S-phase checkpoint
A conserved Polϵ binding module in Ctf18 RFC is required for S phase checkpoint activation downstream of Mec1
... the S-phase checkpoint response (2–5), which is activated by an increased exposure of single-strand DNA at replication forks, resulting from the combination of defects in DNA synthesis and the ...
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The Schizosaccharomyces pombe S-Phase Checkpoint Differentiates Between Different Types of DNA Damage
... UV-induced S-phase delay, there remains a small but reproducible difference in the level of FACS signal at the later timepoints in Figure ...or S-phase (Figures 1A, 3A, ...subtle ...
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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
... treating S phase–arrested cells with UCN-01 disrupted the Chk1 response, without any effect on Chk2, and resulted in the initiation of replica- tion at progressively later-replicating sites as well as in an ...
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Regulation of Epstein-Barr Virus Origin of Plasmid Replication (OriP) by the S-Phase Checkpoint Kinase Chk2
... EBV genome stability during latent infection depends on numerous factors, including efficient DNA replication, chro- matin assembly, epigenetic modifications, metaphase chromo- some attachment, and sister-chromatid ...
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“DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint
... intra-S phase checkpoint, was moderately decreased in ΔDBR ...intra-S-phase checkpoint control in the ΔDBR ...intra-S-phase checkpoint activated by ...
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SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
... In summary, we have shown that SIRT1-MT cells incorporate more BrdU than control cells under both normal and replicative stress conditions. Further analysis revealed that this is primarily due to the fact that the ...
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The Saccharomyces cerevisiae F-Box Protein Dia2 Is a Mediator of S-Phase Checkpoint Recovery from DNA Damage
... from checkpoint- activated Rad53, while Mrc1 degradation prevents Rad53 from further ...that checkpoint-ac- tivated Mrc1 is degraded rather than dephosphorylated like Rad53 during checkpoint ...for ...
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The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence
... the S-phase checkpoint is to sufficiently enlarge the nucleotide pool in the cell ...the S-phase checkpoint activation that results in Sml1 deg- radation and free nucleotide pool ...
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DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication
... approach, we used the Chk1 inhibitor UCN-01, which interferes with the replication checkpoint (Feijoo et al., 2001; unpub- lished data). Again, kinetics of replication stress–induced his- tone mRNA decay were ...
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The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε
... During replication stress, non-SMC element 5 NSE5 is required for Smc5/6 protein complex functionality at stalled forks... The RAD6 DNA damage tolerance pathway operates uncoupled from t[r] ...
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Chromatin Remodeling Factors Isw2 and Ino80 Regulate Checkpoint Activity and Chromatin Structure in S Phase
... attenuate checkpoint activity, we would expect deletion of ISW2 and NHP10 to not increase checkpoint activity in the relevant mutant ...given checkpoint protein is not required for Isw2 and Ino80 ...
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Can eukaryotic cells monitor the presence of unreplicated DNA?
... the S phase checkpoint account for the flexibility in the timing of DNA replication? It is not clear whether ongoing DNA replication during an unperturbed S phase triggers the S ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... initiate S-phase checkpoint following IR exposure ...in S- phase ...induces S-phase checkpoint in the cells ...to S-phage checkpoint in response to ...
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Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans
... ABSTRACT The histone demethylase LSD1 was originally discovered by removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1). Several studies suggest that LSD1 plays roles in meiosis as well as ...
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Mcl1p Is a Polymerase α Replication Accessory Factor Important for S-Phase DNA Damage Survival
... the S-phase checkpoint for sur- vival, and they show strong genetic interactions with replica- tion factors important for lagging strand synthesis, such as dna2 helicase and fen1 nuclease (20, 22, ...
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Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials
... 37. Carbone, D.P.; Reck, M.; Paz-Ares, L.; Creelan, B.; Horn, L.; Steins, M.; Felip, E.; van den Heuvel, M.M.; Ciuleanu, T.E.; Badin, F.; Ready, N.; Hiltermann, T.J.N.; Nair, S.; Juergens, R.; Peters, S.; ...
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Eichinger, Christian (2009): Coordination of synaptonemal complex formation and pachytene checkpoint signaling in meiosis. Dissertation, LMU München: Fakultät für Biologie
... pachytene checkpoint and the formation of ...pachytene checkpoint activation and SC ...the checkpoint kinase Mec1 at specific consensus sites is necessary for correct SC maturation (Carballo et ...
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Dnmt1 dependent Chk1 pathway suppression is protective against neuron division
... prevents S phase cell-cycle progression by suppressing E2F transcriptional activity, also regulates epigenetic modifications and is involved in stabilizing the genome to prevent tumor formation (Manning and ...
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Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpoint
... Control points in the cell cycle are also undefined, although the Dictyostelium genome encodes homologues of many proteins implicated in cell cycle regulation in higher eukaryotes (Eichinger et al., 2005). An analysis of ...
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Survival of patients treated with antibiotics and immunotherapy for cancer: A systematic review and meta-analysis
... 14 clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. Ann Oncol 2018, 29, 1437-1444, doi:10.1093/annonc/mdy103. 5. Galli, G.; Triulzi, T.; Proto, ...
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