Jagged-1
Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1
... of jagged 1 in epidermis and dermis In developing skin, jagged 1 is detected both in the epidermis and dermis (see ...skin, jagged 1 is primarily expressed in the bulb of anagen ...
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Original Article Relation of JAGGED 1 and collagen type 1 alpha 1 polymorphisms with bone mineral density in Chinese postmenopausal women
... Another important candidate gene for predis- position to osteoporosis is the JAGGED 1 (JAG1) gene, which has been reported involved in bone formation. This gene encodes a cell surface protein called ...
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Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification
... Hair cells of the inner ear sensory organs originate from progenitor cells located at specific domains of the otic vesicle: the prosensory patches. Notch signalling is necessary for sensory development and loss of ...
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Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
... on Jagged-2 signalling ...of Jagged-2; siRNA knock down of this ligand resulted in abrogation of tDC inhibition of lymphocyte proliferation ...do Jagged-1 expressing MSC expand a Treg ...
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Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
... of Jagged-1, whereas overexpression of Jagged-1, in turn, promoted the expression of IL-6 that triggered the activation of ...6-induced Jagged-1 expression, strongly inhibited ...
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Original Article Jagged-1 attenuates LPS-induced apoptosis and ROS in rat intestinal epithelial cells
... μg/mL Jagged-1 protein ...of Jagged-1, Notch1, Hes1, and OLFM4 in colon tissues were detected by real-time quantitative PCR (qRT-PCR) and Western ...and Jagged-1, Notch1, Hes1, ...
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Jagged 1 is a β catenin target gene required for ectopic hair follicle formation in adult epidermis
... of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal ...
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Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing
... Notch 1–4 trans- membrane receptors, (b) two families of transmembrane ligands with numerous EGF repeats, Delta 1–3 and Jagged 1 and 2, and (c) three proteins modulating the ligand-re- ceptor ...
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Is there a role for Notch signalling in human breast cancer?
... Notch genes encode large transmembrane proteins that act as receptors for the Delta, Serrate, Lag-2 (DSL) family of ligands (Fig. 1a) [1]. There are four different Notch pro- teins in mammals and five known ...
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Jagged Notch signaling ensures dorsal skeletal identity in the vertebrate face
... that Jagged-Notch signaling ensures dorsal identity within the hyoid and mandibular components of the facial skeleton by repressing ventral ...in jagged 1b (jag1b) that results in dorsal expansion of ...
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Notch3 Jagged signaling controls the pool of undifferentiated airway progenitors
... Preferential Notch ligand-receptor binding depends on multiple factors, including biological context and cell type (D ’ Souza et al., 2008; Kopan and Ilagan, 2009). We reasoned that p63+ airway progenitors were a source ...
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miRNA 34b as a tumor suppressor in estrogen dependent growth of breast cancer cells
... and Jagged-1 (JAG1) in an ER+/wild-type p53 breast cancer cell line (MCF-7), as well as in ovarian and endometrial cells, but not in ER-negative or mutant p53 breast cancer cell lines (T47D, MBA-MB-361 and ...
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Cancer stem cells and oral cancer: insights into molecular mechanisms and therapeutic approaches
... ligands Jagged 1 (JAG1), JAG 2, and δ-like, accompanied by the proteolytic releases of the Notch intra-cellular domain (NICD), and activat- ing NICD down-stream target genes ...
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Caroli Disease Associated With Vein of Galen Malformation in a Male Child
... ligand Jagged 1 both in the development of cerebral arteriovenous malformations in general and in the formation of dilated intrahepatic bile ducts (eg, in Caroli ...
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Mib Jag1 Notch signalling regulates patterning and structural roles of the notochord by controlling cell fate decisions
... Movie 1 in the supplementary material) (Gamse et ...zebrafish jagged 1 homologues are expressed in spatially and temporally restricted patterns in the developing notochord, and their expression is ...
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BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation
... The Notch signalling pathway is an evolutionarily conserved mechanism that enables adjacent cells to adopt different fates (Artavanis-Tsakonas et al., 1995; Gridley, 1997; Robey, 1997; Weinmaster, 1997). Four isoforms of ...
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Thesis
... Winter dwindled them away as wonder turned to work, the ground firm in February, tools hard to hold with gloves,.. granite shard jagged in its hole, deep-rooted.[r] ...
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An Archaic Inscription from Attica
... The jagged break is near the middle of the stone and two letters that were visible earlier on Face A (05) have entirely disappeared. Both inscribed faces were covered with [r] ...
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Video resampling algorithm for simultaneous deinterlacing and image upscaling with reduced jagged edge artifacts
... proposed jagged edge correction (JEC) method is applied to the initially upscaled images to correct the stair-like artifacts (jagged edges) which are caused by ignoring any edge information in diagonal edge ...
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Search | Preprints
... Metastasis remains the major cause of cancer-related deaths [1]. To enable successful metastasis, cancer cells often engage a trans-differentiation program referred to as epithelial-mesenchymal transition (EMT) in ...
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