RNA methylation
Identification and validation of m6A RNA methylation regulators with clinical prognostic value in Papillary thyroid cancer
... The RNA transcripts of SOX2 were methylated by METTL3 and bonded with IGF2BP2, resulting in regulation of SOX2 ...A RNA methylation and its ...
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<p>Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer</p>
... The RNA sequencing transcriptome data of 13 m6A RNA methyla- tion regulators as well as clinical data were obtained from The Cancer Genome Atlas (TCGA) ESCA ...m6A RNA methylation regulators ...
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Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets
... A RNA methyla- tion in adipose tissue and liver, ...A RNA methylation is commonly considered to be regulated by dietary methyl donors like: methionine, choline and betaine ...A RNA ...
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Multiple functions of m6A RNA methylation in cancer
... Secondly, we need to identify through which mechan- ism m 6 A RNA methylation is introduced. Despite the strong consensus, only a small fraction of RACH sites is detectably methylated in vivo, arguing that ...
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Inhibition of viral RNA methylation in herpes simplex virus type 1-infected cells by 5' S-isobutyl-adenosine.
... Therefore the difference between the percent inhibition of 3H and 35S incorporation into proteins from cells in the presence and absence of SIBA gives a measure of the effect of the drug[r] ...
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Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of clear cell renal carcinoma
... The total RNA of the cell lines and clinical samples was extracted using Trizol reagent (Invitrogen, USA). The cDNA for each cell line and tissue samples were reverse transcribed using the PrimeScript 1st Strand ...
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The interplay between m6A RNA methylation and noncoding RNA in cancer
... MiRNAs belong to a class of small noncoding RNAs and are endogenously encoded short RNAs (∼ 21 nucleo- tides, nt) that are generated from primary transcripts (pri-miRNAs) transcribed by RNA polymerase II/III [67, ...
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RNA Methylation—A Possible Genetic Marker in Cystic Fibrosis
... Fibroblast culture lines were obtained from patients in our cystic fibrosis clinic, and cell lines sent to us from investigators at the Uni- versity of Wisconsin and Cornell University..[r] ...
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RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
... aberrant methylation, which may further disturb RNA metabolism, such as RNA splicing, nuclear export, RNA decay, or ...abnormal RNA methylation is likely one of the reasons ...
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The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation.
... reduced methylation of the d3-4 ...for methylation and suggest that it is the RGG box motif itself which is the target of ...of methylation and to identify the modified ...box methylation play ...
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The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA directed DNA methylation loci
... The RD29A promoter is abiotic stress responsive and is activated when the plant is under cold or salinity. We previously showed that the transcriptional activity of a pRD29A-LUC transgene is regulated by DNA methyla- ...
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Hepatitis Delta Virus Antigen Is Methylated at Arginine Residues, and Methylation Regulates Subcellular Localization and RNA Replication
... circular RNA which encodes a single protein, hepatitis delta antigen ...major methylation site is at arginine-13 (R13), which is in the RGGR motif of an RNA-binding ...The methylation of ...
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24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex
... DNA methylation and RNA expression on a genome- wide scale and in all gene regions, allowing comparison of the circadian properties of DNA methylation sites in the promoter region, 59UTR, exons, ...
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Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events
... stem-loop RNA required for N-7 methylation, we deleted the top and side helices and the two loops ...resulting RNA, ⌬ Hc/Hd/La/Lb, was com- pletely inactive for N-7 methylation ...5. ...
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Fine-Tuning of Histone H3 Lys4 Methylation During Pseudohyphal Differentiation by the CDK Submodule of RNA Polymerase II
... The morphological changes of pseudohyphal yeast are highly correlated with expression of the mannoprotein-encoding FLO gene family (Dranginis et al. 2007). Work focused on under- standing transcriptional regulation of ...
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Detailed insight into the dynamics of the initial phases of de novo RNA-directed DNA methylation in plant cells
... DNA methylation and subsequent tran- scriptional silencing can be a rapid process, initiated practically immediately with the appearance of promoter- specific ...DNA methylation differed depending on the ...
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Arabidopsis RNA Polymerases IV and V Are Required To Establish H3K9 Methylation, but Not Cytosine Methylation, on Geminivirus Chromatin
... when methylation is largely confined to promoter regions ...(B) Methylation of the CP CDS in nonrecovered and recovered ...Cytosine methylation in the CP CDS was assessed in primary (1°) tissue from ...
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Arabidopsis Double-Stranded RNA Binding Protein DRB3 Participates in Methylation-Mediated Defense against Geminiviruses
... that RNA-directed methyl- ation of viral chromatin leading to transcriptional gene silencing (TGS) is a potent antiviral defense which is suppressed by gemi- nivirus- and geminivirus satellite-encoded proteins ...
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Full length autonomous transposable elements are preferentially targeted by expression dependent forms of RNA directed DNA methylation
... dependent methylation in both datasets, and ~25 % failed to replicate (Additional file 4: Figure ...TE methylation resolution between datasets (Additional file 4: Figure S3J) due to our improved TE ...
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Structural Features of the Guide:Target RNA Duplex Required for Archaeal C/D sRNA Guided Nucleotide 2'-O-methylation.
... Guide RNA Structure and Nucleotide 2’-O-Methylation The primary function of the box C/D guide RNAs is to direct the nucleotide- specific 2’-0 ribose methylation of designated nucleotides within a ...
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