MAC, membrane attack complex of complement
Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement Proteins
... a complement evasion protein that can attenuate the activation of the classical, lectin, and alternative ...minal complement pathway. We identified the terminal complement regulator vitronectin (VN) ...
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Hepatitis C Virus Suppresses C9 Complement Synthesis and Impairs Membrane Attack Complex Function
... healthy volunteers. HCV sera or NHS as a control were incu- bated with a known titer of VSV (⬃100 PFU) in the presence of antibody to VSV G glycoprotein and with a fixed dilution (1: 20) of NHS or HCV patient sera (as a ...
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CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
... CryoEM. In order to obtain a sufficient proportion of intact pores on cryoEM grids, freshly purified solublized MAC (2.5 µl) was applied to glow-discharged holey carbon grids (Quantifoil R 1.2/1.3). Samples were ...
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Original Article Complement membrane attack complex is related with immune-mediated necrotizing myopathy
... cause membrane irreversible damage in some specific pathologi- cal ...the membrane, leading to internal flow of water, ions, and small molecules while mac- romolecules and proteins are incapable of ...
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Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice
... the complement system mediates secondary brain injury, which leads to increased infarct volumes, a pronounced inflammatory response, and a worse neurological deficit ...(MBL) complement pathways trigger ...
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Paraneoplastic necrotizing myopathy associated with adenocarcinoma of the lung – a rare entity with atypical onset: a case report
... Paraneoplastic necrotizing myopathy is diagnosed on histological examination of biopsy specimens, and is char- acterized by massive necrosis of muscle fibers and very few inflammatory changes. Some cases have focal or ...
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The membrane attack complex, perforin and cholesterol dependent cytolysin superfamily of pore forming proteins
... the membrane attack complex (MAC) in the complement system and perforin, the above-mentioned pore-forming protein that is secreted by activated T-lymphocytes (Tschopp et ...The ...
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Structure of the poly C9 component of the complement membrane attack complex
... the MAC it is anticipated that the MACPF domain of the related complement components C6, C7 and C8 form part of the overall circular assembly 3 ...complete MAC will be positioned at the subunit ...
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Complement induced glomerular epithelial cell injury Role of the membrane attack complex in rat membranous nephropathy
... induces complement (C)-mediated cell-independent ...the membrane attack complex (MAC), we determined the need for C8 in the pathogenesis of proteinuria in an autologous-phase model of ...
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Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis
... the complement system has a central role in neuroinflammation, driving ...and MAC in this process are not yet delineated we investi- gated the explicit effects of C5a and MAC on neuroin- flammation ...
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Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children
... soluble membrane attack complex (sMAC) could serve as an immune biomarker to diagnose bacterial infection in children with ventriculo- peritoneal ...The MAC is a large macromolecular protein ...
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Complement membrane attack complex stimulates production of reactive oxygen metabolites by cultured rat mesangial cells
... which complement membrane attack complexes (MAC) that are deposited in the glomerular mesangium might be pathogenic, we stimulated rat glomerular mesangial cells grown in vitro with nascent ...
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A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells
... the membrane attack complex (MAC) which mediates cell lysis and inflammation and is formed upon complement activation ...Interestingly, MAC formation correlates with AMD severity ...
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Killing of human melanoma cells by the membrane attack complex of human complement as a function of its molecular composition
... The efficiency of the membrane attack complex (MAC) in killing M21 melanoma cells was determined varying the molar ratio of cell-bound C9:C8. It was found that C5b-8 produced functional ...
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The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study
... other complement regulators participate in cell protection from activation of both AP and classical complement pathway ...of membrane-bound comple- ment regulators include the membrane ...
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CD19: a biomarker for B cell development, lymphoma diagnosis and therapy
... multimolecular complex on the surface of mature B cells, alongside complement receptor CD21, and the tetraspanin membrane protein CD81 (TAPA-1), as well as ...
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Activation of terminal components of complement in patients with Guillain Barré syndrome and other demyelinating neuropathies
... associated neuropathy and five of six patients with chronic recurrent polyneuritis. No SC5b- 9 was detected in 10 normal controls. Kinetic studies from six GBS patients showed the highest values of SC5b-9 on the 3rd to ...
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Sécrétions apocrines dans le tractus génital mâle: Roles potentiels dans la maturation des gamètes
... : Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma : CD59 is present on extra- cellular organelles (prostasomes), [r] ...
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Functional Graphs and Their Applications in Generic Attacks on Iterated Hash Constructions
... We note that large body of the knowledge on the statistical properties of the random functional graph can be cited from [FO89], derived using approaches in an independent research area — analytic combinatorics. Actually, ...
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Improving the Big Mac Attack on Elliptic Curve Cryptography
... Big Mac attack against an imple- mentation of ...collision attack, based on the detection of common operands in two ...The attack is very powerful since one single power trace of an ...
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