self-assembling protein nanoparticles
The biodistribution of self-assembling protein nanoparticles shows they are promising vaccine platforms
... in nanoparticles and their various applications ...produce nanoparticles is the use of polypep- tides, which are present in folded or unfolded form, depending on the nature and concentration of a salt in ...
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Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli
... cellular protein release ...virus-like protein nanoparticle (T22-GFP- H6) designed as drug carrier [16] would be affected by the use of this particular fabrication ...a self-organizing, ...
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Engineering self-assembling proteins to produce a safe and effective vaccine for Porcine Reproductive and Respiratory Syndrome
... of nanoparticles to present a dense array of antigenic epitopes to the immune system which can effectively stimulate antibody producing cells (B cells) and T cells, resulting in long-lasting ...multiple ...
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Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
... of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display ...the self-assembly ...
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Novel multi-biotin grafted poly(lactic acid) and its self-assembling nanoparticles capable of binding to streptavidin
... nonspecific protein-resistant and self-assembly properties were maintained due to contained PEGs (Figure 2), which enhanced its feasibility to load medicine via hydrophilic/ hydrophobic interaction and ...
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Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells
... Mitochondria were extracted as described earlier [52]. A 50 μl aliquot was sonicated and used for the measurement of protein content or Western blotting; the remaining part was stored at −80°C until use. To ...
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Self-assembling, protein-based intracellular bacterial organelles: emerging vehicles for encapsulating, targeting and delivering therapeutical cargoes
... of nanoparticles to deliver chemotherapeutics in vivo is now well established, with several formulations and synthesis protocols available ...over, nanoparticles of submicrometer size offers clear ...
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Self-Assembling Peptide Nanomaterials: Molecular Dynamics Studies, Computational Designs And Crystal Structure Characterizations
... protein self-assemblies and derivatives have achieved similar periodic spatial arrangements and have shown great promises in various biomaterial applications for catalysis(47, 198, 199), controlled drug ...
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Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
... than Pgp, we focused our attention on the modulation of the latter. In line with recent findings on lung cancer [33], NZ and - at a lesser extent ZA - lowered the activity of Ras and Ras-downstream effectors ERK1/2 ...
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Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein based, self assembling protein nanoparticle vaccine
... exogenously-derived nanoparticles can be taken up by the local predominant APC, the dendritic cell (DC), and processed for loading onto MHC class I molecules of CD8+ T-lymphocytes via a process known as ...
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Self assembling tensor networks and holography in disordered spin chains
... as expectation values, correlation functions, and entanglement entropy directly and efficiently from the geometry of the TTN. In particular, we find that the distance dependence of the spin-spin correlation function can ...
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Distributed autonomous morphogenesis in a self assembling robotic system
... proposed self-assembly robotic ...the self-assembly process including, for instance, mechanical failure of the docking mechanism or failure of the power or communications busses across the docking ...during ...
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Cyclic peptide poly(HPMA) nanotubes as drug delivery vectors : in vitro assessment, pharmacokinetics and biodistribution
... 21 found to circulate for 10+ hours, and to exhibit significantly lower clearance and higher plasma exposure when compared to the control polymer chains. Such characteristics may enhance passive accumulation in EPR ...
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In situ tissue engineering with synthetic self-assembling peptide nanofiber scaffolds, PuraMatrix, for mucosal regeneration in the rat middle-ear
... synthetic self-assembling peptide nanofiber scaffolds using PuraMatrix, which has been successfully used as scaffolding in tissue engineering, for the repair of damaged ...fluorescent protein (EGFP) ...
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Self-Assembling Characteristics of Cefuroxime Axetile – An Antibiotic Agent
... In order to establish the aggregation behaviour of all amphiphilic drugs in aqueous solution an attempt has been made to investigate micellization tendency of some selected antibiotics. In the first attempt the ...
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Oxide template for self assembling arrays of metal nanoclusters
... based on such nano-objects it is essential to have a large number of identical nano-objects acting in the same manner, i.e. representing a collective behavior [3]. Thus, an array of crystallites regularly arranged and of ...
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Corrosion Protection of Copper by TiO2 Nanoparticles and SN Schiff base Coating
... nanoparticle and immersing time are important parameters on the inhibition efficiency of prepared coating. The electrochemical indicated high ability of coating even at high temperature and immersing time in sodium ...
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Tuning the Hydrophobicity of a Hydrogel by
... pre-gelled solution (b) and incorporating of hydrophobic chains using the self-assemblies (c).. Fluorescent analysis of self-assembling of polymer cross-linkers in a solution 55.[r] ...
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<p>Inhibition of Multiple Myeloma Using 5-Aza-2ʹ-Deoxycytidine and Bortezomib-Loaded Self-Assembling Nanoparticles</p>
... the self-assemble NH2-PEG- PCL nanoparticle system to encapsulate two chemotherapy drugs, DAC and BTZ, for the treatment of multiple mye- ...drug-loaded nanoparticles in inhibiting multiple myeloma cell ...
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Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device
... nanostructured self-assembling peptides and a special combination of growth factors and cytokines to establish a proof of concept to mimic the in vivo hepatocyte microenvironment pattern in vitro for ...
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