Inner Ear Development
CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development
... in inner ear ...developing ear and undergo complex changes in expression patterns throughout embryogenesis ...the ear and surrounding areas, suggesting cross-regulatory mechanisms that control ...
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From placode to polarization: new tunes in inner ear development
... the inner ear is one of the most remarkable events in vertebrate ...cellular development is still extremely ...of inner ear development, including formation of the otic placode ...
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Discovering Novel Hearing Loss Genes: Roles For Esrp1 And Gas2 In Inner Ear Development And Auditory Function
... Our analysis of Esrp1 mutant cochlea revealed a number of differentially spliced transcripts with unknown significance to inner ear development. We were able to establish that aberrant splicing of ...
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Grhl1 deficiency affects inner ear development in zebrafish
... barrier development and post-wounding barrier repair via regulation of junction protein expression and to epithelial adhesion, which is essential to organ development (Hama) (Forge et ...integrated ...
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Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice
... To directly test the functional importance of specific candidate enhancers in vivo, we used CRISPR/Cas9 genome editing to make deletions of the phylogenetically conserved eDlx#23 and hs1642 elements and also a deletion of ...
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Analysis of Netrin 1 receptors during inner ear development
... Ntn1-/- inner ear development and the adhesion mediating Ntn1 receptors, Neo1 (Srinivasan et ...on inner ear ...in inner ear remains to be ...in inner ear ...
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Mouse models to study inner ear development and hereditary hearing loss
... affect inner ear development as ...1994). Inner ears of homozygous Dmm embryos had less collagen fibrils and pre- sented irregular cytodifferentiation of chondrocytes in the extra- cellular ...
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Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development
... mammalian inner ear is a sensory organ with dual roles in sound and motion ...the inner ear to auditory and vestibular components occurs early in embryonic development, allowing each of ...
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Pocket proteins and cell cycle regulation in inner ear development
... Among the group of E2F family members that interact with the pocket proteins (Figure 3), E2F1, E2F2 and E2F3a are consid- ered potent transcriptional activators, binding according to our current understanding, ...
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Building an artificial stem cell niche: prerequisites for future 3D-formation of inner ear structures-toward 3D inner ear biotechnology
... for inner ear development (Fritzsch et ...of inner ear progenitor ...Alternatively, inner ear pro- genitors can be generated in vitro, from other stem cell populations, ...
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Sculpting the labyrinth: Morphogenesis of the developing inner ear.
... The inner ear, as a highly 3D sophisticated organ that under- goes extensive tissue remodelling during development, constitutes an excellent model to tackle the question of how biomechan- ics, tissue ...
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Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
... mutant inner ears are usually missing the endolymphatic duct (Table 1, n=18/19), with an enlarged membranous labyrinth ...the inner ears are missing the common crus ...III inner ears, the anterior ...
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Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear
... on inner ear tissues? One possibility is that it travels from the midline and acts on otic tissues ...ventral inner ear ...the inner ear have been shown to be regulated by SHH ...
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Suppression of neural fate and control of inner ear morphogenesis by Tbx1
... and inner ear sensory organ ...affects inner ear growth and morphogenesis in a global ...of inner ear development using tissue- specific gene inactivation strategies are ...
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Shaping sound in space: the regulation of inner ear patterning
... during inner ear ...otocyst development, gradients of sonic hedgehog (Shh) target genes are observed along the DV axis (gray ...dorsal inner ear ...the inner ear during ...
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Mobile Phone Antenna with Reduced Radiation into Inner Ear
... The effect of radiation in the inner ear has two folds: the effect on the neural tissues (hearing) and the effect on the filling liquid (balance). The radiation devices must be compliant to the SAR standard ...
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Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
... tors ascribed to specific endocytic pathways were used to investigate the endocytosis pathway of PLGA NPs. Finally, after being internalized, the endocytosed cargos were trans- ferred to various cellular organelles, ...
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Notch signaling in the development of the inner ear
... However, ear development ap pears entirely normal in mice with a knockout mutation of the Lfrig gene (55), and we see no abnormalities in ears overexpressing Lj&ig as a result of infection with ...
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Single cell analysis of the inner ear sensory organs
... the inner ear, demonstrating the cells that may be analyzed on a single cell ...of inner hair cells and three rows of outer hair cells, the sensory cells of the inner ear, and ...
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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
... of inner ear hair cells and the orientation of their stereocilia bundles (Barald and Kelley, ...eye development in Drosophila, where Notch signaling specifies the R4 photoreceptor cell fate (McNeill, ...
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