miRNA binding sites
Imperfect centered miRNA binding sites are common and can mediate repression of target mRNAs
... putative miRNA binding sites affected whether or not a tran- script would be enriched in the pull-down, we fitted a logistic regression model for enrichment status, includ- ing the counts of each ...
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PubMedCentral-PMC4958391.pdf
... predicted miRNA- binding sites of DSB repair genes are associated with risk of SCCHN, we firstly performed bioinformatics predictions for SNPs in the selected DNA DSB repair pathway genes with a ...
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Introns targeted by plant microRNAs: a possible novel mechanism of gene regulation
... predicted miRNA—intron ...likely miRNA—intron interactions. During the first step, the predicted miRNA binding sites along with the 50-nt surrounding sequences at both ends were col- ...
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Partition function and base pairing probabilities of RNA heterodimers
... the binding energy, almost completely destroy the functionality of the binding ...that miRNA binding sites are not functional because of the GU base pairs, testing the dimer with ...
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MicroRNA-related polymorphisms in apoptosis pathway genes are predictive of clinical outcome in patients with limited disease small cell lung cancer
... at miRNA binding sites in the 3 ʹ -UTRs of genes in the apoptosis pathway on the prognosis of patients with limited disease-small cell lung cancer ...suggest miRNA-related polymorphisms in the ...
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MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells
... by binding the 3 ′ UTRs of their target transcripts, it remains interesting to study the relationship between miRNAs and ...RBP-binding sites are often close to miRNA-binding ...
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Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
... illegitimate miRNA binding sites could contri- bute significantly to risk for neurodegenerative ...increased binding of miR-659 to the 3 ’ UTR of the progranulin (GRN) gene provides an ...
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Weinmann, Lasse (2009): Functional characterisation of microRNA-containing Argonaute protein complexes. Dissertation, LMU München: Fakultät für Biologie
... mRNA binding proteins that specifically co- immunpoprecipitate with Ago1 and Ago2 in an RNA-dependent manner, suggesting that miRNPs may act in concert with these mRNA binding proteins to achieve repression ...
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The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes
... putative miRNA-binding sites have been described previously ...putative miRNA-binding sites within these regions predicted using the miRBase (4), miRanda (5), Diana-MicroT (6), ...
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<p>The Biogenesis, Functions, and Roles of circRNAs in Bladder Cancer</p>
... multiple miRNA binding sites, indicating that these EV-carried circRNAs may function as competing endogen- ous RNAs in receipt cells after uptaking EVs from cancer ...
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Diverging Affinity of Tospovirus RNA Silencing Suppressor Proteins, NSs, for Various RNA Duplex Molecules
... This would assume that GRSV and INSV NSs exhibit affinity FIG. 5. Analysis of TSWV NSs interference with the miRNA pathway. EMSA analysis of radioactively labeled miRNA171/miRNA171 * duplex (A) or pre-miRNA2b (B) ...
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Multiple high affinity binding sites for
... (1.2±0.2 mg protein ml −1 ). Following incubation at 25 °C for 45 min, the assay mixture was rapidly filtered under vacuum through Whatman GF/B glass fibre filters using a Brandel cell harvester, and rinsed four times in ...
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Genetic variants of miRNA sequences and non–small cell lung cancer survival
... mature miRNA processing are likely to be pleiotropic and may contribute to cancer susceptibility and ...that miRNA expression patterns have relevance to the bio- logical and clinical behavior of human solid ...
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Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4.
... 4, an ICP4-binding site in the leader is required for activation if additional downstream binding sites are removed; ii the downstream ICP4-binding sites, which are located in the tk gen[r] ...
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CaMELS : In silicoprediction of calmodulin binding proteins and their binding sites
... CaM binding sites within a protein can help biologists in elucidating underlying biological processes at the molecular ...dependent binding and the large sequence diversity of its targets, ...
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Structure prediction, molecular dynamics simulation and docking studies of d-specific dehalogenase from rhizobium sp. Rc1
... It was observed that the minimum constricted segment diameter of the predicted DehD active site channel was at least 0.4 Å. The electrostatic surface into this channel was highly basic compared to the rest of the ...
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A scoring matrix approach to detecting miRNA target sites
... Once the set of SBMs has been computed for each align- ment in , query sequences are then scanned with each of the matrices, and the final score at a given base in a query sequence is taken to be the largest of the ...
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Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network
... perform miRNA microarray analysis using two prostate tissue samples, one from ASPC and the other from CRPC, from the same ...for miRNA microarray analysis [33, ...the miRNA changes in PC patients ...
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Blumhardt, Philipp Paul (2019): Surface-Integrated Fluorescence Correlation Spectroscopy (SI-FCS) for the quantification of transient membrane and surface binding. Dissertation, LMU München: Fakultät für Physik
... docking sites or fluorescent probes is too high to detect them ...and binding dynamics by a combination of TIR-FCS and SI-FCS would further broaden the spectrum of possible applications, ranging from mem- ...
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Comparative analysis between the protein mcp 1 and neurotrophins involved in alopecia areata
... Ligand binding site in Neurotrophins protein family PDB ID 1SG1 Three ligand binding sites were found in PDB ID 1DOK of protein MCP-1, out of which 1 was selected for further docking process, the ...
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