Role of Non Coding Genome
Beyond the Exome: The Non-coding Genome and Enhancers in Neurodevelopmental Disorders and Malformations of Cortical Development
... protein- coding exons ...human genome (1–2%), it is likely that patients, in which no disease-causing mutation has been identified, could harbor mutations in genomic regions beyond the ...of ...
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Pathogenicity and selective constraint in the non-coding genome
... scale genome sequencing projects in rare and common disease and high throughput experimental techniques will create tremendous opportunities for better understanding of the non-coding genome ...
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Mutational analysis of non-coding genome in prostate cancer using whole genome sequencing
... major role in the proliferation, survival, and tumorigenicity of pancreatic cancer cells (Furukawa et ...key role in a variety of cellular responses, including proliferation, differentiation, and cell ...
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Missing heritability in Parkinson’s disease: the emerging role of non‑coding genetic variation
... whole genome sequencing (WGS) is now applicable to studies with larger sample ...both coding as well as non-coding ...whole genome, alleviating biases intro- duced by exon-capturing ...
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MYC regulates the non-coding transcriptome
... possible role of MYC in regulating the non-coding RNA transcriptome, triplicate cultures of P493-6 cells were prepared in the presence (low, endogenous MYC) or absence (high MYC) of ...human ...
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Review Article Role of long non-coding RNAs in cancer and associated signal transduction pathways
... human genome contains the blueprint for protein-coding transcripts, which led to the birth of a new category of transcripts- non-coding RNAs ...long non-cod- ing RNAs (lncRNAs) are ...
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The role of long non-coding RNAs in the pathogenesis of hereditary diseases
... of non-coding RNAs and human diseases are available such as Lnc2Cancer, MNDR, ...the role of lncRNAs in the pathogenesis of human ...their role in disease progression was obtained during ...
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The mitochondrial genome of Paragyrodactylus variegatus (Platyhelminthes: Monogenea): differences in major non coding region and gene order compared to Gyrodactylus
... the non-coding region is believed to have a functional ...major non-coding region in ...important role in the initiation of replication and ...
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CncRNAs : RNAs with both coding and non coding roles in development
... the genome, it is plausible that mutations that affect non-coding functions of such cncRNAs could lead to disease ...states. Genome-wide analyses across phyla and throughout developmental ...
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The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
... classic non coding RNAs such as ribosomal (r)RNAs, ribozymes, transfer (t)RNAs and microRNAs ...long non coding RNAs (lncRNAs) are major participants in many fundamental biologic processes ...
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Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA
... In general, transposable elements are transcriptionally inhibited by epigenetic factors, for instance, DNA methylation and histone modification [29]. In a recent study, a group determined that 18 or 22 nt tRFs could ...
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Non coding RNAs and retroviruses
... human genome that do not code proteins (long non-coding RNAs, lncRNAs) ...any coding potential [37]. They appear in the genome in three major forms: anti- sense lncRNAs, intronic ...
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The role of highly conserved non-coding DNA sequences in vertebrate development and evolution
... 128 A direct comparison between the contribution of particular factors to vertebrate and urochordate embryonic development can be made for the Hox family. As described in chapter 5, Hox factors play crucial and conserved ...
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Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non coding regions of the viral genome
... The role of these various compensatory mutations in viral replicative fitness was next assessed on the basis of viral infectiousness in CEMx174 cells. For this purpose, relative p27-CA concentrations in viral ...
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Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome
... large role in controlling expression of an essential gene, then deletion of all copies of that element from the genome could affect cell proliferation or survival [100]; in this case, cells having ...
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Role of a single non coding nucleotide in the evolution of an epidemic African clade of Salmonella
... T he bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium) is one of the best-understood pathogens and a major cause of gastroenteritis globally. One sequence type of S. Typhimurium, ST313, is the ...
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Encoding activities of non-coding RNAs
... in non-coding regions of the genome ...so-called non-coding regions may indeed have a higher level of expression in ...characterized, role in other ...
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Non-Coding RNAs in Bacteria
... fundamental role in the regulatory circuit of the genome under ...the role and functionality of non-coding RNA in the various domains of ...
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Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease
... miRNA associated with a pathologic diagnosis of AD We used a linear regression model controlling for age, sex, study, proportion of neuronal cells, post-mortem interval and a measure of RNA quality (RNA integrity (RIN) ...
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Determining the role of the Xist non-coding RNA in epigenetic programming of X-chromosome inactivation
... Mechanisms to explain how cells identify one X-chromosome among all the chromosomes in the genome to select for silencing are beyond the scope of the current knowledge of epigenetics. In addition, how embryonic ...
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