Nonnucleoside reverse transcriptase inhibitors
A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and ...
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Mutants of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Demonstrate Altered Rates of RNase H Cleavage That Correlate with HIV-1 Replication Fitness in Cell Culture
... (HIV-1) reverse transcriptase (V106A, V179D, and Y181C), which occur in clinical isolates and confer resistance to nonnucleoside reverse transcriptase inhibitors (NNRTIs), were ...
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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.
... potent inhibitors of NNRTI-resistant ...broad-spectrum inhibitors involved the in vitro screening of a diverse series of BHAP analogs against recombinant RTs car- rying either the Pro-2363Leu or Tyr-1813Cys ...
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... The effects of combined drugs (NNRTI plus NNRTI) on HIV-1 mutation frequencies were analyzed. In general, the virus mutation frequencies observed in the presence of com- bined drugs were significantly increased compared ...
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Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... known nonnucleoside reverse transcriptase inhibitor (NNRTI) ...(HIV-1) reverse transcriptase ...nucleoside reverse transcriptase inhibitors (zidovudine [AZT] and ...
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Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites
... Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from ...
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Comprehensive In Vitro Analysis of Simian Retrovirus Type 4 Susceptibility to Antiretroviral Agents
... SRV-2, inhibitors with anti-SRV-4 activity have not yet been ...HIV reverse transcriptase inhibitors, zidovudine (AZT) and tenofovir disoproxil fumarate (TDF), potently inhibited SRV-4 ...
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Altered Viral Fitness and Drug Susceptibility in HIV-1 Carrying Mutations That Confer Resistance to Nonnucleoside Reverse Transcriptase and Integrase Strand Transfer Inhibitors
... Nonnucleoside reverse transcriptase inhibitors and integrase inhibitors are used to treat infection with ...verse transcriptase and integrase interact and that some mutations can ...
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A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance
... The nonnucleoside reverse transcriptase inhibitors (NNR- TIs) are potent and selective inhibitors of human immunode- ficiency virus type 1 (HIV-1) ...HIV-1 reverse ...
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Nonnucleoside Reverse Transcriptase Inhibitor-Resistant HIV Is Stimulated by Efavirenz during Early Stages of Infection
... Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and commonly prescribed antiviral agents used in combination therapy (CART) of human immunodeficiency virus type 1 (HIV-1) ...
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Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... which reverse transcriptase is provided by HIV-1 RT (TyHRT) ...by nonnucleoside reverse transcriptase inhibitors (NNRTIs) in yeast (26), the assay can be performed in the ...
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Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... (HIV-1) reverse transcriptase which are involved in the regulation of resistance to nonnucleoside reverse transcriptase inhibitors ...nucleoside reverse ...
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Divergent Evolution in Reverse Transcriptase (RT) of HIV-1 Group O and M Lineages: Impact on Structure, Fitness, and Sensitivity to Nonnucleoside RT Inhibitors
... The impact of divergent group O evolution on phenotype can be difficult to interpret. Previous studies indicate that re- combinant group O RT is virtually indistinguishable from group M subtype B RT based on in vitro ...
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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs
... ABSTRACT Two mutations, G112D and M230I, were selected in the reverse trans- criptase (RT) of human immunodeficiency virus type 1 (HIV-1) by a novel nonnucleo- side reverse transcriptase inhibitor ...
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Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors
... retroviruses. Nonnucleoside reverse transcriptase (RT) inhibitors such as nevirapine are highly selective for HIV-1 (50), whereas the nucleoside RT inhibitor (NRTI) azidothymidine (AZT) ...
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Virtual Screening for Novel HIV-Reverse Transcriptase Inhibitors
... world. Reverse transcriptase, protease and integrase are coded by the gag and gag–pol genes of HIV that shows a significant role in the repetition cycle of ...Viral reverse transcriptase (RT) ...
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Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase.
... not, by themselves, appear to be important in determining the sensitivity of HIV-1 RT to TBA, HEPT, or calanolide A, it is still possible that these substitutions could have an effect if[r] ...
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High frequency of Fredrickson's phenotypes IV and IIb in Brazilians infected by human immunodeficiency virus
... protease inhibitors plus nucleoside reverse transcriptase inhibitors increased the levels of cholesterol and triglycerides in these patients when compared with naïve ...
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Volume 2 | Issue 4 - 2012
... 13. Matthews, C.Z. Woolf, E.J. Mazenko, R.S. Haddix- Wiener. H. Chavez-Eng, C.M. Constanzer, M.L. Doss, G.A. and Matuszewski. B.K. Determination of efavirenz, a selective non-nucleoside reverse ...
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Comparative Study of Various Non-Nucleoside Reverse Transcriptase Inhibitors on Different Reverse Transcriptase Enzyme
... nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/ NTRIs) and non-nucleoside reverse tran- scriptase inhibitors (NNRTIs), protease inhibitors and HIV integrase ...
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