Proteolipid Protein
Serial MR Imaging of Experimental Autoimmune Encephalomyelitis Induced by Human White Matter or by Chimeric Myelin Basic and Proteolipid Protein in the Common Marmoset
... fusion protein of myelin- basic and proteolipid protein) in adjuvant along with intravenous inactivated pertussis vaccine to facilitate the disease ...
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HLA DR2–restricted responses to proteolipid protein 95 116 peptide cause autoimmune encephalitis in transgenic mice
... In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA- DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and clonal- ly ...
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Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein
... basic protein (MBP) and proteolipid protein ...tolerogenic protein for the therapy of patients with MS, we have produced a protein fu- sion between the ...MP4 protein is highly ...
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DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)
... basic protein (MBP), proteolipid protein (PLP), and more recently, myelin oligodendrocyte glycoprotein (MOG), myelin-oligodendrocytic basic protein (MOBP), oligodendrocye specific ...
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Induction of circulating myelin basic protein and proteolipid protein specific transforming growth factor beta1 secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
... basic protein (MBP) and proteolipid protein (PLP), induced anti- gen specific MBP or PLP reactive T cells that either secreted IL-4, TGF- b 1, or alternatively did Th1 type sensitization occur as ...
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Targeting DEC-205−DCIR2+ dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis
... The target of the fusion antibody in the present study was Dendritic cell inhibitory receptor 2 (DCIR2), which is a transmembrane protein with a single C-type II lectin domain (Nussenzweig et al., 1982; Steinman ...
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Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain
... PLP is the major myelin protein of the CNS. Point muta- tions and deletions/duplications of the PLP1 gene are as- sociated with X-linked dysmyelinating leukodystrophies, PMD and SPG2 [33]. Duplication of the ...
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MR Revealed Myelination in the Cerebral Corticospinal Tract as a Marker for Pelizaeus Merzbacher's Disease with Proteolipid Protein Gene Duplication
... Myelination in the cerebral corticospinal tract the internal capsule, corona radiata, centrum semiovale, pre- or postcentral cortex, and subcortical white matter, optic radiation, and co[r] ...
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MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS
... used. Proteolipid protein (PLP) , which is a prominent neu[oantigen, was extracted from fresh bovine brain, and used for inducing EAE in female Balb/e and Guinea ...
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The Roles of Lysosomal Exocytosis in Regulated Myelination
... myelin protein synthesis, storage and transportation are key elements of myelination, however the mechanisms of regulating myelin protein trafficking are still not very ...myelin-resident protein, as ...
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Gamma Interferon Signaling in Oligodendrocytes Is Critical for Protection from Neurotropic Coronavirus Infection
... the proteolipid protein promoter (10) demonstrated increased numbers of infected oligodendro- cytes without altering the extent of demyelination or tissue destruction ...
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Reactivity to myelin antigens in multiple sclerosis Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
... basic protein (MBP) and proteolipid protein (PLP), are likely to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune responses to other myelin antigens, in particular ...
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Experimental allergic encephalomyelitis in cynomolgus monkeys Quantitation of T cell responses in peripheral blood
... basic protein (MBP), but not to proteolipid protein, were detected in peripheral blood mononuclear cells (PBMC) of all animals and persisted until their death or, in surviving animals, for greater ...
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Prediction of milk protein concentration from elements of the metabolizable protein system
... Failure to obtain improved prediction using starch and WSC rather than their sum (QFC) may indicate that both have similar effects with regard to the availability of energy for the synthesis of microbial protein. ...
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The molecular determinants and consequences of recombination in the evolution of human enteroviruses
... Replication-dependent recombination in plant and animal viruses requires RNA templates and viral replicase for successful template switching to occur. The simplest model suggests that two RNA templates are necessary, ...
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<p>MWCNT interactions with protein: surface-induced changes in protein adsorption and the impact of protein corona on cellular uptake and cytotoxicity</p>
... reason, protein binding is a key factor for reducing ...of protein adsorption on the cyto- toxicity of different types of MWCNTs, we measured LDH ...without protein corona led to a higher LDH ...
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Protein-protein interactions
... The docking of one protein with another is a complex process that involves two basic types of complementarity; geometric and chemical. The majority of docking algorithms are based upon methods of evaluating and ...
221
Algorithmic approaches to protein-protein interaction site prediction
... data, protein structural datasets are non-standardized and virtually all structure-based predictors have varying criteria for processing and fil- tering this ...query protein, whether by structural, ...
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Comparative modeling and docking studies of p16ink4/Cyclin D1/Rb pathway genes in lung cancer revealed functionally interactive residue of RB1 and its functional partner E2F1
... in protein-protein ...through Protein-protein binding may provide a basis for designing a suitable drug for preventing this widely spreading disease by using the information retrieved about ...
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Predicting the Functions of Unknown Protein by Analyzing Known Protein Interaction: A survey
... The Protein complexes from PPIs are responsible for the important biological processes about the cell and learning the functionality under these biological process need uncovering and learning complexes and ...
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