minor groove binding
Synthesis a novel DNA minor groove binding agents by bis benzimidazole
... DNA minor groove binding, such as Hoechst 33258(Scheme ...high binding affinity of Hoechst 33258, several groups have focused on a strategy to utilize the pharmacophore-like benzimidazole ...
5
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... In the past, protein expression has been analyzed through mRNA studies. However, it was later shown that mRNA content does not correlate with protein con- tent as mRNA is not always translated into protein [16-19]. On ...
9
Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... involving minor groove binders and DNA processing enzymes demonstrate inhibition of the proteins, there are some reports of an increase in enzyme activity in the presence of minor groove ...
227
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... Based on these structural studies, molecular modelling has suggested to us that compound 5 could effectively bind into the DNA minor groove (Figure 1). Then, a series of derivatives with a head-to-head ...
6
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... ligand binding in itself, the disruption of the A- tract structure leads to a closer interaction between ligand and DNA than is possible in the alternating ...that binding to A-tract DNA is better described ...
24
Molecular pharmacology of a series of nitrogen mustard containing-and AT- and GC- recognising minor groove binding agents related to distamycin
... D evelopm ent of the technique closely follow ed the in tro d u ctio n of the M axam and Gilbert chemical sequencing m ethodologies. The original study utilised DNase I as the cleaving agent and studied the b inding of ...
230
Constructing Empirical Likelihood Confidence Intervals for Medical Cost Data with Censored Observations
... major groove, like most TFs, a more effective approach involves using small molecules to form a complex in the minor groove of DNA and allosterically modulate transcription factor ...Typical ...
218
Shape selective recognition of the DNA minor groove by hairpin polyamides
... of minor groove-binding polyamides as tools for genomic analysis and expansion of the minor groove recognition code by designing internal and N-terminal replacements for ...
18
Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders
... of minor-groove binders (MGBs) has expanded vastly and now these compounds display a wide spectrum of biological activities, such as anti- bacterial, antifungal, antiparasitic and anticancer ...of ...
25
DNA Binding Polyamides in Biological Systems
... Minor -groove binding transcription factors, such as TBP Figure 1.3, LEF-l, and TAX, have been excellent targets for polyamide inhibition, resulting in inhibition of RNA polymerase II tr[r] ...
185
The antibacterial drug MGB-BP3 : from discovery to clinical trial
... the minor groove of DNA and details of the configuration of binding were known from X-ray crystallography ...new minor groove binding ...that binding to the non-polar ...
9
Redox status, DNA and HSA binding study of naturally occurring naphthoquinone derivatives
... pressed significant prooxidative activity, while all tested compounds exhibited significant increase in nitrite levels. Also, all examined compounds significantly increased the concentration of oxidized glutathione ...
23
Interaction of DNA with groove binding ligands
... Minor groove binding molecules usually have several simple aromatic rings (benzene, pyrrole etc) connected by bonds with torsional freedom that allow appropriate twisting to enable a good shape fit ...
235
An evaluation of minor groove binders as anti-lung cancer therapeutics
... major groove; however, with the minor groove binding affinity conferred by the distamycin framework, tallimustine has been shown to preferentially monoalkylate the 3’-adenine-N3 atom of ...
11
Detection of the Bacillus anthracis gyrA Gene by Using a Minor Groove Binder Probe
... Identification of chromosomal markers for rapid detection of Bacillus anthracis is difficult because significant chromosomal homology exists among B. anthracis, Bacillus cereus, and Bacillus thuringiensis. We evaluated ...
7
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... that minor groove binding occurs with a staggered 2:1, head-to-tail, side-by-side binding motif 17 at the indicated (underlined) reading ...the binding of 1 to both 5´- d(CGTCTAGACG)-3´ ...
13
Four pyrrole derivatives used as building blocks in the synthesis of minor groove binders
... of minor-groove binders (MGBs) has expanded vastly and now these compounds display a wide spectrum of biological activities, such as anti- bacterial, antifungal, antiparasitic and anticancer ...of ...
24
Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A
... DNA minor groove binding ...of binding and structure is important when trying to understand biomolecular interactions and improving the binding ...
12
Minor groove binders for DNA as antitypanosomal agents : the veterinary context
... to minor groove binding drugs from Strathclyde (S-MGBs) which is important because compounds useful in the field must have activity across the range of infectious species so that ...
19
Localization of DNA binding polyamides in living cells
... the binding characteristics of polyamides on the NCP, several X-ray crystal structures were completed of nucleosome core particles into which had been bound polyamides (Figure ...polyamide binding were ...
37