Immune infiltrate
Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients
... Importantly, the presence of CD20 + B cells correlates with improved OS in our cohorts of chemotherapy-naive patients with HGSC, which is line with previous obser- vations from other oncological settings [13, 14, 38–41]. ...
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Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies
... There are two major technologies to retrieve information on the immune infiltrate. The first technique consists in performing immunophenotyping of infiltrating leukocytes either in situ (by ...
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High OX-40 expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer
... cell immune infiltrate, we did not find any significant im- provement in survival, indicating that OX-40 is a stronger prognostic driver than ICOS positivity ...dependent immune re- sponses in vivo, ...
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Pathobiology of the 129:Stat1 −/− mouse model of human age related ER positive breast cancer with an immune infiltrate excluded phenotype
... cluded infiltrate” mononuclear density [39], we postulated that the Stat1-null tumor cells might mediate the host im- mune response through release of cytokines and other growth ...
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Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation
... cell-mediated immune responses, which may be responsible for the placental damage leading to ...placental immune response following an experimental inoculation of pregnant cattle with ...The immune ...
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Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin 1 and high tenascin C and their combination as significant prognostic markers in non small cell lung cancer
... of immune infiltrate, assessing markers of cancer-associated fibroblasts, caveolin-1 and tenascin-C, and correlating with clinicopathological details, as well as markers of disease progression such as ...
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Data integration from pathology slides for quantitative imaging of multiple cell types within the tumor immune cell infiltrate
... To quantify TILs within and surrounding nests of tumor cells in regions of invasive breast carcinoma, we con- ducted IHC staining with 5 antibodies in a cohort of 81 cases of HER2+ invasive breast carcinoma. Slide-1 was ...
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Suppressing miR 21 activity in tumor associated macrophages promotes an antitumor immune response
... tumor immune infiltrate, and in particular in macrophages, was responsible for promoting tumor ...antitumoral immune response characterized by a macrophage- mediated improvement of cytotoxic T-cell ...
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Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery
... anti-tumor immune response differences dependent on background ...tumor- immune microenvironment evolves during the course of tumor development in CT-26, MC38 and 4 T1, three of the most commonly used ...
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Immune characterization of breast cancer metastases: prognostic implications
... tumor immune infiltrate may be different across metastatic ...permissive immune microenvironment for tumor ...toxic immune activity in skin tissue through different immunosuppressive ...
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Current landscape and future directions of biomarkers for predicting responses to immune checkpoint inhibitors
... Abstract: Immune checkpoint inhibitors (ICIs), represented by anti-CTLA-4 or anti-PD-1/ anti-PD-L1 pathway antibodies, have led to a revolution in cancer treatment ...from immune surveillance, the ...
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Taylor_unc_0153D_14758.pdf
... local immune response, can both shape and drive tumor growth ...growth. Immune cells contribute to tumor progression through the production of soluble factors that regulate cell proliferation, migration, ...
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Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases
... anti-tumor immune responses and facilitate me- tastasis ...innate immune cell populations, such as TAMs, MDSCs or TANs, can play complex roles during cancer initiation and progression to ...in ...
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Immune landscapes associated with different glioblastoma molecular subtypes
... GBM immune landscape, we used several cores across all the sections obtained for each ...the immune infiltrate across differ- ent cores in the same ...each immune marker among cores, then ...
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Original Article A clinicopathological study of TRAIL expression in halo nevi
... sis [19]. Therefore it may behave as a pro- or anti-apoptotic molecule depending on the tis- sue. Some studies suggest that it is related to a more aggressive phenotype such as in mela- noma [25]; while others have ...
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Role of Immunohistochemistry in the Early Detection of Gastrointestinal Lymphomas with Special Reference to Lymphoplasmacytic Infiltrate.
... original immune enzyme bridge method using enzyme specific antibody became rapidly superseded by the improved technique using a soluble peroxidase-antiperoxidase complex ...
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PubMedCentral-PMC5669567.pdf
... esize that approaches that target Tregs would enhance the antitu- mor immune response. To deplete Tregs, we made use of mice in which the diphtheria toxin (DT) receptor had been knocked in to the FoxP3 locus ...
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Infiltrate the Vault: Security Analysis and Decryption of Lion Full Disk Encryption
... The EncryptedRoot.plist.wipekey file is en- crypted using AES-XTS (details later) with an all-zeros tweak key, but the encryption key is easily available in the header (first block) of t[r] ...
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T Cells Infiltrate the Brain in Murine and Human Transmissible Spongiform Encephalopathies
... Yet, immune responses are reproducibly gener- ated against other “self antigens” when the self protein or one of its peptide fragments is inoculated with adjuvants or during ...example, immune responses to ...
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A Quantitative Evaluation Of Epithelium And Inflammatory Infiltrate Of Lichen Planus And Lichenoid Reactions
... Results: Positive correlation was seen between epithelial and inflammatory band thickness in cases of lichenoid reactions and a negative correlation in cases of lichen planus. Conclusion: The study suggests that the ...
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