Mouse Cochlea
Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea
... 2014). Co-expression of β -galactosidase or tdTomato with HC markers after damage provided evidence that regenerated HCs were derived from the SC population. In addition, a small percentage of newly generated, ...
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Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea
... rodent cochlea, type I SGN innervation is eliminated from the OHC and type II SGN innervation is eliminated from the IHC (Perkins and Morest, 1975; Echteler, 1992; Simmons, ...the cochlea has been the ...
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Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea
... the mouse cochlea, but there is no no- ticeable effect on HC differentiation in Lfng mutant ...the cochlea [75, ...the cochlea and vestibule, and inhibition of Adam10 after HC loss increases ...
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Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea
... conveys crucial biochemical information throughout the co- chlear sensory epithelium via intercellular Ca 2⫹ waves (Leybaert and Sanderson, 2012; Mammano, 2013). In the immature mouse cochlea, ATP-induced ...
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Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo
... neonatal mouse cochlea is capable of spontaneous hair cell regeneration after damage in ...neonatal cochlea might shed light on the competence of supporting cells to regenerate hair cells and on the ...
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The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea
... However, the research thusfar has been limited by the use of the immunohistochemical staining method. The expression of ET receptor subtypes has not been systematically investigated in the lateral wall of the ...
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Retention of progenitor cell phenotype in otospheres from guinea pig and mouse cochlea
... that mouse adult vestibular sensory epithelia and neonatal organ of Corti tissue harbor cells that, when subjected to suspension culturing, are able to generate floating clonal colonies, the so-called spheres ...
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Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.
... Gata3 homozygous null mice die at early embryonic stages (E10.5–E13.5: Pandolfi et al. 1995; Karis et al. 2001). We studied the effects of gata3 haploinsufficiency in heterozygous null mice in which one gata3 allele was ...
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Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea
... The patterning of this sensory epithelium consists of distinct rows of OHCs and PCs that are organized during embryonic development. To examine differences across this epithelium, we measured stiffness along OHC and PC ...
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Notch Wnt Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner
... Wnt activator added for the first 24 h in vitro suppressed differentiation of the OC when assayed after 6DIV. One interpretation is that the lateral compartment was selectively lost and that HC differentiation was ...
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Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea
... (1:50, mouse monoclonal), anti-β-tubulin III (TUJ-1; 1:1000, mouse monoclonal), anti-NF200 (1:500, mouse monoclonal), anti-BRN3A (1:500, rabbit polyclonal; Milli- pore), anti-synaptophysin (SYP; ...
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Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea
... inhibiting p27Kip1 in cochlea [59, 60]; here, we also observed the similar results. Our qRT-PCR results with the injured cochleae also showed that after Wnt activation with BIO treatment, the expression of Jag1, ...
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Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea
... neonatal cochlea, but not in the mature cochlea (Figure 8G) because of age-related changes of these ...maturing cochlea (72, ...the cochlea develops and matures (78), thus a more comprehensive ...
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Original Article Spatiotemporal expression of Bmi1 in the developing mouse cochlea
... Abstract: Bmi1 is a member of the Polycomb protein family and has been reported to play important roles in regu- lating the survival of auditory hair cells. However, the detailed expression profile of Bmi1 during ...
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Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications
... the mouse cochlea is reached around postnatal (P) day 8 (P8, where P0 indicates date of birth) ...the cochlea, which in rodents appears around P5 and increases progressively to reach adult levels (in ...
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Claudin expression during early postnatal development of the murine cochlea
... in mouse cochlea during postnatal development and localized the expression in separated fractions of the ...the cochlea of Slc26a4 −/− mice compared to Slc26a4 +/− ...
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Neurosensory development and cell fate determination in the human cochlea
... the mouse cochlear duct, and the onset of hair cell ...the cochlea showed PRPH positivity (Figure 8A, white arrow), as well as type II SGNs in adult mouse cochlea that had been processed ...
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Electrical properties of Deiters cells of the mammalian cochlea
... the cochlea, the organ of Corti is innervated by several individual nerves, afferent and efferent, which enter the cochlea through the modiolus (Spoendlin 1985, Bredberg ...the cochlea, while the ...
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A “Tric” to tighten cell cell junctions in the cochlea for hearing
... TJs were not integrated into typical tTJs at the center of TC regions. A similar pheno- type was seen at the TCs in the utricular macula (vestibular organ). These obser- vations clearly demonstrate that tricel- lulin is ...
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Towards a better understanding of cochlear mechanics: A new cochlear model
... The purpose of modelling cochlear mechanics is to gain a better understanding of the operation of the real cochlea by the formulation and analysis of models that reflect the structure an[r] ...
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