mRNA processing
Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes
... We have identified several expressed sequence tags (ESTs) that indicate expression of IL4I1 in tissues other than B lymphocytes, namely human and mouse testis and brain. This expression of the IL4I1 gene was apparently ...
12
Full length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing
... Conservation of interdependencies across human tissues We investigated whether the interdependent transcrip- tion initiation, splicing, and polyadenylation events iden- tified in MCF-7 cancer cells could also be found in ...
18
Concentration and localization of co-expressed ELAV/Hu proteins control specificity of mRNA processing
... regulated mRNA processing plays a major role in synaptic plasticity Although ELAV in Drosophila is expressed as soon as neurons are born, it is mostly not required for neuronal development with the ...
58
Suppressor Analysis of Mutations in the 5′-Untranslated Region of COB mRNA Identifies Components of General Pathways for Mitochondrial mRNA Processing and Decay in Saccharomyces cerevisiae
... a loss-of-function in 59 trimming of COB pre-mRNA, we To examine the molecular nature of the pet127 genes decided to survey genes encoding known components in group II suppressor strains, the genes were amplified ...
12
The Epstein-Barr Virus (EBV) SM Protein Enhances Pre-mRNA Processing of the EBV DNA Polymerase Transcript
... pre-mRNA/mRNA processing events, including splicing and nuclear shuttling ...in mRNA nuclear export (31, ...pre- mRNA processing ...
8
hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase 9 pre mRNA processing
... hnRNP L regulates the AIG and tumorigenic capacity of NSCLC cells via the pre-mRNA processing of caspase-9. Modulation of the levels of splice variants of caspase-9 had dramatic effects on AIG and the ...
18
A small deletion distant from a splice or polyadenylation site dramatically alters pre-mRNA processing in region E3 of adenovirus.
... Thus, we identified two phenotypic groups of mutants that have novel effects on alternative pre-mRNA processing, one group exemplified by d1719, in which mRNA f is made Most tumor virus [r] ...
8
The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre mRNA processing gene during neural crest development
... ABSTRACT The functions of gene regulatory networks that control embryonic cell diversification occur on a background of constitutively active molecular machinery necessary for the elaboration of genetic interactions. The ...
16
<p>Pre-mRNA Processing Factor 8 Accelerates the Progression of Hepatocellular Carcinoma by Regulating the PI3K/Akt Pathway</p>
... Background: The speci fi c function of pre-mRNA processing factors (Prps) in human malignancies has not been yet investigated. The aim of the present study was to determine the impacts of Prp8 in a common ...
14
Autorepression of Epstein-Barr Virus Nuclear Antigen 1 Expression by Inhibition of Pre-mRNA Processing
... pre-mRNA processing appears to be strictly dependent on the context of the EBNA-1 binding sites within the gene ...pre-mRNA processing in general that occurs soon after initi- ation of ...
9
Pre-mRNA Processing Factor Prp18 Is a Stimulatory Factor of Influenza Virus RNA Synthesis and Possesses Nucleoprotein Chaperone Activity
... pre-mRNA processing factor 18 (Prp18) as a stimulatory factor for viral RNA synthesis using a Saccharomyces cerevisiae replicon system and a single-gene dele- tion library of Saccharomyces cerevisiae ...
11
Kaposi's sarcoma-associated herpesvirus ORF57 protein: exploiting all stages of viral mRNA processing
... either mRNA export or viral replication ...viral mRNA export ...that mRNA export can still occur, albeit at a slightly lower level ...viral mRNA to facilitate mRNA export ...of ...
24
Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene
... The IRF1 gene does not have a typical TATA box, although there is an AT rich sequence starting at -38 relative to the TSS, and it does appear to have a CCAAT box at -99 and a GC box at -162. Its TSS is defined by a ...
17
Map of cis-acting sequences that determine alternative pre-mRNA processing in the E3 complex transcription unit of adenovirus.
... mRNA f levels may be increased for the same reason that they are increased by deletions in region II, i.e., deletions in region III, by decreasing the ability of cleavage and/or polyaden[r] ...
10
Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9
... Among the genes that were differentially regulated in the two ES cell lines, we focused on DHX9 because of its reported functional interaction with EWS-FLI1 [17]. DHX9, also known as RNA helicase A (RHA) or nuclear DNA ...
18
Splice site skipping in polyomavirus late pre-mRNA processing.
... Since the VP1' exon retains only 81 nt deriving from the wild-type VP1 exon [14 nt adjacent to the VP1 3' splice site and 67 nt just upstream of the polyA site], exon skipping is not lik[r] ...
8
Removal of the polyglutamine repeat of ataxin-3 by redirecting pre-mRNA processing
... Several studies that use antisense oligonucleotides (AOs) to modify the mRNA of ATXN3 by attempting to remove the CAG containing exon have been conducted [8–10]. Until now, van Roon-Mom and colleagues have ...
15
trans-acting regulation of bovine leukemia virus mRNA processing.
... Based on densitometric analyses, levels of P-globin mRNA directed by pBGRS-1, 2, and 3 containing various portions of the 3' terminus of the virus were from 10 to 20 times higher when ce[r] ...
5
Splice site selection in polyomavirus late pre-mRNA processing.
... To determine whether the relative strength of the various 3' splice sites dictates the ratio of spliced products in polyomavirus late pre-mRNA, constructs containing duplicated or rearra[r] ...
8
MicroRNA and mRNA Processing Variations in Normal and Hypertrophic Hearts
... is associated with shorter 3’UTRs (Takagaki and Manley, 1998, Takagaki et al., 1996). Furthermore, co- depletion of CSTF2 and its paralogue CSTF2 τ in HeLa cells resulted in longer 3’-UTRs. Somewhat surprisingly, the ...
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