Protein Dynamics
Intermolecular interactions and protein dynamics by solid state NMR spectroscopy
... investigating the influence of different intermolecular inter- actions and packing on molecular dynamics. In our compar- ison we take advantage of the fact that relaxation rates in the solid state are sensitive to ...
7
Clustering and Protein Dynamics of Drosophila melanogaster Telomeres
... the dynamics of their associated ...“replicate” protein components alongside DNA with every cell ...matin, protein dynamics during replication are ...the protein component present at ...
17
Direct observation of hierarchical protein dynamics
... between protein dynamics and ...the protein conformational energy landscape that underlies these motions based on a series of temperature-dependent magic-angle spinning multinuclear NMR relaxation ...
9
Protein Dynamics and Entropy: Implications for Protein-Ligand Binding
... of protein dynamics to macromolecular interactions is not fully ...NMR-derived protein dynamics. First, we demonstrate that NMR dynamics do not correlate well between the solid and ...
186
Protein dynamics and conformational selection in bidirectional signal transduction
... the protein conformers that are most complementary to some preexisting ligand conforma tions are/may be preferentially ...Therefore, protein confor mational dynamics can preencode functional ...
5
Internal protein dynamics shifts the distance to the mechanical transition state
... Mechanical unfolding of polyproteins by force spectroscopy provides valuable insight into their free energy landscapes. Most phenomenological models of the unfolding process are two-state and/or one dimensional, with the ...
6
Envelope Protein Dynamics in Paramyxovirus Entry
... attachment protein that lead to the activation and subsequent refolding of ...attachment protein links receptor engagement to F triggering remained poorly ...
9
Capturing Protein Dynamics with Time Resolved Luminescence Spectroscopy
... the dynamics of unfolded proteins, frustration manifests as internal friction, slowing intrachain diffusion in regions of the ...conformational dynamics in the unfolded state [14, 15, 16, ...
147
Circulating protein synthesis rates reveal skeletal muscle proteome dynamics
... muscle protein synthesis rates further supports the idea of using a repre- sentative and accessible protein, such as CK-M or CA-3 in plasma, to represent general protein dynamics in ...
16
Hydrogen-Deuterium Exchange Mass Spectrometry and Molecular Dynamics Simulations for Studying Protein Structure and Dynamics
... of protein dynamics can be used to extract information related to the general behavior of proteins in different biophysical/biochemical ...study protein dynamics are still relatively ...
177
Protein structural dynamics and thermodynamics from advanced simulation techniques
... the protein to explore efficiently the phase space, for what concerns dynamics the situation becomes more ...a dynamics of a process, as it will explained better in the dedicated Chapter, but this ...
153
Protein Hydrogen Exchange, Dynamics, and Function
... a protein, we compared the general dynamic behavior of the protein to the BHO ...stable protein undergoing fluctuations around the minimum energy ―native state‖ ...the protein dynamics ...
220
Spectroscopic Probes of Protein Structure, Dynamics, Hydration and Electrostatics
... A central dogma of biology concisely states that 'sequence determines structure determines function'. While this is generally considered an over-simplification, it does assert that it should be possible to deduce the ...
198
Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw
... extend a tufted primary dendrite radially and structurally and functionally distinct lateral dendrites horizontally (Imamura and Greer, 2009). Likewise, apical/basal dendrites of hippocampal neurons and ...
12
HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures
... HECTD1. HEK293 cells were stably transfected with GFP-IQGAP1 and seeded on fibronectin-coated dishes for 60 min, protein lysates were harvested and immunoprecipitated (IP) by GFP antibody. The lP lysates and whole ...
16
Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
... evolutionary dynamics are characterized by the survival of only a small number of lineages from year to year, which form the trunk of the evolutionary tree, and many short-lived branches of lineages that come to a ...
13
Structure and Dynamics of the Membrane Protein Bacteriorhodopsin Studied by Mass Spectrometry
... overall dynamics with enhanced solvent access to formerly protected amide ...The protein remains active even after extensive continuous illumination (Figure 6-2, green and blue lines), mimicking the ...
217
Ef-G:trna Dynamics During the Elongation Cycle of Protein Synthesis
... In this thesis, the kinetics of EF-G catalyzed translocation is investigated by both ensemble and single molecule fluorescence resonance energy transfer studies to further explore the underlying mechanism. In the ...
233
Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
... ABSTRACT Protein thermodynamics are an integral determinant of viral fitness and one of the major drivers of protein ...(HA) protein can eliminate neutralizing antibody binding to me- diate escape ...
14
Molecular dynamics and protein function
... lar dynamics programs, large amounts of computer time, and examples for which molecular dynamics has really played a role in furthering our understanding of protein functions, we look forward to a ...
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