Serum growth differentiation factor 15
Serum Growth Differentiation Factor 15 in Patients with Ulcerative Colitis
... in serum GDF-15 was not observed in human volunteers who received erythropoietin or in volunteers who underwent ...with serum GDF-15 levels (Ashby et al. 2010). GDF-15 knock-out mice ...
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The association between serum growth differentiation factor 15 levels and lower extremity atherosclerotic disease is independent of body mass index in type 2 diabetes
... predictive factor for several cardiovascular diseases in patients with atherosclerosis and acute coronary syndrome, and that investigating the levels of GDF15 could improve risk prediction beyond traditional risk ...
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Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood
... biopsies, serum and induced sputum from healthy smokers (n = 23) and COPD subjects (n = 24) observed no correlations between lung and serum biomarkers ...
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<p>Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma</p>
... In this study, we aimed to explore the role of GDFs in GBM. In our preliminary analysis, GDF15 and MSTN were identi fi ed as candidate tumor-promoting genes in GBM. GDF15 has been shown to play a crucial role in the ...
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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo
... sociated with exercise capacity in both patient cohorts. COPD patients show a fi bre shift from a predominance of type I fi bres to a predominance of type IIA fi bres in the quadriceps muscle, and this change in fi bre ...
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Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis
... GDF-15, both tissue-derived and circulating, appeared to be cardio-protective in mouse models for myocardial in- farction and heart failure (Kempf et al., 2006; Xu et al., 2006). Paradoxically, elevated ...
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Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells
... multipotential differentiation of MSC cells used in the study has been verified (Additional file 1: Figure ...bovine serum (FBS) and penicillin-streptomycin (Gibco, Grand Island, NY, USA) at 37 °C in 5 % CO ...
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Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease
... crude serum, we adopted commercial enzyme-linked immunosorbent assay (ELISA) kits purchased from R&D (Quantikine, R&D Systems, USA) (Catalog Number: DY957, DY008) with intra- and inter-assay coefficient of ...
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Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells
... Adipocytes differentiated on coverslips grown alone or co- cultivated with leukemic cells were fixed with 4% parafor- maldehyde and blocked with goat serum. The process was carried out as previously described ...
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A meta-analysis of genome-wide association studies of growth differentiation Factor-15 concentration in blood
... Notably, only three out of the nine SNPs were replicated in an independent cohort (i.e., Sydney MAS) and in the same effect direction as the discovery meta-analysis (rs1054564, rs1227731, rs3195944). A few factors may ...
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Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival
... heparin-binding growth factor originally identified by screening of retinoic acid-responsive genes ...cell growth, survival, and migration, as well as angiogenesis ...bovine serum (FBS) sig- ...
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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest
... proposed. Serum tau may offer better diagnostic accuracy than NSE for poor outcome, although the highest predictive values are likewise observed at 48–72 h from ROSC ...
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Growth Factor-free Chondrogenic Differentiation from Induced
... pluripotent stem cells (hiPSCs) into chondrocytes and cartilage pellet using minicircle vectors.. Minicircles are 5.[r] ...
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The role of TGF superfamily gene expression in the regulation of folliculogenesis and oogenesis in mammals: a review
... TGFA interaction during folliculogenesis (Irving- Rodgers et al. 2006; Tse and Ge 2010). Recently, Akkoyunlu et al. (2003) used the immunoperoxi- dase method to investigate the possible function of these factors during ...
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Original Article Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer
... transforming growth factor-β (TGF-β) superfam- ily ...cell growth and differentiation in embryonic and adult tissues. GDF-15 plays a role in the regulation of cellular responses to ...
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Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro
... cell differentiation, suggesting its important role in favoring this cell ...under serum-free conditions [32–34]; however, recent studies suggest that EGF added to traditional osteogenic medium not only ...
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Determinants of growth differentiation factor 15 in patients with stable and acute coronary artery disease. A prospective observational study
... Continuous data are expressed as proportions and con- tinuous data as mean ± standard error of the mean. Categorical variables were compared by Chi square test, while analysis of variance (ANOVA) for continuous ...
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Neuron Like Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
... Neuronal differentiation of MSC has great potential for cellular ...by growth factors, such as epidermal growth factor (EGF), hepatocyte growth factor (HGF), and vascular ...
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Neuroendocrine Differentiation in the Progression of Prostate Cancer: An Update on Recent Developments
... The origin of NE cells in prostate tumoral lesions and the underlying molecular mechanisms of enrichment remain controversial. As proposed by Bonkhoff et al. [5, 24], NE tumour cells can arise from the intermediate stem ...
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... These results suggested that both of the bio- marker levels in the circulation were associated with staging of the tumor. Serum levels of VEGF and endostatin were significantly decreased after treatment, but will ...
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