Lod score
A Quantitative Trait Locus Mixture Model That Avoids Spurious LOD Score Peaks
... (the LOD score). This approach can occasionally produce spurious LOD score peaks in regions of low genotype information ...spurious LOD score peaks is ...
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High-Resolution Genetic Mapping of Complex Traits from a Combined Analysis of F2 and Advanced Intercross Mice
... QTLRel uses a two-step procedure to fit the mixed model to the data: first, the model parameters are estimated as- suming that no markers have an effect on the phenotype (the null hypothesis); second, for a given marker, ...
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Biased Estimation of the Recombination Fraction Using Half-Sib Families and Informative Offspring
... the dam population. A comparison of the values of linkage parameters in practical scenarios is needed to evaluate the impact of using only informative offspring in the construction of a genetic map. Discrepancies in ...
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Overweight condition and waist circumference and a candidate gene within the 12q24 locus
... The results of the variance component analysis per- formed for the quantitative trait waist circumference in cm with the LOD score, P-value, empirical P-value, trait heritability and tra[r] ...
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Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
... Model-based LOD scores matched VC LOD scores in both peak location and general shape ...model-based LOD score did not provide a third peak between the two peaks that the VC LOD ...
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Mapping the gene causing X linked recessive idiopathic hypoparathyroidism to Xq26 Xq27 by linkage studies
... Idiopathic hypoparathyroidism has been reported to occur as an X-linked recessive disorder in two multigeneration kindreds. Affected individuals, who are males, suffer from infantile onset of epilepsy and hypocalcemia, ...
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Genetic factors in lipoprotein metabolism Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach
... cholesterol (lod 5.6), and chromosome 7 markers were linked to levels of total plasma triglycerides (lod 5.1) and free fatty acids (lod 5.6). Plasma apoAII levels were linked to the apoAII gene ...
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Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0
... Glycogen storage disease type 0 (GSD-0) is a rare form of fasting hypoglycemia presenting in infancy or early child- hood and accompanied by high blood ketones and low ala- nine and lactate concentrations. Although ...
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A Genome-Wide Scan for Linkage to Chromosomal Regions in 382 Sibling Pairs with Schizophrenia or Schizoaffective Disorder
... peak lod score of ...peak lod score exceeding criteria for suggestive linkage as suggested by Lander and Kruglyak (19) in the centromeric region of chromosome 2 near the marker D2S417 (102 cM ...
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Estimation of Genetic Recombination Frequency with the Help of Logarithm Of Odds (LOD) Method
... A large data sample is needed to determine a LOD score. In this type of statistical analysis, when the sample is big, the inferences will be better. This method can be applied on organisms like fruit, ...
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Quantitative Trait Locus Analysis Using Recombinant Inbred Intercrosses
... The probability of a perfect match of a permuted re- sponse vector is ⱖ0.05 for the CXB, whereas the prob- abilities for the AXB/BXA and BXD are much less than the stated 0.05 nominal level. This suggests that the ...
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A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases
... the LOD score ...KC- LOD score proposed by Kong and Cox ...maximum LOD with respect to the genetic ...MOD score analysis ...
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Disease Gene Mapping in General Pedigrees
... Non-parametric linkage analysis detects the chromosomal regions in which there is excess IBD sharing among cases in a pedigree. However, different pedigrees that contribute to a linkage signal might share different ...
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α cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
... disease gene. The remaining affected family members were characterized by having an abnormal electrocardio- gram, and most of them had a septal bulge in LVOT. Individual III-6 had an early onset of disease, presenting at ...
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A pharmacogenetic approach to blood pressure in Lyon hypertensive rats A chromosome 2 locus influences the response to a calcium antagonist
... chromosome 2 that specifically influences the systolic (peak LOD score 4.4) and diastolic (peak LOD score 4.1) blood pressure responses to administration of a dihydropyridine calcium ...
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Mapping the gene causing X linked recessive nephrolithiasis to Xp11 22 by linkage studies
... Linkage with the locus DXS255 was established with a peak LOD score = 5.91 at 3.6% recombination, thereby localizing the X-linked recessive nephrolithiasis gene to the pericentromeric re[r] ...
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LINKAGE STUDIES WITH NINE BLOOD-GROUP LOCI IN PIGS
... ever, this evidence for linkage was not confirmed by the lod score method; nor was there any significant evidence of linkage among the remaining 42 compari- sons of blood-gr[r] ...
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Genome wide search for breast cancer linkage in large Icelandic non BRCA1/2 families
... alleles or a polygenic model with risk variants of lower penetrance jointly affecting risk in miscellaneous combi- nations [6-8]. However, the gene most recently identi- fied, RAD51C [9], demonstrates that some ...
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Risk of adhesions formation following microsurgical monopolar laparoscopic ovarian drilling: a comparative study
... undergoing LOD [22], which represents a real limiting factor for ...of LOD highlights the importance of following microsurgical principles during reconstructive adnexal laparoscopic ...following LOD ...
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TopFed: TCGA tailored federated query processing and linking to LOD
... The aim behind the work presented in this paper was to develop the computational concepts - and devise a proto- type - that enable the exposure of TCGA as a distributed, semantically awa[r] ...
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