Programmed cell death 1 ligand 2
Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy
... grammed cell death protein 1 (PD-1). PD-1 is expressed by T cells and interacts with its ligands programmed cell death protein ligand 1 (PD-L1) and ...
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Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
... To calibrate PD-L1 expression relative to the proportion of tumor cells present in the RC specimen, alternate sec- tions were subjected to H&E staining and anti-PD-L1 IHC prior to evaluating PD-L1 expression. In the ...
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A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction
... Accumulating evidence has demon- strated that the PD-1/PD-L1 pathway plays an important role in regulating the immune-inflammatory response during sepsis, as sepsis can upregulate PD-L1 expression on a variety of ...
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The Expression of Programmed Death Ligand-1 within Stages of Oral Squamous Cell Carcinoma: Immunohistochemical Analysis
... Out of 140 participants, around 74% were men (n=103) in contrast to women (26%, n=37). PD- L1 positivity was found in 62.1% of samples (n=87) and the major portion of PD-L1 positive cases belonged to males. (76%, n=66). ...
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<p>A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer</p>
... Patients and methods: Adult patients with histologically or cytologically documented Stage IIIB/Stage IV/recurrent/progressive NSCLC, Eastern Cooperative Oncology Group performance status 0 to 3, and >2 lines ...
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Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma
... ing, 1 for weak staining, 2 for moderate staining, and 3 for strong ...scored 1, 26%–50% scored 2, 51%–75% scored 3, and 76%–100% scored 4 ...− 1) were used to determine the optimal ...
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Immune checkpoint therapy in liver cancer
... (CTLA-4), programmed cell death protein-1 (PD-1), and programmed cell death ligand 1 (PD-L1), have been identified to suppress anti-tumor immune ...
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The expression status and prognostic significance of programmed cell death 1 ligand 1 in gastro­intestinal tract cancer: a systematic review and meta-analysis
... Studies meeting the following criteria were eligible for the single-arm meta-analysis of PD-L1-positive expression rate on tumor cells: (1) cohort studies which investigated PD-L1 expression level in ...
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Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
... A total of 143 lung adenocarcinoma samples were collected from 84 females and 59 males. The mean age of the patients was 58.6 years, ranging from 36–79 years. Detailed clini- copathologic and molecular characteristics ...
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<p>BTLA Expression in Stage I–III Non–Small-Cell Lung Cancer and Its Correlation with PD-1/PD-L1 and Clinical Outcomes</p>
... small- cell lung cancer (NSCLC), which accounts for 80% of lung cancers, and most are diagnosed at an advanced ...stage. 1 The curative ability of traditional treatment — radiotherapy and chemotherapy — is ...
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Programmed death-ligand 1 is upregulated in intrahepatic lymphoepithelioma-like cholangiocarcinoma
... 7 (CK7) (Clone OV-TL 12/30, Dako A/S, Denmark), anti-cytokeratin 19 (CK19) (Clone RCK108, Dako A/S, Denmark) and anti-PD-L1 (Clone SP263, Ventana, Tucson, AZ, USA). Omission of primary antibody and substitution by ...
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Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... CD86, programmed death (PD-1), programmed death ligand 1 (PD-L1), paired immunoglobulin-like receptor B (PIR-B) or T-cell proliferation in serum, spleen homogenate, ...
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Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study
... its ligand PD-L1 limits T cell activation in response to certain antigens in order to prevent immune-mediated damage in healthy ...T cell “exhaus- tion” and reduced immune control of tumor ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... on cell surface, while upregulate its nuclear expression in breast cancer cells ...on cell surface is expected to increase the immunogenicity of the cancer cells, and its translocation to the nucleus is ...
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Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis
... T cell exhaustion [3]. T cell exhaustion was first described in states of chronic viral infection with persistent high levels of antigen exposure ...cytotoxic cell death in targeted cells ...T ...
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<p>Immune checkpoint inhibitors for small cell lung cancer: opportunities and challenges</p>
... cancer death worldwide, with an estimated ...small cell lung cancer (SCLC) is the most aggressive type of lung cancer, it shows high response rates to chemotherapy in early lines of ...and programmed ...
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Intralymphatic histiocytosis in a patient with lung adenocarcinoma treated with pembrolizumab: a case report
... non-small- cell lung cancer (NSCLC) [1, ...anti-programmed death (PD-1) antibody, has shown favorable antitumor efficacy in NSCLC patients [1, ...of programmed ...
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<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... Several studies have shown that PD-1 inhibitor coupled with CTLA-4 inhibitor has a more effective treatment outcome on brain metastasis of NSCLC. Since the dual immune blocking mode was approved by the FDA for ...
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Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer
... vent cell-mediated lysis. In addition, the expression of PD-1 in tumor infiltrating lymphocytes is another key point of immune escape mediated by PD-1/PD-L1 ...T cell activation and inhibiting ...
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<p>Prognostic and clinicopathological value of PD-L1 in colorectal cancer: a systematic review and meta-analysis</p>
... Such as breast cancer, 42 renal cell cancer, 43 lung cancer, 44 glioma. 45 In colorectal cancer, this is in agreement with the study by Hamada et al, 19 which indicated the association of PD-L1 overexpression and ...
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