Proton channels
Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA 2activity
... or proton channels by the PKC inhibitors, GFX ...of proton channels may also be less straightforward than direct phosphorylation of the channel molecule by ...the proton channel itself ...
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Symposium: “Voltage-Dependent Proton Channels Come of Age” at the Biophysical
... “Voltage-gated Proton Channels: pH-dependent and Voltage- Dependent Gating, Proton Channel ...ion channels.” Chaired Symposium: “Voltage-Dependent Proton Channels Come of Age” at ...
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Philosophy of voltage-gated proton channels
... ion channels, the proton channel adopts two functional con- ...voltage-gated proton channel gene was not identified until 2006 ...contain proton pathways (or channels) that are ...
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VOLTAGE-GATED PROTON CHANNELS: MOLECULAR BIOLOGY, PHYSIOLOGY, AND PATHOPHYSIOLOGY OF THE H V
... voltage-gated proton channels knows that the result obtained depends strongly on careful minimization of pH changes due to H ⫹ current during the prepulse, as well as residual pH changes from pulses applied ...
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Voltage-gated proton channels: what’s next?
... voltage-gated proton channels that remain ...the proton channel, most of the obvious and less obvious structure–function questions are still wide ...the proton channel protein strongly ...
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Voltage-gated proton channels help regulate pH in rat alveolar epithelium
... cell patch-clamp studies; conceivably the gating of H ⫹ chan- nels in intact cells might be different. This raises the intriguing possibility that voltage-gated proton channels may be active in these cells ...
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Potassium Channels, or Both? During the Respiratory Burst, Do Phagocytes Need Proton Channels or
... implication is that these metals do not inhibit NADPH oxidase activity in phagocytes by inhibiting proton channels, but instead Fig. 1. The “respiratory burst” in a phagocyte is triggered when a bac- terium ...
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Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis
... one proton into the cytoplasm, and regen- eration of NADPH produces a second proton via the hexose monophosphate ...one proton, via either proton channels or H-ATPase, there should be ...
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The intimate and mysterious relationship between proton channels and NADPH oxidase
... voltage-gated channels are opened or activated by ...gated proton channel has the unusual prop- erty of existing in two profoundly different operational states, or ‘‘gating ...cells, proton ...
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A RT I C L E The Antibacterial Activity of Human Neutrophils and Eosinophils Requires Proton Channels but Not BK Channels
... Electrophysiological events are of central importance during the phagocyte respiratory burst, because NADPH oxi- dase is electrogenic and voltage sensitive. We investigated the recent suggestion that large-conductance, ...
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Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating
... In some studies, green fluorescent protein (GFP)-tagged proton channels were studied. More often, GFP was co-transfected with the proton channel construct. Fluorescent cells were identified in the ...
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DIVERSITY OF VOLTAGE GATED PROTON CHANNELS Deri Morgan and Thomas E. DeCoursey
... channels are sensitive to voltage, with an open probability that increases with membrane depolarization. Many properties that are shared by voltage-gated proton channels make them unique among ion ...
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Thomas E. DeCoursey The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase
... age-gated proton channels in human neutrophils (1–3, ...reported proton currents in human cell lines (179, ...functional proton channels in human neutrophils came from Sergio Grinstein ...
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Voltage-Gated Proton Channels and Other Proton Transfer Pathways
... and proton fluxes are carried through separate molecules, in contrast to a number of molecules important in bioener- getics, in which electron and proton movement is strictly coupled (51, 130, 194, 394, ...
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Absence of Proton Channels in COS-7 Cells Expressing Functional NADPH Oxidase Components
... voltage-gated proton channels in phagocytes is thought to be to provide a mechanism of charge compensation for the electron efflux through NADPH oxidase (Henderson et ...
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Voltage-Gated Proton Channels
... similar proton currents in Ambystoma salamander oocytes ...that proton channels were genuine ion chan- nels and that protons did not simply permeate other channels adventitiously (29, ...hibit ...
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Abstract: Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary
... of proton channels by PMA suggest that a likely mechanism is phosphoryla- tion of the channel protein, perhaps by protein kinase C (PKC) [149, ...the proton flux stimulated by chemotactic peptides, ...
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Review Voltage-gated proton channels
... that proton channels were molecular entities distinct from other ion channels ...own channels and did not simply permeate other ion channels adventitiously), that proton ...
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Voltage-gated proton channels in microglia
... ion channels is not explicitly required, but the belief is so widespread that the channel’s hydrophilic interior is key to the ability of charged ions to permeate, that ‘water-filled’ has be- come part of the de ...
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Deuterium Isotope Effects on Permeation and Gating of Proton Channels in Rat Alveolar Epithelium
... 1 channels really ion channels? In Table IV deute- rium isotope effects on various membrane transporters other than channels are ...1 channels are not water-filled pores, should they be ...
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