polycomb repressive complex 1
Genome-wide RNAi screen in Drosophila reveals Enok as a novel trithorax group regulator
... the Polycomb Group (PcG) and the trithorax Group (trxG), that contribute to the maintenance of cellular memory ...complexes, Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2), are ...
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Polycomb Repressive Complex 2 Silences Human Cytomegalovirus Transcription in Quiescent Infection Models
... of Polycomb repressive complex 1 (PRC1), thereby stimulating PRC1-mediated ubiquitylation of H2A on lysine 119 (H2AK119ub) ...preinitiation complex forma- tion ...virus 1 ...
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Gene silencing in HIV 1 latency by polycomb repressive group
... termed polycomb repressive complex 1 (PRC1) and 2 (PRC2) ...smaller complex that comprises three main proteins (EZH2, EED and SUZ12) and catalyzes his- tone H3K27me3 ...to ...
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Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development
... the Polycomb group (PcG) proteins are one of the best characterized (Schuettengruber and Cavalli, 2009; Lanzuolo and Orlando, 2012; Di Croce and Helin, 2013; Simon and Kingston, ...complexes, Polycomb ...
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Choi, Jeongyoon (2016): Structural and functional analysis of polycomblike-polycomb repressive complex-2. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... This complex was called as Polycomb repressive complex-2 (PRC2; Kuzmichev et ...after Polycomb repressive complex-1 (PRC1), which had been purified by Kingston and ...
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The Polycomb Group Protein Bmi1 Binds to the Herpes Simplex Virus 1 Latent Genome and Maintains Repressive Histone Marks during Latency
... virus 1 (HSV-1) establishes latency in sensory neurons is largely ...whether Polycomb group proteins, which methylate H3K27, were present on the HSV-1 genome during ...the Polycomb ...
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Drosophila DNA-Binding Proteins in Polycomb Repression
... Figure 1. Functional activities of Drosophila Polycomb group (PcG) ...The Polycomb response element (PRE) shown as brown horizontal bar: DNA sequence depleted of nucleosomes (slanted ovals) on which ...
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Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2
... Fig. 4 Transcriptional and post-translational responses to cold exposure. a Venn diagram showing overlap in upregulated genes between 4-week- vernalized vs non-vernalized (4v > 0v) and hypoxia vs normoxia 21 (hyp > ...
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EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation
... PRC2 complex is composed of core subunits (EED, EZH1/2, SUZ12, and RBBP4/7) required for enzymatic activity, and accessory subunits (PCLs, JARID2, AEBP2) that regulate the recruitment and activity of PRC2 ...three ...
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Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β catenin signaling
... We have shown that PRC2 subunits are expressed in retinal progenitors, indicating a possible role in retinal proliferation and/or differentiation (Fig. 1; supplementary material Fig. S1A-D) (Aldiri and Vetter, ...
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Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma
... the mean), we initially hypothesized that acquired resist- ance was mediated by genetic variants that were enriched in the population over the course of the dose escalation. To identify possible resistance-associated ...
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Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
... PRC2-Ezh1 complex on the MyoG promoter raise ques- tions as to its functionality during skeletal muscle cell ...this complex has a role in the subsequent resilencing of MyoG in terminally differentiated ...
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Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy
... To isolate miRNA, mirVana microRNA Isolation Kit (Ambion, Austin, TX) was used. Cells were collected using and centrifuged at 200 × g for 4 minutes. The cell pellet was washed, transferred to a centrifuge tube and spun ...
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Deregulated expression of microRNA-200b/c and SUZ12, a Polycomb repressive complex 2 subunit, in chemoresistant colorectal cancer cells
... The observed phenotype of DLD-1-OxR cells, based on morphological characteristics and increased cell migration, indicated that the chemoresistant cells had transitioned to a mesenchymal phenotype. A hallmark of ...
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Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background
... (Table 1): (1) Drosophila contains four core proteins: enhancer of zeste E(Z); suppressor of zeste 12 SU(Z)12; extra sex combs (ESC) and the histone binding protein ...such complex is involved in ...
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BRCA1 deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2 inhibitor 3 deazaneplanocin A
... The SMARTpool small interfering RNA (siRNA) targeting Ezh2 and the non-targeting control were purchased from Dhar- macon (Lafayette, CO, USA). Prior to all knock-down experi- ments optimal transfection conditions were ...
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Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
... of polycomb repressive complex 2 (PRC2), regu- late differentiation and plasticity of CD4 + T ...chromatin repressive mark H3K27me3 in activated ...PRC2 complex to target genes and ...
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Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia
... reported repressive STAT5 TFBS located in the promoter region of MEF2C were implicated in T-cell leukemia, we performed sequence analyses of a 750 bp stretch in seven selected T-ALL cell lines (CCRF-CEM, JURKAT, ...
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Predicting involvement of polycomb repressive complex 2 in direct conversion of mouse fibroblasts into induced neural stem cells
... of polycomb repressive complex 2, Ezh2, Suz12, Mtf2, and Jarid2 are grouped as master regulators in four cell lines based on the number of regulatory interactions and also show the same pattern of ...
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Polycomb repressive complex 2 is a critical mediator of allergic inflammation
... Mice were immunized with an intraperitoneal injection of 200 μl alum/OVA containing 20 μg low-endo- toxin OVA (Wοrthington) and 2.25 mg aluminium hydroxide (Sigma-Aldrich) in sterile PBS on day 0 and day 7. Mice were ...
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