Mendelian Randomization
Effects of BMI, fat mass, and lean mass on asthma in childhood : a Mendelian Randomization Study
... used Mendelian randomization based on a weighted allele score to estimate the effect of higher BMI in mid-childhood in increasing the risk of childhood ...
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Mendelian Randomization And Single Cell Deconvolution: Two Problems In Statistics Genetics
... by Mendelian random- ization(MR), which uses segregating genomic loci as instrumental variables to estimate the causal effect of a given exposure to disease ...
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High-sensitivity C-reactive protein, low-grade systemic inflammation and type 2 diabetes mellitus: A two-sample Mendelian randomization study
... Genetic instrumental variables for hsCRP serum concentration for the present Mendelian randomization study were selected from a GWAS meta-analysis of Dehghan et. al. [16]. This study is currently the ...
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Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.
... Figure 1. Directed acyclic graph (DAG) showing the instrumental variable (IV) assumptions underpinning a Mendelian randomization analy- sis of circulating IGF levels with prostate cancer. IV models use ...
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Causal association of type 2 diabetes with amyotrophic lateral sclerosis: new evidence from Mendelian randomization using GWAS summary statistics
... A crucial step of MR is to choose appropriate genetic variants to serve as valid instrumental variables for T2D. To do so, we obtained association results from one of the largest T2D GWASs to date [38], which was a ...
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Review Article Plasma total homocysteine and risk of hypertension in pregnancy: a mendelian randomization study
... Despite the significant findings from our curr- ent analysis, some limitations should also be acknowledged. First, although we included six- teen studies with 2188 subjects to investigate the association of MTHFR C677T ...
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Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study
... In the absence of high-quality RCT data, the principles of Mendelian randomization (MR) can be applied to strengthen or refute the causality of diet/lifestyle in T2DM etiology [4]. This approachis based on ...
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Body mass index and breast cancer survival: a Mendelian randomization analysis
... cancer diagnosis was modelled as a function of the expos- ure. This leads to the collider (selection) bias: individuals with a breast cancer diagnosis (and therefore eligible for the Mendelian randomization ...
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Investigating the causal effect of smoking on hay fever and asthma : a Mendelian randomization meta-analysis in the CARTA consortium
... RCTs, Mendelian randomization studies require no random treatment allocation, are more feasible, and often have fewer ethical ...inherent Mendelian randomization assumptions include ...
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Disentangling associations between DNA methylation and blood lipids: a Mendelian randomization approach
... is Mendelian randomization (MR), which uses genetic markers (single-nucleotide polymorphisms [SNPs]) as instrumental variables, taking advantage of the natural randomization that occurs at conception ...
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<p>Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study</p>
... Mendelian randomization (MR) utilizes genetic variants as instrumental variables (IVs) and explore the causal effect between exposure and outcome, but has to meet that the IVs associated with the exposure ...
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Circulating insulin-like growth factors and Alzheimer diseaseA mendelian randomization study
... While mendelian randomization designs are expected to be robust to confounding and reverse causation, the prospect of bias from genetic pleiotropy cannot be completely excluded with current ...
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Taller height as a risk factor for venous thromboembolism:a Mendelian randomization meta analysis
... It is possible that uncontrolled confounding by other risk factors explains the association of height with VTE, so additional techniques in causal inference would be useful to pursue. Genome-wide association studies have ...
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Assessing the role of insulin like growth factors and binding proteins in prostate cancer using Mendelian randomization:genetic variants as instruments for circulating levels
... Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels Carolina B[r] ...
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Dissecting Causal Pathways Using Mendelian Randomization with Summarized Genetic Data: Application to Age at Menarche and Risk of Breast Cancer
... ABSTRACT Mendelian randomization is the use of genetic variants as instrumental variables to estimate causal effects of risk factors on ...that Mendelian randomization estimates of total and ...
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A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes
... Supplemental table 7 SNP lists included in exposure genetic risk score in Mendelian randomization of fasting glucose/T2DM on metabolites (backward approach). T2DM: type 2 diabetes[r] ...
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Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization
... of Mendelian randomization (MR), a method which uses genetic variants associated with an exposure as instrumental variables to infer causality amongst correlated traits [12, ...
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Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study
... Through Mendelian randomization, we investigated genetic evidence for the genetically determined eosinophil in association with each outcomes using individual-level LifeLines cohort data ( n = 13,301), ...
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Age at menarche and lung function: a Mendelian randomization study
... Mendelian randomization (MR) can help assess the causality of an observed association by using genetic variants as proxies, or ‘‘instrumental variables’’, for the exposure of interest [20, ...
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Blood lipids and prostate cancer: a Mendelian randomization analysis.
... However, Mendelian randomization is susceptible to genetic confounding if the SNPs used as instruments for the trait of interest have effects on other phenotypes besides the specific lipid of interest, and ...
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