PVP K30
ENHANCEMENT OF SOLUBILITY OF EFAVIRENZ EMPLOYING β -CYCLODEXTRIN, POLOXAMER 407 AND PVP K30: PHASE SOLUBILITY AND FACTORIAL STUDIES
... and PVP for enhancing the solubility and dissolution rate of poorly soluble drugs have been investigated individually, no reports are available on their combined use in enhancing the solubility and dissolution ...
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A FACTORIAL STUDY ON FORMULATION DEVELOPMENT OF EFAVIRENZ TABLETS EMPLOYING Β CYCLODEXTRIN POLOXAMER 407 PVP K30
... – PVP K30 (2%) binary mixture (c); EF - βCD (1:2) – PVP K30 (2%) ternary complex (ac); EF – Poloxamer 407 (2%) - PVP K30 (2%) ternary complex (bc); EF - βCD (1:2)- Poloxamer 407 ...
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PRECLINICAL PHARMACOKINETIC EVALUATION OF EFAVIRENZ βCD POLOXAMER 407 PVP K30 INCLUSION COMPLEXES
... Pharmacokinetic evaluation was done on (i) Efavirenz; (ii) Efavirenz - βCD (1:2), (iii) Efavirenz – βCD (1:2) – Poloxamer 407(2%) and (iv) Efavirenz - βCD (1:2) - PVP K30 (2%) solid inclusion complexes in ...
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DEVELOPMENT AND CORRELATION BETWEEN IN VITRO DRUG RELEASE AND IN VITRO PERMEATION OF THERMALLY TRIGGERED MUCOADHESIVE IN SITU NASAL GEL OF REPAGLINIDE PVP K30 COMPLEX
... (PVP K30/ PEG 6000/ poloxamer 188) in different weight ratios. REP: PVP K30 (1:5) was selected as the optimized SD as it showed highest enhancement in solubility ...
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DESIGN, OPTIMIZATION AND EVALUATION OF BUCCAL DRUG DELIVERY SYSTEM OF PROPRANOLOL FOR HYPERTENSION TREATMENT
... A 3 2 randomized full factorial design method was used in this study. In present design- two factors are selected for evaluation, each at three levels, and experimental work was carried out at all nine possible ...
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FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING BIOADHESIVE SUBLINGUAL FILM OF SUMATRIPTAN
... E5/PVP k30 and their combinations along with different concentration of ...with PVP K30 have potential for consideration for drug delivery through ...
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A Combined Conjugation and Hybridization Technology for Different Types of DNA and Nanoparticles
... solvents, PVP-k30 is often used as the binder for medicine in ...addition, PVP-k30 has been applied to silver nanoparticles to protect them by preventing the generation of hydrazine hydrate on ...
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<p>Eudragit<sup>®</sup>-S100 Coated PLGA Nanoparticles for Colon Targeting of Etoricoxib: Optimization and Pharmacokinetic Assessments in Healthy Human Volunteers</p>
... Etoricoxib-loaded nanoparticles were successfully devel- oped, according to the D-optimal design, via the nanospray drying technique. M14 system was prepared using PLGA (0.5% w/v) at a lactide:glycolide ratio of 100:0, ...
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DEVELOPMENT AND IN-VITRO EVALUATION OF MATRIX-TYPE TRANSDERMAL PATCHES OF LOSARTAN POTASSIUM
... Methods: Four transdermal patches formulations of Losartan potassium were prepared by using different polymers using blends of different polymers like polyvinylpyrrolidone K30 (PVP K30) and ...
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Enhancement of Solubility and Dissolution Properties of Lacidipine by Solid Dispersion
... with PVP-K30 and poloxamer-188(1: 2, 1: 4, 1: 6, 1: 8 and 1: 10 %w/w) shown in figure 6 and ...with PVP-K30 and ...of PVP-K30 and Poloxamer-188, it was revealed that the solid ...
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Development Characterization and Evaluation of Nasal in situ Gel containing Anti-Asthmatic Drug
... Drug content was estimated for all the batches, and it was found to be in the range of 80 – 92%. The results are shown in Table 5. It shows that as the concentration of HPMC K100M, PVP K30, and Lutrol F ...
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FORMULATION & OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF SIMVASTATIN USING RESPONSE SURFACE METHODOLOGY
... and PVP K30 (X2) were taken as the independent variables and the in vitro dissolution (Y1), t50% (Y2) and mean dissolution time (Y3) as dependent ...
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Formulation and evaluation of solid dispersions of Flurbiprofen for dissolution rate enhancement
... Drug and carriers physical mixture were prepared by slightly grinding drug Flurbiprofen and carriers (PEG 6000, PVP K30 and Urea) in mortar for 2 min at the required drug/carriers ratio as shown in Table 2. ...
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FORMULATION AND EVALUATION OF SOLID DISPERSION INCORPORATED FAST DISINTEGRATING TABLETS OF TENOXICAM USING DESIGN OF EXPERIMENT
... CL, PVP K30 and Poloxamer 127, in 1:1:1,1:2:1 and 1:3:1 by using solvent evaporation method was incorporated in the fast disintegrating tablets shown highest drug ...
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Enhancement of Solubility and Dissolution Rate of Racecadotril through Solid Dispersion Methods.
... Akiladevi.D et al., 2011. Preparation And Evaluation Of Paracetamol By Solid Dispersion Technique. The solid dispersion of paracetamol by physical triturating method, and fusion method were prepared using 1:1, 1:4 and ...
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Journal of Applied Pharmaceutical Science
... either PVP K30 or SLS or both have markedly enhanced the solubility and dissolution rate of efavirenz, a BCS class II drug than is possible with them ...– PVP K30 and efavirenz – βCD – SLS ...
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FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF LISINOPRIL
... In-vitro permeation studies was carried out using franz diffusion cell for 5 hour duration by withdrawing samples at specific time intervals. The permeation of the drug into the mucosa is dependent on the nature of ...
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STUDIES ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF RITONAVIR EMPLOYING ? CYCLODEXTRIN, SOLUPLUS AND PVPK30
... The CD complexes were prepared by kneading method. All the solid inclusion complexes of ritonavir- βCD - Soluplus /PVP K30 prepared were found to be fine and free flowing powders. Low coefficient of ...
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FORMULATION AND EVALUATION OF SPHERICAL CRYSTAL AGGLOMERATES OF NISOLDIPINE
... 6000, PVP and PVP K30 byusing Quassi emulsification solvent diffusion technique for enhancement of solubility, flowability, packability of ...
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Formulation development and evaluation of transdermal patch of piroxicam for treating dysmenorrhoea
... The piroxicam matrix transdermal patches were fabricated by the solvent evaporation technique utilizing different ratios of HPMC E15, ethyl cellulose, and PVP K30 (3:1, 3:2, and 2:1), respectively. In the ...
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