PML nuclear bodies
Emerging Role of PML Nuclear Bodies in Innate Immune Signaling
... as PML nuclear bodies (PML-NBs) or nuclear domains 10 ...(ND10). PML-NBs are dynamic foci that consist of numerous permanently or transiently associated pro- teins and, ...
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An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm
... on PML nuclear bodies. PML is prominently expressed in reticuloendothelial cells (12), the most frequent targets of arenavirus infection ...makes PML a candidate for the nuclear ...
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An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies
... the nuclear import of the genomes (28), while the fate of polypeptide X/Mu is ...after nuclear import, protein VII marks viral genome complexes in cells ...at PML-NBs (5). In this report, however, ...
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PML-nuclear bodies decrease with age and their stress response is impaired in aged individuals
... that PML monitors a basic aging process and not the effects of a disease ...of PML-NBs compared to healthy ...of PML as a sensor of cellular stress and a mediator of DNA damage response is strongly ...
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MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus
... Sp100, PML, and other PML NB protein components are recruited to HSV-1 ge- nomes entering the nucleus of an infected cell in a process that contributes to the repression of viral gene transcription (54, 55, ...
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Targeting Promyelocytic Leukemia Protein: A Means to Regulating PML Nuclear Bodies
... targets PML for proteosome-dependent degradation. The decrease in PML protein levels cor- relates with a decrease in PML NB ...(65). PML-RAR α , is also subject to mSiah-2-mediated ...
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Epstein-Barr Virus Nuclear Antigen 1 Hijacks the Host Kinase CK2 To Disrupt PML Nuclear Bodies
... to PML NBs by EBNA1 results in increased phosphorylation of PML by CK2, as evi- denced by the EBNA1-induced increase in phosphoserine ...on PML triggering the polyubiquitylation and degradation of ...
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Resistance to Rabies Virus Infection Conferred by the PMLIV Isoform
... implicate PML and PML nuclear bodies (NBs) in an intrinsic antiviral response targeting diverse cytoplasmic replicating RNA ...viruses. PML conjugation to the small ubiquitin-like ...
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Apoptin Nucleocytoplasmic Shuttling Is Required for Cell Type-Specific Localization, Apoptosis, and Recruitment of the Anaphase-Promoting Complex/Cyclosome to PML Bodies
... of PML nuclear bodies (11, 23, ...10), PML nuclear bodies play an integral role in apoptotic processes and have been proposed to serve as a “hub” for nuclear apoptotic ...
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Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
... appears to be one of the key factors determining the choice between TA and ALT. In this regard, the presence of one or more epigenetic repressors determining the TA to ALT switch has been known from years [34]. One of ...
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Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies
... (PML) nuclear bodies (NBs) in P3HR1 cells during the viral lytic cycle, appearing as nuclear speckles under a confocal laser scanning ...with PML-NBs in vitro. BORF1 also colocalizes ...
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Mitosis, Not Just Open or Closed
... a nuclear envelope during mitotic entry restricts the attachment of spindle microtubules to only chromosomes within that nucleus ...no nuclear envelope under these circumstances, microtubules could ...
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Exotic mitotic mechanisms
... to nuclear pores [54,61] (figure ...a nuclear channel, but builds a ‘conventional’ exospindle that laterally attaches to the nucleus ...inner nuclear membrane on a precursor that is associated to ...
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DAXX promotes ovarian cancer ascites cell proliferation and migration by activating the ERK signaling pathway
... To explore the role of DAXX on ascites cells, we har- vested and cultured ascites cells in DMEM medium (Fig. 2a). Western blot examination revealed that the as- cites cells were positive for GFP-DAXX (Fig. 2b), which ...
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Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures.
... and PML 16 h later; representative results from several hun- dred Vmw110-positive cells are presented in ...of PML (Fig. 5A and B). In fact, PML was undetectable in many cells expressing wild-type ...
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Nuclear dynamics: where genes are and how they got there
... and nuclear location is provided by the inactivated human X chromosome, or Barr ...the nuclear periphery was no longer ...the nuclear periphery and gene ...
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Höge, Carsten (2002): RAD6-abhängige DNA-Reparatur wird durch Ubiquitin- und SUMO-Modifikation von PCNA reguliert. Dissertation, LMU München: Fakultät für Biologie
... sogenannten PML-Körpern (PML bodies or nuclear ...Strukturen. PML ist ein RING-Finger Protein und reguliert Zellwachstum über seine proapoptotischen Eigenschaften (Fogal et ...2000). ...
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Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
... and PML knockout 129/SV-PML tm1Ppp mice (29) were a kind gift from Pier Paolo Pandolfi (Beth Israel Deaconess Cancer ...and PML expression ...vivo PML expression, the indicated organs were ...
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Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response
... reduced PML expression (Fig. 11B and F and data not shown). These effects on PML were not a conse- quence of the specific sequence of the shRNA against PIAS4, as other evaluated PIAS4-specific shRNAs had ...
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Identification of repressive and active epigenetic marks and nuclear bodies in Entamoeba histolytica
... while the second is located between amino acids 10 and 11, and the third is located after amino acid 14 [5]. This last insertion site merits particular attention due to the presence of three extra lysine residues, which ...
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