Intrinsically disordered proteins
Differential dehydration effects on globular proteins and intrinsically disordered proteins during film formation
... Globular proteins composed of different secondary structures and fold types were exam- ined by synchrotron radiation circular dichroism spectroscopy to determine the effects of dehydra- tion on their secondary ...
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Sequence and Structure Properties Uncover the Natural Classification of Protein Complexes Formed by Intrinsically Disordered Proteins via Mutual Synergistic Folding
... Intrinsically disordered proteins mediate crucial biological functions through their interactions with other ...interacting proteins are disordered, folding into a stable structure in ...
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DisBind: A database of classified functional binding sites in disordered and structured regions of intrinsically disordered proteins
... more proteins are shown to be partially or wholly unstructured or intrinsically disordered [1, ...These intrinsically disordered proteins (IDPs) or regions (IDRs) in a protein ...
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Experimental and computational analysis of the structure and dynamics of intrinsically disordered proteins
... Intrinsically disordered proteins (IDPs) are a biologically functional class of proteins that comprise ~30% of the eukaryotic proteome ...active disordered proteins illustrates ...
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Testing the transferability of a coarse grained model to intrinsically disordered proteins
... The intermediate-resolution coarse-grained protein model PLUM [T. Bereau and M. Deserno, J. Chem. Phys., 2009, 130, 235106] is used to simulate small systems of intrinsically disordered proteins ...
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Tardigrades Use Intrinsically Disordered Proteins to Survive.pdf
... tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation ...of disordered proteins involved in stress ...
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gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins
... His-tagged gH625-c-prune (2 mg) was immobilized on Ni-NTA resin (the capacity of the resin is 10 mg/mL of tagged protein). HeLa cells were resuspended in phosphate buffered saline (PBS) supplemented with 1% Triton X-100 ...
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Determining a substitution matrix for the alignment of disordered proteins
... The initial population contained a wide range of the PAM set of matrices which included the PAM10 to PAM500 set of matrices. Each matrix had every possible combination of the corresponding gap-opening score ranging from ...
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Ion mobility spectrometry-mass spectrometry of intrinsically unfolded proteins: trying to put order into disorder
... of proteins, however, do not adopt a well-defined native structure and therefore present an intriguing challenge in terms of structural elucidation [2, ...these intrinsically disordered ...
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Bovine Viral Diarrhea Virus Core Is an Intrinsically Disordered Protein That Binds RNA
... of intrinsically disordered ...unstructured proteins have a large propor- tion of solvent-exposed residues and are therefore highly sus- ceptible to trace amounts of ...be disordered in its ...
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Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein
... many proteins, correct folding to a specific 3D structure is essential for their function inside the cell; once folded, some of these have the appropriate shape and accessible chemical groups to interact ...
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Determining a new alignment scoring matrix for disordered proteins
... Intrinsically disordered proteins (IDPs) are polypeptide sequences that do not form a rigid three dimensional structure when isolated in the cytosol of the ...
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Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence
... It has been established that IDPs lack of that stable second and tertiary structure under physiological and in vitro conditions, due to its high flexibility and random coil con- formation [20]. The ability of a protein ...
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Folding factors and partners for the intrinsically disordered protein Micro Exon Gene 14 (MEG 14)
... The effect of the temperature on the conformation of MEG-14 (Fig. 3 a) was radically different from that gener- ally observed in soluble globular proteins (39,40). Instead of unfolding as the temperature is ...
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The Development Of Intrinsically Fluorescent Unnatural Amino Acids For In Vivo Incorporation Into Proteins
... Fluorescent Labeling Using Unnatural Amino Acids with Bioorthogonal Reactivity An alternative approach for protein labelling can be performed by site-specific incorporation of Uaas with “biorthogonal” handles into ...
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Identification of Publications on Disordered Proteins from PubMed
... to disordered proteins with 87% ...a disordered protein present in the abstract, discuss about the structure or experimental methods of the disordered protein and one of the criterion for ...
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Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity
... This view of the battle between the virus and the immune sys- tem is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred server shown in Fig. 5b. Here we can see that the ...
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Is the geodynamo process intrinsically unstable?
... Recent studies suggest that the Earth's magnetic ¢eld has fallen dramatically in magnitude and changed direction repeatedly since the last reversal 700 kyr ago (Langereis et al. 1997; Lund et al. 1998). These important ...
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NmeCas9 is an intrinsically high fidelity genome editing platform
... can, in some circumstances, enhance specificity [89]. In keeping with the generally lower enzymatic activity, a re- cent report found NmeCas9 to exhibit consistently lower cellular editing activity than the two type II-A ...
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Achieving precise mechanical control in intrinsically noisy systems
... in intrinsically noisy systems? Here, we develop a general theoretical framework that provides a way of achieving precise control in signal-dependent noisy ...
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