insulin receptor substrate 1 or 2
Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... Genomic DNA samples were extracted from peripheral blood lymphocytes of patients using TIANamp Blood DNA kits (Tiangen Biotech CO., LTD. Beijing, China). DNA concentration and quality were assessed using absorbance ...
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L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... for 1 week to stabilize their metabolic ...into 2 groups; a control group (n = 7, not treated) and L-Cit group (n = 7, administrated 2 g/kg/ day L-Cit by free access to ...
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... of insulin receptor sub- strate (IRS) members, a family of structurally related adaptor molecules which have classically been identified as key signalling intermediates of the IR and IGF-IR ...kinase ...
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Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
... Type 2 diabetes affects ...(1, 2). Most disease models point to obesity as an important cause of type 2 diabetes, because of its association with skeletal muscle insulin resistance and ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... This study included 583 patients with MDD and 564 healthy controls. Demographic characteristics of our parti- cipants are presented in Table S1. As shown in Table S1, female participants were about twice as likely as ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... for 2 hours at 65°C with cDNA probes for mouse osteoclast differ- entiation factor (RANKL/ODF), which was labeled using a multirandom primer oligonucleotide labeling kit (Boehringer, Mannheim, Germany) and [ 32 ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... IRS- 1 that were used were the PH domain (residues 1–155), the PH-PTB domains (residues 1–578) and the PH-PTB- pre-C-terminal domains (residues ...lane 2) or omit- ted (Figure 1C lane 3), no ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... type 2 diabetic pa- tients and ...with insulin resistance, salt sensitivity and non-dipper hypertension ...were 1) to investigate the insulin receptor substrate-1 ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... vivo substrate for Pim protein kinases, MEF cells derived from wild type (WT) and triple knockout of Pim1, Pim2 and Pim3 (TKO) FVB mice were ...lane 1 and ...Pim1, 2 and 3 by siRNAs in non-small cell ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... random-fed insulin and blood glucose levels were starved overnight, anesthetized in the morning by intraperitoneal injection with Avertin ...sion 1. Approximately 1 µg of total RNA was isolated from ...
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Expression and function of the insulin receptor substrate proteins in cancer
... between the two family members, and IRS-1 and IRS-2 have been reported to activate common signaling path- ways including PI3K and the Erk1/2 MAPK kinases in a variety of cancer model systems ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... In situ hybridization and histochemistry. Frozen 12-μm-thick sections from mouse brain that included the hypothalamus were cut in a cryostat at –20°C, and after thaw mounting onto gelatin-chrome alum-coated slides, these ...
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Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice
... Moreover, insulin and insulin-like growth factor cellular signaling were differen- tially altered in ovarian cells from women with PCOS, but after TZD treatment cell signaling was similar to cells from ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... AMPA receptor function is unlikely to be changed ...NMDA receptor activation is ...AMPA receptor function in ...AMPA receptor subunit GluR1 between genotypes ...NMDA receptor subunits ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... Generation of floxed allele of Irs2 and genotyping strategies for Irs2lox and Cre and ZEG transgenic mice. The murine Irs2 gene was cloned from a 129Sv mouse genomic PAC library. We cloned 2.8 kb of 5′ homology from the ...
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Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population
... reduced insulin sensitivity [10], as well as an increased susceptibility to type 2 DM [11] and CAD ...type 2 DM [14]. In humans, Gly1057Asp polymorphism in IRS-2 is caused by a SNP in the ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
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