Nrf2-ARE Pathway
The Keap1/Nrf2-ARE pathway as a pharmacological target for chalcones
... the Nrf2 and NF-κB pathways, such as Keap1, IKK, NF-κB, ERK1/2, JNK and p38-MAPK (Figure ...the Nrf2 and NF-κB response pathways can synergize in the overall anti-inflammatory ...between Nrf2 ...
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Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle
... increased Nrf2-ARE binding activity, Nrf2 protein, and mRNA expressions of Nrf2-mediated antioxi- dant genes in mouse skeletal muscle, longer duration associated with higher responses, in which the ...
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Original Article Effects of that ATRA inhibits Nrf2-ARE pathway on glial cells activation after intracerebral hemorrhage
... the Nrf2 inhibitor [18, 19], ATRA, to treat the ICH rat ...of Nrf2, and could inhibit the bingding of Nrf2 to ...the Nrf2 activa- tion and potential mechanism, we observed the Nrf2-ARE ...
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The effect of resveratrol and its methylthio-derivatives on the Nrf2-ARE pathway in mouse epidermis and HaCaT keratinocytes
... on Nrf2 activation in mouse epidermis and human HaCaT ...of Nrf2 from the cytosol to the nucleus as an effect of stilbene treatment in both ...of Nrf2 translocation was the parent compound, ...
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Original Article Lactose induced redox-dependent senescence and activated Nrf2 pathway
... Furthermore, western blotting analysis of Nrf2 and mRNA expression of its downstream genes suggested the Nrf2/ ARE pathway was involved in the oxidative stress induced by lactose. These results were ...
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Mechanisms underlying the perifocal neuroprotective effect of the Nrf2–ARE signaling pathway after intracranial hemorrhage
... Dovepress nrf2–are pathway correlates with intracranial hemorrhage The Nrf2–ARE signaling pathway is a promising new target for the study of the treatment of ...that Nrf2 is an ...
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Baicalin provides neuroprotection in traumatic brain injury mice model through Akt/Nrf2 pathway
... However, there are some limitations in the present study. First, some other Nrf2 upstream factors (eg, p38MAPK, JNK, and protein kinase C) also have significant impacts on Nrf2- ARE pathway. 32 ...
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Anthocyanins protect human endothelial cells from mild hyperoxia damage through modulation of Nrf2 pathway
... alterations acting as cell signaling modulators and inducing activation of the Nrf2/ARE pathway. Thus, the present findings contribute to support the hypothesis that plant polyphenols, including ...
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Original Article The role of Keap1-Nrf2-ARE signal pathway in diabetic retinopathy oxidative stress and related mechanisms
... of Nrf2/ARE pathway related proteins were measured to investigate functional role and mechanism of Keap1-Nrf2-ARE signal pathway in ...and Nrf2 proteins were quantified by Western ...
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Original Article Glutamine ameliorates intestinal ischemia-reperfusion Injury in rats by activating the Nrf2/Are signaling pathway
... the Nrf2/ARE pathway induced by GLN in a rat ...the Nrf2 and HO-1 were significantly elevated by GLN pretreatment when compared to the I/R ...of Nrf2 onto Bcl2 gene ...
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Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1
... releases Nrf2 from Keap1-mediated inhibition promoting persistent activation of a pano- ply of cytoprotective genes implicated in cellular responses to oxidative stress and regulation of inflammatory ...of ...
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Regulation of the Keap1–Nrf2 pathway by p62/SQSTM1
... Abstract Nrf2 is a transcription factor responsible for gene expression of a series of anti-oxidant proteins and detoxifying ...of Nrf2, leading to Nrf2 ...nonical pathway, one Nrf2 ...
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Glutaredoxin-1 regulates the Keap1-Nrf2 pathway
... The Nrf2/Keap1/ARE signaling pathway is a major regulator of cytoprotective responses with many downstream targets including detoxification enzymes and antioxidants that collectively function to reduce ROS ...
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Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes
... cytosolic Nrf2 in addition to in- creased nuclear Nrf2 suggests that PDTC may stimulate de novo synthesis of ...in Nrf2. Keap1 is a negative regulator of Nrf2 that promotes cytosolic ...
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The Pharmacological Manipulation of the Nrf2 Pathway and Its Therapeutic Significance
... of Nrf2 inhibition by brusatol in mouse Hepa-1c1c7 hepatoma ...of Nrf2, it was of interest to define the mechanism of action of this ...of Nrf2 protein was found to be independent of changes in the ...
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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
... Keap1-Nrf2 pathway is the major regulator of cytoprotective responses to oxidative and electrophilic ...factor Nrf2 prevent cancer initiation and progression in normal and premalignant tissues, in ...
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Mechanotransduction in Living Bone: Effects of the Keap1-Nrf2 Pathway
... Moderate Nrf2 Activation via Partial Deletion of Keap1 The results of this study suggest a subtle sex-dependent effect of the moderate Nrf2 activation resulting from partial deletion of its sequestering ...
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A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes
... Brie fly, 10 mg of nuclear extracts from each sample in triplicate were incubated in a 96-well plate that was coated with oligonu- cleotide containing a consensus binding site for Nrf2. For compe- titive binding ...
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Molecular investigation of Keap1-dependent regulation of the Nrf2 cell defence pathway
... factor Nrf2 is activated in response to chemical and oxidative stress and induces the expression of antioxidants and detoxification ...enzymes. Nrf2 activity is regulated by its cysteine-rich repressor ...
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A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds.
... 4.1. Nrf2-Related Research: Expanding and Evolving from the Bench to the Bedside This bibliometric analysis of Nrf2-related literature to date revealed some interesting and useful ...of Nrf2-related ...
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