Purifying selection
A Multiorgan Trafficking Circuit Provides Purifying Selection of Listeria monocytogenes Virulence Genes
... ABSTRACT Listeria monocytogenes can cause a life-threatening illness when the food- borne pathogen spreads beyond the intestinal tract to distant organs. Many aspects of the intestinal phase of L. monocytogenes ...
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Purifying Selection, Drift, and Reversible Mutation with Arbitrarily High Mutation Rates
... under purifying selection may be close to or even greater than rates at neutral sites with high b ...of purifying selection is con- sistent with the patterns described by Cutter et ...weak ...
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An Important Role for Purifying Selection in Archaeal Genome Evolution
... of selection can be approximately measured by the genome-wide dN/dS ratio (ratio of nonsynonymous to synonymous substitution rates) for orthologous genes shared by closely related lineages, and the stronger the ...
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Divergent evolution and purifying selection of the flaA gene sequences in Aeromonas
... The ω ratios inferred under the model M8 were scattered along the codon sites, with the highest values clustering in the region between codon 105 and 205 (Fig. 5). We applied the fixed-site models to our data in order to ...
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The Structure of Genealogies in the Presence of Purifying Selection: A Fitness-Class Coalescent
... of purifying selection are broadly similar to an effec- tive population size that changes as time recedes into the ...when selection is com- mon (Williamson and Orive ...
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Simultaneous Positive and Purifying Selection on Overlapping Reading Frames of the tat andvpr Genes of Simian Immunodeficiency Virus
... Darwinian selection favoring amino acid replacements of an epitope of simian immunodeficiency virus ...and purifying selection on the vpr reading frame, by limiting acceptable nonsynonymous ...
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Purifying Selection Causes Widespread Distortions of Genealogical Structure on the Human X Chromosome
... natural selection affects genealogical ...positive selection is under- stood to decrease nucleotide variability, shorten the time to most recent common ancestor (TMRCA), and increase the length of haplotype ...
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The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations.
... with the well-known fact that most nonsynonymous mutations are deleterious (Pal et al., 2006; Eyre-Walker and Keightley, 2007), and are therefore kept at low frequencies in the population by purifying ...
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Extensive purifying selection acting on synonymous sites in HIV 1 Group M sequences
... of selection, because nonsynonymous substi- tution rates are compared against a rate which is no longer a good estimate of the neutral rate, and this is likely to result in inference of diversifying ...
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Distortions in Genealogies due to Purifying Selection and Recombination
... As selection becomes weaker and these assumptions are violated, correlations between the lineages become important, topological distortions will arise, and our anal- ysis breaks ...of purifying ...
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Stabilizing Selection, Purifying Selection, and Mutational Bias in Finite Populations
... stabilizing selection rather than purifying ...stabilizing selection on genomic traits, the effects of mutational bias on the equilibrium value of a trait under stabilizing selection in a ...
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The Effect of Strong Purifying Selection on Genetic Diversity
... linked purifying selection changes patterns of neutral genetic diversity in a process known as background ...background selection reduces neutral genetic diversity, it also leads to significant ...
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Detecting Amino Acid Sites Under Positive Selection and Purifying Selection
... positive selection are used to compare the Nei ...positive selection) of the SLR cient data, applying some variants of the NY method to and SNY ...positive selection is extremely difficult and so, ...
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Phylogenomic analysis reveals genome-wide purifying selection on TBE transposons in the ciliate Oxytricha
... different 57kD genes, consistent with both increased variation in and the possible expanding roles of the 57kD protein. One type of the TBE2.2 terminal inverted repeat is precisely 21 bp shorter than the TBE2.1 TIR. It ...
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Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses
... of selection analysis results, not including the MaHV5 gene, since it could not be aligned for the entire length (219 gaps in a 384-nucleotide ...positive selection according to the BEB analysis are ...
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Selection on the Genes of Euplotes crassus Tec1 and Tec2 Transposons: Evolutionary Appearance of a Programmed Frameshift in a Tec2 Gene Encoding a Tyrosine Family Site-Specific Recombinase
... under purifying selection in Tec1 and ...under purifying selection for the function of its encoded protein, as evidenced by a dearth of nonsynonymous ...
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Comprehensive genomic analysis reveals dynamic evolution of endogenous retroviruses that code for retroviral-like protein domains
... under purifying selection, and have maintained high transcriptional po- ...under purifying selection, using the new transcript data, in combination with cap analysis of gene expres- sion ...
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The Effects of Background and Interference Selection on Patterns of Genetic Variation in Subdivided Populations
... and selection. In the interference selection regime of many tightly linked selected sites, forward simulations provide evidence that neutral diversity patterns obtained from both the nonequilibrium and ...
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Comparative Analyses of Selection Operating on Nontranslated Intergenic Regions of Diverse Bacterial Species
... purifying selection in this species. It has been argued that weak purifying selection in ...if purifying selection is ...and purifying selection (Farhat et ...
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Constraints on HIV-1 Diversity from Protein Structure
... positive selection in both subtypes in gag and env, indicating similar selection pressures on both HIV-1 lineages, although this pressure may differ in strength ...in selection have previously been ...
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