Multicellular spheroids
A systematic multicellular spheroids screening approach lead to the identification of antineoplastic activity in three different plant extracts from the Egyptian flora
... The multicellular spheroids model was used to select the most active extracts after a cancer monolayers ...carcinoma spheroids and safe to normal human epithelial cells spheroids and showed ...
10
Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids
... Another interesting observation came from the impact of ATP depletion in DXR retention. For this experiment we used a metabolic cocktail poison to be certain of the ATP pools depletion. However, this treatment was unable ...
13
Transitioning from multi-phase to single-phase microfluidics for long-term culture and treatment of multicellular spheroids
... of multicellular spheroids, such as the potential for higher throughput screening and the use of reduced cell numbers, whilst providing increased stability for plate ...of multicellular ...
10
Doxorubicin-mediated radiosensitivity in multicellular spheroids from a lung cancer cell line is enhanced by composite micelle encapsulation
... A549 multicellular spheroids were incubated with drug- loaded micelles and ...the spheroids, and flow cytometry was used to quantitate the doxorubicin fluorescence signal intensity, because ...
11
<p>Reversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2</p>
... Purpose: Peritoneal metastasis is the most common pathway for the spread of ovarian cancer. Ovarian cancer cells in ascites prefer to aggregate into the more chemoresistant multicellular spheroids (MCSs), ...
10
Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids
... years, multicellular spheroids (MCSs) have been widely used for drug-sensitivity and molecular mechanism studies to investigate the difference in bio- logical characteristics and phenotypic expression not ...
11
Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma
... A549 multicellular spheroids, whose 10th re-proliferated generations were employed as radioresistant cells, and the control groups were A549 parental cells and MCF7/VCR resistant ...
5
Receptor tyrosine kinase targeting in multicellular spheroids
... of multicellular spheroids into experimental design is becoming increasingly ...as spheroids tend to replicate the in vivo situation more reliably than monolayer ...of multicellular ...
8
BIGH3: A Negative Regulator of Human Osteosarcoma Large Multicellular Spheroids
... small spheroids and different osteosarcoma cell lines will help access the extent, if any, that BIGH3-mediated apoptosis explains, at least in part, the mechanism underly- ing BIGH3’s antagonism on tumor ...
22
Emulsion technologies for multicellular tumour spheroid radiation assays
... Emulsion-based technologies are becoming popular tools for the formation and culturing of multicellular spheroids and organoids. 14–20 Such methods involve the encapsulation of cell aggregates or cell ...
13
Chemical analysis of multicellular tumour spheroids
... of multicellular spheroid growth were performed by Holtfreter 10 who was studying gastrulation, and Moscona and Moscona 11 who demonstrated the aggregation of isolated chick chondro- genic and myogenic ...tumour ...
11
Effect of single walled carbon nanotubes on tumor cells viability and formation of multicellular tumor spheroids
... of multicellular tumor spheroids ...of multicellular tumor ...of multicellular spheroids was compared with the results obtained by culturing tumor cells with ultra dispersed diamonds ...
9
A Review on the Recent Advancement in “Tumour Spheroids‑on‑a‑Chip”
... 3D spheroids was continued, and they were then treated with an anti-cancer drug, also through fluid ...line spheroids showed increased resistance to treatment in multicellular spheroids ...
9
SIZE AND SHAPE FACTOR EXTREMES OF SPHEROIDS
... oblate spheroids (see ...oblate spheroids, while the pair (V, S) is used for prolate ...prolate spheroids later in the study when it is more ...
10
Seven challenges in the multiscale modelling of multicellular tissues
... If every researcher implemented their own model from scratch we would have thousands of implementations of each model at a massive overall time cost. The solution to this is to develop and use computational tools to ...
26
Protein A mediated multicellular behavior in Staphylococcus aureus
... whether protein A needs to be anchored to the cell wall to promote multicellular behavior or if secreted protein A might be functional. We first examined the levels of protein A in the supernatants of ISP479r agr, ...
12
Multicellular Group Formation in Saccharomyces cerevisiae
... Here, we propose bakers yeast, Saccharomyces cerevisiae, as an ideal model for studying the very first stages of the evolution of multicellularity as a major evolutionary transition in individuality (Figure 1). This is ...
14
Roland Thaxter's legacy and the origins of multicellular development.
... REICHENBACH (1 962) concluded that the formation of fruiting bodies generally passed through several stages: vegetative growth of a multicellular swarm, induction by starva[r] ...
6
Gene Regulatory Networks Controlling Multicellular Development.
... Predicting gene regulatory networks by combining spatial and temporal gene expression data in Arabidopsis root stem cells. A Summary of Drosophila Embryogenesis[r] ...
340
Priority Traffic Modeling in Multicellular Communication Networks
... The high priority users forced ter- mination probability can be evaluated by taking into account the fact that an active high priority user may switch from one cell to another more than [r] ...
12