receptor ligands
gp130 receptor ligands as potential therapeutic targets for obesity
... gp130 receptor ligands may play as potential therapeutic targets in ...gp130 receptor ligands as part of a therapeutic strategy to treat ...
10
PPAR γ receptor ligands: novel therapy for pituitary adenomas
... PPAR-γ receptor ligands, such as rosiglitazone, is proposed for managing patients harboring GH- and PRL-secreting pituitary tumors, which are unresponsive to dopamine agonists and somatostatin ...
9
Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
... A 2,5-disubstituted pyrrolidine has been identified as the major alkaloid in skin extracts of Dendrobates histrionicus, a population of a Colombian dendrobatid frog. Such 2,5-disubstituted pyrrolidines (Table 2.1) were ...
131
A multiple classifier system identifies novel cannabinoid CB2 receptor ligands
... After virtual screening a further reduction of hits is required to ensure a chemically diverse set of prospec- tive ligands for in vitro testing. Compounds identified as active by D2-MCS classifier were clustered ...
14
Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
... acetylcholine receptor has become the target in understanding various health consequences involved in smoking and its mechanisms of ...Nicotinic receptor ion channels are also opened by ...acetylcholine ...
127
Flavonoids as GABA<sub>A</sub> receptor ligands: the whole story?
... Abstract: Benzodiazepines are the most widely prescribed class of psychoactive drugs in current therapeutic use, despite the important unwanted side effects that they produce, such as sedation, myorelaxation, ataxia, ...
16
The synthesis and biological evaluation of d myo inositol 1,4,5 trisphosphate receptor ligands
... Alternative uses and resolution of orthoester derivatives In addition to the orthoformate 49, other orthoesters of myo-inositol such as orthoacetate 71 and orthobenzoate 72 have been use[r] ...
383
receptor ligands
... [25] Epix Pharmaceuticals, Inc. October 29, 2007 press release; http://www.epixpharma.com [26] R. Nirogi, R. Kambhampati, A. Shinde, V. Kandikere, K. Mudigonda, G. Bhyrapuneni, P. Jayarajan, R. abraham, S. Mulla, V. ...
10
ALX receptor ligands define a biochemical endotype for severe asthma
... signals, SPMs, which are partially defined by their ability to inhibit granulocyte recruitment and activa- tion in inflamed tissues as well as to promote macrophage-mediated clearance of dead cells, microbes, and debris ...
15
Design and synthesis of 5-HT1A receptor ligands
... 3 receptor has been isolated by expression cloning in Xenopus oocytes by Maricq et a l7 ^ The cloned receptor exhibits a high sequence homology to other members of the ligand-gated ion channel ...
237
Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer
... chemokine receptor 3 (CXCR3) receptor ligands, monokine induced by g-interferon (CXCL9) and interferon-g- inducible protein-10 (CXCL10) impair tumor growth and metastasis formation through ...
14
Responsive cell–material interfaces
... To mimic the dynamic variation of the display of biomolecules such as cell adhesion receptor ligands in the ECM and modulate more specific cell-material interactions, the presentation of[r] ...
39
ROLE OF VARIOUS OPIOID RECEPTORS IN OPIOID DEPENDENCE AND WITHDRAWAL SYNDROME
... nociceptin receptor 8 . σ (sigma) receptor, although earlier considered an opioid receptor, is no longer considered to be in this family as it is not activated by endogenous ...selective ...
5
The evolving small molecule fluorescent conjugate toolbox for Class A GPCRs
... a receptor-family-based approach, highlighting some of the strengths and weaknesses of the individual molecules and their subsequent ...GPCR ligands remain a developing and dynamic research ...
12
Abstract: As many if not most ligands at G protein-coupled receptor antagonists are inverse
... by all three ligands. The increased GRK2 expression levels in transgenic mice was lowered by treatment with alprenolol or carvedilol, but not with ICI 118,551; in contrast, only carvedilol increased GRK2 ...
33
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
... Reis, E.S., Chen, H., Sfyroera, G., Monk, P.N., Kohl, J., Ricklin, D., Lambris, J.D., 2012. C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel ...
21
Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
... PPARγ ligands that also induced adipogenesis in bone marrow and sec- ondary extramedullary ...PPARγ ligands that dissociate proatherogenic activities from antidiabetic and antiatherogenic activities would ...
10
Expression and prognostic significance of unique ULBPs in pancreatic cancer
... In summary, the expression and effects of NKG2D ligands differ according to the type of tumor cell, due to the heterogeneity of their generation and sensitivity to the microenvironment of the tumor. However, ...
9
Rational Optimization of a Bispecific Ligand Trap Targeting EGF Receptor Family Ligands
... Screening for TGF-α and HB-EGF binding was carried out using the TGF-α and HB-EGF ELISA Kit (R&D System). 96-well plates were coated with 100 μL of anti-human Fc antibody at 1 μg/mL at room temperature overnight. ...
10
MOLECULAR DOCKING STUDIES OF ZANTHOXYLUM TETRASPERMUM WIGHT AND ARN STEM BARK CONSTITUENTS AGAINST 2XNU (ACETYLCHOLINE BINDING PROTEIN)
... neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the motor division of the somatic nervous system. We report the computational molecular docking studies of the different ...
9