major histocompatibility complex class II molecules
Molecular Determinants of Peptide Binding to Two Common Rhesus Macaque Major Histocompatibility Complex Class II Molecules
... Major histocompatibility complex class II molecules encoded by two common rhesus macaque alleles Mamu-DRB1*0406 and Mamu-DRB*w201 have been purified, and quantitative binding ...
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Clinical, immunological and genetic features in eleven Algerian patients with major histocompatibility complex class II expression deficiency
... histocompatibility complex class II molecules. MHC class II genes transcription is regulated by four transcription factors: CIITA, RFXANK, RFX5 and ...in major ...
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Development and Use of Multimeric Major Histocompatibility Complex Molecules
... after one in vitro stimulation (33, 43). A number of studies with MHC class II tetramers indicate that the frequency of antigen- specific T lymphocytes, which is in the range of 0.2 to 0.6% of the T cells, ...
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Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression
... restricting major histocompatibility complex (MHC) class I molecules available for investigating virus-specific CTL ...MHC class I-restricted CTL epitopes, we infected five ...
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Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation
... HLA class II downregulation in ...HLA class II must not be considered in ...HLA molecules form only one element in the immunological synapse formed between a T cell and an ...signaling ...
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The role of major histocompatibility complex molecules in luteal function
... Class II MHC molecules, typically expressed on antigen presenting cells of the immune system ...[31]. Class II MHC molecules are heterodimeric proteins composed of non-covalently ...
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Genomic organisation and transcript identification in the class II region of the human major histocompatibility complex
... Since class I assembly occurs in the ER, there must be specific mechanisms by which peptides are generated in the cytoplasm and transported across the ER ...defective class I presentation including the ...
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The Lytic Cycle of Epstein-Barr Virus Is Associated with Decreased Expression of Cell Surface Major Histocompatibility Complex Class I and Class II Molecules
... MHC class I molecules, BZLF1 ⫹ cells expressed reduced levels of surface MHC class II molecules, ranging from 40 to 50% of levels in latent ...MHC class I expression in EBV lytic ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... the major histocompatibility complex (MHC) were named after the discovery that they encode the primary antigens responsible for determining transplant compatibility (Klein 2001), MHC molecules ...
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Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity.
... of major histocompatibility complex (MHC) class I molecules on astrocytes and microglial, endothelial, and ependymal cells was also rapidly induced and followed by induced expression of ...
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Dynamics of major histocompatibility complex class II-positive cells in the postischemic brain - influence of levodopa treatment
... MHC II proteins and the number of MHC II + cells in the lesioned ...MHC II proteins were significantly downregulated we found no differences in the number of MHC II + cells between vehicle and ...
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Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 3 Inhibits Gamma Interferon and Major Histocompatibility Complex Class II Expression
... MHC class I is inhibited by KSHV proteins vIRF-1 (23) and K3/K5 (19) by either down- regulation or degradation of MHC I molecules, ...MHC II presentation by viruses was observed or at least reported ...
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Human Cytomegalovirus-Encoded Immune Modulators Partner To Downregulate Major Histocompatibility Complex Class I Molecules
... modulate major histocompatibility complex (MHC) class I molecule surface expression, thereby hindering antigenic presentation to cytotoxic T lymphocytes ...dependent class I ...
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Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
... MHC class II involve inhibition of transcription (17, ...MHC class II mRNA synthesis (26). Human CMV also inhibits class II trafficking to the cell surface indi- rectly, through ...
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Polymorphism in regulatory gene sequences
... and their receptors, where regulatory polymorphism might be expected to play an unusually important part. Reassur- ingly, increasing evidence indicates that cis-regulatory varia- tion also predominates in the evolution ...
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Prediction of Peptides Binding to Major Histocompatibility Class II Molecules Using Machine Learning Methods
... Major Histocompatibility (MHC) molecules play a sig- nificant role in graft rejection and T-cell ...MHC molecules. Prediction of which peptides can bind to MHC molecules is important to ...
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Conditional CD8+ T Cell Escape during Acute Simian Immunodeficiency Virus Infection
... hierarchy, a characteristic of immunity that is influenced by an individual’s set of MHC class I alleles (1, 13, 19, 21, 27). An alter- nate hypothesis for explaining the differential timing of immune escape is ...
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Physical Association of the K3 Protein of Gamma-2 Herpesvirus 68 with Major Histocompatibility Complex Class I Molecules with Impaired Peptide and β2-Microglobulin Assembly
... the class I heavy chain at a junction between the peptide binding region and the ␣3 domain, a unique interaction site distinct from known ER chaperone binding ...
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Zika Virus Escapes NK Cell Detection by Upregulating Major Histocompatibility Complex Class I Molecules
... To test whether similar findings are observed in primary cells, we infected primary human foreskin fibroblasts (HFF) with Zika virus. We verified the infection (Fig. 3D) and FIG 1 Characterization of NK ligand expression in ...
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Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice.
... Second, this study examined the role of the class II-restricted immune response in demyelinating disease. Although the pre- cise mechanism of TMEV-induced demyelination has not been determined, several ...
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