter mutations seemed to coexist with BRAF mutation, which contributed to more aggressive tumor and worse ...
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Macrophage derived interleukin 1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro
... (Peprotech). Human microvascular endothelial cells hMEC-1 [20], obtained from ATCC, were grown in endothelial basal medium (Lonza, USA) with 10% iron- supplemented donor calf serum, 1 μg/ml hydrocortisone (Sigma), ...
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Post-transcriptional regulation of telomerase reverse transcriptase (TERT) in human embryonic stem cells cultured under varying oxygen microenvironments
... of telomerase in human embryonic stem cell potency and ...in telomerase reverse transcriptase (TERT) expression, localization, and ...in telomerase subunit expression and its ...
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Original Article TERT rs2736098 polymorphism and bladder cancer risk: a meta-analysis
... tein polymerase, involved in DNA telomere elon- gation and plays an essential role in mainte- nance of telomere DNA length [9, 10]. Telomeres are special structures at the end of eukaryotic chromosomes that help to ...
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Original Article MicroRNA-138 suppresses cell proliferation of human malignant melanoma cells by targeting hTERT
... colorectal cancer migration and invasion in vitro and in vivo [29]. In ovarian cancer, miR- 138 can suppress cell invasion and metastasis by targeting SRY-box 4 (SOX4) and hypoxia inducible factor 1, alpha subunit ...
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Treatment of diabetes mellitus-induced erectile dysfunction using endothelial progenitor cells genetically modified with human telomerase reverse transcriptase
... The efficacy of treatments for diabetes mellitus-induced erectile dysfunction (DMED) is quite poor, and stem cell therapy is emerging as a useful method. In this study, we used endothelial progenitor cells (EPCs) ...
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Telomerase reverse transcriptase gene amplification in hematological malignancies
... that telomerase activity is not required for the initiation of AML and B cell neoplasm, but it is required for their ...enhanced telomerase activity was linked to disease progression, chemotherapy ...
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Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment
... with telomerase mutations are smokers and that current and former smokers have shorter telomeres than age-matched controls [7, ...a telomerase mutation may present as a person aged ,50 years with ...
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