hypoxia inducible factor-1α
Original Article Effect of hypoxia inducible factor 1α on the epithelial-mesenchymal transition of human prostate carcinoma cell and its invasion
... Abstract: Hypoxia inducible factor 1α (HIF-1α) is one important factor for transducing signal and inducing hypoxia ef- ...under hypoxia condition, for observing the ...
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Original Article Roles of heat shock protein 70 toward hypoxia-inducible factor 1α (HIF-1α) blockade in newborn rats with hypoxia-induced pulmonary hypertension
... that hypoxia inducible factor 1α (HIF-1α) is a key transcription factor of hypoxia [2], serving important roles in the pathogenesis of HPH ...
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Involvement of human chorionic gonadotropin in regulating vasculogenic mimicry and hypoxia-inducible factor-1α expression in ovarian cancer cells
... hCG, hypoxia-inducible factor-1α (HIF-1α), and the endothelial cell markers CD31, VEGF, and factor VIII were detected by reverse transcription polymerase chain reaction and ...
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Hypoxia-inducible factor-1α gene polymorphisms and cancer risk: a meta-analysis
... Intratumoral hypoxia is a hallmark of solid cancer ...[4]. Hypoxia-inducible factor -1 (HIF-1) is a key transcription factor that regulates cellular response to hypoxia ...tion ...
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Original Article Acute exposure to hypobaric hypoxia upregulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor
... Abstract: Hypoxia is a stress factor frequently encountered during flight and a common cause of tissue and cell injury experienced by in-flight ...of hypoxia on the body can vary depending on the ...
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Hypoxia inducible factor 1α regulates β cell function in mouse and human islets
... Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1α protein are tightly regulated, recent ...
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Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites
... Figure 1. Enrichment of HIF1α (hypoxia-inducible factor 1α) and glycolytic enzymes at atheroprone sites. The expression of HIF1α and several of its target genes was quantified at low wall ...
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Original Article 14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/ Akt/NF-кB signal transduction pathway
... of hypoxia-inducible factor-1α (HIF-1α), which is induced by hypoxia and a crucial factor for induction of tumor ...to hypoxia in our unpublished data as ...to ...
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Prognostic Value of Hypoxia-Inducible Factor 1α in Solid Malignancies: A Meta-Analysis
... Abstract: Numerous studies have reported the prognostic role of Hypoxia-Inducible Factor 1α （ HIF-1α ） and solid malignancies, but the data of different reports remains controversial. ...
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Original Article High altitude increases the expression of hypoxia-inducible factor 1α and inducible nitric oxide synthase with intest-inal mucosal barrier failure in rats
... hypobaric hypoxia related to the failure of intestinal mucosal ...of hypoxia-inducible factor 1α (HIF-1α), inducible nitric oxide synthase (iNOS) and morphological changes ...
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The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
... to hypoxia is primarily regulated by the hypoxia-inducible factors ...under hypoxia is mainly controlled by the oxygen-sensing HIF prolyl 4-hydroxylases (EGLNs, also known as ...
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Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor
... HCV gene expression stabilizes HIF-1 ␣ . In most of the HCC tumors associated with HCV, the presence of viral RNA has been demonstrated, suggesting a possible role of HCV in the maintenance of liver neoplasia (14). ...
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Hypoxia inducible factor 1α gene (HIF-1α) splice variants: potential prognostic biomarkers in breast cancer
... Primers and probes sets for HIF-1 a variants were tested using RT-qPCR on the HEK293 RNA and specific stan- dard plasmids. Primer concentration optimisation assays were carried out to determine the optimal concentra- ...
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Association of the hypoxia-inducible factor-1α (HIF-1α) gene polymorphisms with prognosis in ovarian clear cell carcinoma
... Genotyping of HIF-1α single-nucleotide polymorphism Samples were recruited from the formalin-fixed, paraffin embedded surgical specimens of OCCCs. DNA was ex- tracted using the Gentra Puregene Tissue Kit (Qiagen, ...
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Original Article Specific silencing of hypoxia inducible factor-1α, hypoxia inducible factor-2α and hypoxia inducible factor-1β by small interference RNA reduces the expression of vascular endothelial growth factor in BGC-823 gastric cancer cells under hypoxia
... Gastric cancer BGC-823 cells (Cell Bank, Chin- ese Academy of Sciences, Shanghai, China) were cultivated in RPMI-1640 media containing 10% fetal bovine serum (FBS) under 37°C and 5% CO 2 . The medium was refreshed every ...
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Herpesvirus entry mediator regulates hypoxia inducible factor–1α and erythropoiesis in mice
... Recent studies have provided compelling evidence that various factors other than oxygen concentration also promote HIF activity, including inflammatory stimuli, cytokines, hormones, and growth factors (10, 11). In ...
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Expression of relative-protein of hypoxia-inducible factor-1α in vasculogenesis of mouse embryo
... Background: Physiological vasculogenesis in embryonic tissues share some important features with pathological neoangiogenesis in tumors. Linearly Patterned Programmed Cell Necrosis (LPPCN) and Vasculogenic Mimicry (VM) ...
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Science review: Redox and oxygen sensitive transcription factors in the regulation of oxidant mediated lung injury: role for hypoxia inducible factor 1α
... growth factor (VEGF), glycolytic enzymes and glucose transporters, as well as cytokines and other inflammatory mediators ...by hypoxia-inducible factor ...
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Enzyme-Linked Immunosorbent Assay for Pharmacological Studies Targeting Hypoxia-Inducible Factor 1α
... The threshold of sensitivity of this method defined as twofold the background of the assay was 4 ng. HeLa cells were incubated in standard hypoxic conditions for different times up to four hours and HIF-1 ␣ protein was ...
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Original Article Hypoxia-inducible factor 1α (HIF-1α) mediates the epithelial-mesenchymal transition in benign prostatic hyperplasia
... Abstract: Background: Epithelial-mesenchymal transition (EMT) based cancer cell invasion and metastasis has been thoroughly studied in prostate cancer. It was well known that EMT markers which have been found in benign ...
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