interleukin-15
Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction
... Interleukin-15 (IL-15) is a cytokine that was discovered in- dependently by two groups in 1994 as an IL-2-like activity in the culture supernatants (SN) of two transformed cell lines. Its gene has ...
8
Interleukin-15 Is Critical in the Pathogenesis of Influenza A Virus-Induced Acute Lung Injury
... Interleukin-15 (IL-15) is a pleiotropic cytokine involved in both innate and adaptive immune responses (20, 36). IL-15 utilizes the  -chain of the IL-2 receptor (IL-2R) (CD122) and the common ...
9
Original Article Association between interleukin-15 polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population
... Abstract: Background: An association between interleukin-15 (IL-15) polymorphisms and the prevalence of rheu- matoid arthritis (RA) in Caucasians has been reported. We hypothesized that IL-15 ...
8
Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice
... Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector ...
8
Value of Interleukin-7 and Interleukin-15 as Predictors of Graft Versus Host Disease in Recipients of Allogeneic Bone Marrow Transplantation
... Background: Allogeneic hematopoietic stem cell transplantation is a curative therapy for a wide spectrum of hematological and non-hematological disorders. The development of post-transplant complications- notably GVHD, ...
19
Interleukin-15 Increases Effector Memory CD8+ T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
... Interleukin-15 (IL-15) in vitro treatment of peripheral blood mononuclear cells (PBMC) from human im- munodeficiency virus (HIV)-infected individuals specifically enhances the function and survival ...
9
Recombinant Porcine Reproductive and Respiratory Syndrome Virus Expressing Membrane-Bound Interleukin-15 as an Immunomodulatory Adjuvant Enhances NK and γδ T Cell Responses and Confers Heterologous Protection
... cytokine interleukin-15 (IL- 15) or IL-18 gene fused to a glycosylphosphatidylinositol (GPI) modification signal that can anchor the cytokines to the cell ...SUV-IL- 15-vaccinated pigs also had ...
19
Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region
... Interleukin-15 (IL-15) is a cytokine that utilizes the  and ␥ chains of the IL-2 receptor as well as its own private ␣ chain (IL-15R␣) in T and natural killer (NK) cells. IL-15 stimulates T- ...
12
Porcine Reproductive and Respiratory Syndrome Virus Induces Interleukin-15 through the NF-κB Signaling Pathway
... Porcine reproductive and respiratory syndrome virus (PRRSV) mainly infects macrophages/dendritic cells and modulates cyto- kine expression in these cells. Interleukin-15 (IL-15) is a pleiotropic ...
12
NK and NKT Cell-Independent Contribution of Interleukin-15 to Innate Protection against Mucosal Viral Infection
... Innate immunity plays a crucial role in the defense against viral infections (6, 7). This is especially true for mucosal sur- faces, where the vast majority of pathogens initiate infection (18). Indeed, as we and others ...
9
Development of Smallpox Vaccine Candidates with Integrated Interleukin-15 That Demonstrate Superior Immunogenicity, Efficacy, and Safety in Mice
... The potential use of variola virus, the etiological agent of smallpox, as a bioterror agent has heightened the interest in the reinitiation of smallpox vaccination. However, the currently licensed Dryvax vaccine, despite ...
10
Human Interleukin-15 Improves Engraftment of Human T Cells in NOD-SCID Mice
... Regarding the efficiency of engraftment of huPBLs into SCID/NOD-SCID mice, a wide variety of stimulators of hu- man hematopoiesis have also been tested in efforts to promote the engraftment of lymphocytes into ...
8
Transpresentation of interleukin‑15 by IL‑15/IL‑15Rα mRNA‑ engineered human dendritic cells boosts antitumoral natural killer cell activity
... already in remission for some years) was comparable to that of healthy donors, while for AML patient 3 who only recently was brought into remission after consolidation therapy overall less tumor killing was observed. For ...
11
Skeletal muscle interleukin 15 promotes CD8+ T-cell function and autoimmune myositis
... The H-2K b (NM_001001892) coding sequence (nt. 77- 1186) was cloned from the cDNA library of primary myotubes of C57BL/6J mice and then inserted into the EcoRI cloning site of lentiviral package plasmid pLKO ...
14
Original Article Expression and correlation of matrix metalloproteinase-7 and interleukin-15 in human osteoarthritis
... This study was approved by the hospital medi- cal ethics committees, and informed consent was obtained from all participants. Between October 2013 and December 2014, thirty patients with knee OA (13 males and 17 females; ...
7
Myxoma Virus Expressing Interleukin-15 Fails To Cause Lethal Myxomatosis in European Rabbits
... MYXV-IL-15-tdTr is attenuated in European rabbits. This animal study was approved by the Institutional Animal Care and Usage Committee (IACUC) at the University of Florida. MYXV pathogeneses in New Zealand White ...
6
Original Article Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling
... ies is low or absent but its expression is en- hanced by SMC in atherosclerosis [29, 30]. In vivo, PDGF-β forms a homodimer (PDGF-BB), which signals via its receptor PDGFR-β. Several studies in experimental models of ...
8
Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice
... treatments, total HBV-specific DNA and RNA in the liver were analyzed by quantitative real-time PCR. IFN-␣, IL-15, and the combination treatment exerted similar inhibitory effects on HBV replication (Fig. 1C). ...
12
Activation of antigen induced lymphocyte proliferation by interleukin 15 without the mitogenic effect of interleukin 2 that may induce human immunodeficiency virus 1 expression
... The in vitro activities of the newly identified cytokine IL-15 are similar to those of IL-2 (1). Like IL-2, IL-15 supports the growth of IL-2–dependent T cell lines and enhances prolifera- tive responses to ...
7
Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model
... Cytokines of the common γ -chain receptor family such as IL-15 are vital with respect to activating immune cells, sustaining healthy immune functions, and augmenting the anti-tumor activity of effector cells, ...
13