Potential anticancer agents
Design, synthesis and biological evaluation of some novel Schiff base derivatives as potential anticancer agents
... as potential anticancer ...The anticancer activity of these compounds was evaluated using Sulforhodamine-B (SRB) assay method ...showed anticancer activity against bothHEPG2 and MCF7 cancer ...
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Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants
... known anticancer drug targets, including tyrosine kinase, protein kinase B β, cyclin-dependent kinase, protein farnesyltransferase, human protein kinase, glycogen synthase kinase, and indoleamine 2,3-dioxygenase ...
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Metal complexes as potential anticancer agents
... Despite its success, cisplatin has a num ber o f draw backs. Testicular cancer accounts for less than 1% of all malignancies encountered, thus its actual spectrum of activity is limited. Dose limiting toxic side effects ...
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Design, synthesis, and cytotoxicity evaluation of new 2,4-disubstituted quinazolines as potential anticancer agents
... novel anticancer agents with minimal side effects (Eckhardt, 2002; El-Azab et ...ideal anticancer agents, which eradicate the cancer cells without involving the normal ...
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Synthesis and biological evaluation of new pyrrolobenzodiazepines, tetrazoles and quinazolinone derivatives as potential anticancer agents
... This chapter describes the design, synthesis, and biological evaluation of tetrazole linked isoxazoline/cinnamides as anticancer agents and tubulin polymerarization inhibitors. Tubulin is a heterodimeric ...
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Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC “click” chemistry as potential anticancer agents
... antitumor agents. All of the compounds were evaluated for anticancer activity against a panel of three human cancer cell lines, including MCF-7 (breast), SW-1990 (pancreatic), and SMMC-7721 (liver) and the ...
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Synthesis, characterization and in vivo biological evaluation of novel benzimidazoles as potential anticancer agents
... We further analyzed the effect of 8d on ascites volume and cell number in the intraperitoneal tumor of drug-treated and control mice. We observed a significant decrease in the body weight after the administration of 8d ...
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Synthesis of novel substituted a methylamino derivatives of a santonin as potential anticancer agents Part 1: Eudesmanolide derivatives
... the anticancer activity of more readily accessible compounds related to (3) but derived from the readily available α-santonin, using parthenolide (1) as the positive ...
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Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents
... mortality worldwide; it was accountable for 8.2 million deaths in 2012 according to the World Health Organization statistics, and its incidence is expected to increase to 13.0 million by 2030. Consequently, immense ...
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2D QSAR Study of Imidazothiazole Propenones Derivatives as Potential Anticancer Agents by DFT QSAR Models
... experimental anticancer activity against lung adenocarcinoma epithelial cell line with t en calculated molecular descriptors has led to relatively successful QSAR models that relate this pharmacological and ...
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Recent advancements in Uracil and 5-Fluorouracil hybrids as potential anticancer agents: A review
... The second approach deals with a combination of two or more drugs with the help of linker or spacers. The compounds of this category are also recognized as combi-molecules and the connection can be done via a cleavable ...
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Natural and synthetic coumarins as potential anticancer agents
... in anticancer drug development due to a fact that many of its derivatives have shown an anticancer activity on various cell ...as potential anticancer drugs is given, which can serve as an ...
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Synthesis and evaluation of L-glutamic acid analogs as potential anticancer agents
... for anticancer activity in vitro in DU-145 and PC-3 prostate cancer and in COLO-205 colon cancer cell lines by MTT ...for anticancer activity in vitro in colon (COLO-205), breast (Zr-75-1) and prostate ...
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6,7 seco ent kauranoids derived from oridonin as potential anticancer agents
... genus Isodon thus far, including mainly ent-kaurenes, 6,7-seco-ent-kaurenes, and 8,9-seco-ent-kaurenes. 6 Several ent-kaurenes like oridonin (1, Scheme 1) and its analogues have been studied extensively for the ...
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SYNTHESIS, IN VITRO ANTICANCER AND MOLECULAR DOCKING STUDIES OF NEW BISISATINS AS ANTICANCER AGENTS
... Receptor tyrosine kinases (RTKs) are high affinity cell surface receptors were proved to be a viable target for anticancer drug development. [4-6] They are the second most important drug targets after G protein ...
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Phenolic Acids from Parthenium hysterophorus: Evaluation of Bioconversion Potential as Free Radical Scavengers and Anticancer Agents
... DPPH is a nitrogen centered free radical which gives strong absorption maximum at 517 nm. The change in color of solution from yellow to purple occurs as the singlet electron in DPPH free radical becomes paired with ...
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ANTICANCER POTENTIAL OF SOLANUM JASMINOIDES
... Cytotoxicity is the result of the molecular interactions of an alkaloid with one or several important targets present in a cell. The main targets include DNA, RNA, and the associated enzymes and related processes (i.e., ...
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Evaluation of Anticancer Potential of Caffeine
... After the time intervals the viable naupliis were counted. The numbers of survivors were counted and % death was calculated. Larvae were considered dead if they did not having any internal or external movement during ...
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ANTICANCER POTENTIAL OF α MANGOSTIN
... Existing anticancer treatment such as chemotherapy, surgery, and radiotherapy can only offer some benefits to cancer patients because toxicity issues and is not specific to cancer cells ...a potential ...
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Multinuclear ruthenium(II) complexes as anticancer agents
... a single chlorido ligand on each metal centre – were synthesised and found to be significantly more active than cisplatin against two breast cancer cell lines. The anticancer activity appears to be due to a ...
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